{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:31:09Z","timestamp":1791822669455,"version":"4.3.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Dr V\u00e9ronique Brulotte"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Platelet-rich plasma (PRP) is a popular treatment option in managing chronic tendinopathies, although the literature is inconsistent, mainly because of significant heterogeneity in patient populations. Patients who failed conservative management may respond differently than those who have not undergone first-line treatment. This systematic review and meta-analysis aimed to evaluate the efficacy of PRP injections in reducing pain and improving function in patients with chronic tendinopathy who failed conservative treatment. A comprehensive search of Medline, Embase, Cochrane Library, CINAHL Complete and Dissertations &amp; Theses Global was conducted to identify randomized controlled trials (RCTs) comparing the effect of PRP vs non-surgical treatments on pain and functional outcomes in adult non-responders to conservative management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 9 RCTs involving 488 patients were included in the review. Of those, 6 studies at low risk of bias were included in the meta-analysis. PRP significantly reduced pain at both 6 and 12\u2009months compared to control treatments (mean difference: \u22120.83 [95% confidence intervals (CI): \u22121.61 to \u22120.04] at 6\u2009months; and \u22121.11 [95% CI: \u22122.10 to \u22120.12] at 12\u2009months). This effect was also seen at 24\u2009months, although based on limited data. Subgroup analysis revealed no significant differences in pain reduction between upper and lower limb tendinopathies. Functional improvement was observed in some studies, though the heterogeneity in outcome measures precluded a pooled analysis. Heterogeneity was substantial across studies, likely due to differences in PRP preparation, site of tendinopathy, and study methodologies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite these limitations, the findings suggest that PRP reduces pain in patients suffering from chronic tendinopathy who have not responded to first-line therapies. Further high-quality research with standardized protocols and longer follow-up is necessary to confirm PRP\u2019s long-term efficacy and safety.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnaf022","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T18:56:22Z","timestamp":1741805782000},"page":"407-419","source":"Crossref","is-referenced-by-count":14,"title":["Platelet-rich plasma injections as a second-line treatment in patients with tendinopathy-related chronic pain and failure of conservative treatment: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-5495","authenticated-orcid":false,"given":"Mathieu","family":"Nadeau-Vall\u00e9e","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Ellassraoui","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Brulotte","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H3T 1J4,","place":["Canada"]},{"name":"H\u00f4pital Maisonneuve-Rosemont, CIUSSS-de-l\u2019Est-de-l\u2019\u00cele-de-Montr\u00e9al, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC H1T 2M4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"issue":"1","key":"2025070703513657900_pnaf022-B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40634-017-0092-6","article-title":"Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach","volume":"4","author":"Abat","year":"2017","journal-title":"J Exp Orthop"},{"issue":"6","key":"2025070703513657900_pnaf022-B2","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/jor.22806","article-title":"Mechanisms of tendon injury and repair","volume":"33","author":"Thomopoulos","year":"2015","journal-title":"J Orthop Res"},{"issue":"6","key":"2025070703513657900_pnaf022-B3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jor.22869","article-title":"Tendon basic science: development, repair, regeneration, and healing","volume":"33","author":"Andarawis-Puri","year":"2015","journal-title":"J Orthop Res"},{"issue":"4","key":"2025070703513657900_pnaf022-B4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0278-5919(03)00004-8","article-title":"Types and epidemiology of tendinopathy","volume":"22","author":"Maffulli","year":"2003","journal-title":"Clin Sports 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