{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:23:31Z","timestamp":1792106611682,"version":"4.4.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the therapeutic effects of platelet-rich plasma (PRP) injection on pain and mandibular movement in patients with temporomandibular joint disorder (TMJD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Systematic review and meta-analysis of prospective controlled trials. A literature search was conducted in PubMed, Embase, and the Cochrane Library to identify relevant studies published before August 31, 2024.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Not applicable (systematic review and meta-analysis).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Patients diagnosed with temporomandibular joint disorder included in the eligible studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention(s) or Exposure(s)<\/jats:title>\n                  <jats:p>PRP injection compared with arthrocentesis, hyaluronic acid, or corticosteroids.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome(s) and Measure(s)<\/jats:title>\n                  <jats:p>Pain intensity and maximal mandibular opening (MMO) were the primary outcomes. Study quality was assessed using the Cochrane Risk of Bias 2.0 tool for randomized trials and ROBINS-I for nonrandomized studies. Mean difference (MD) or standardized MD with 95% confidence intervals (CIs) was used to evaluate effect size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This meta-analysis included 31 studies involving 1359 patients. Compared to arthrocentesis, PRP significantly reduced pain at 6 months (MD, \u22121.56; 95% CI, \u22122.68 to \u22120.44) and improved mandibular movement at 3 months (MD, 2.16; 95% CI, 0.30 to 4.02) and 6 months (MD, 2.56; 95% CI, 0.76 to 4.35). Compared to hyaluronic acid, PRP significantly reduced pain at 3 months (MD, \u22122.18; 95% CI, \u22123.70 to \u22120.66) and improved mandibular movement at 6 months (MD, 3.67; 95% CI, 1.26 to 6.07). Compared to corticosteroids, PRP reduced pain at 1 month (MD, \u22120.41; 95% CI, \u22120.81 to \u22120.02), 3 months (MD, \u22122.18; 95% CI, \u22123.70 to \u22120.66), and 6 months (MD, \u22121.25; 95% CI, \u22121.52 to \u22120.97), and improved mandibular movement at 6 months (MD, 1.46; 95% CI, 0.27 to 2.64).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions and Relevance<\/jats:title>\n                  <jats:p>PRP injection may be an effective and safe treatment for patients with TMJD. These findings suggest that PRP could serve as a promising minimally invasive option for improving pain and mandibular function in clinical settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnaf042","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:46:13Z","timestamp":1744803973000},"page":"655-672","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of platelet-rich plasma for treating temporomandibular joint disorders: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8836-0795","authenticated-orcid":false,"given":"Jui-Hsu","family":"Tsai","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University , Taipei 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