{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:19:31Z","timestamp":1784823571884,"version":"3.55.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Ricerca Corrente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The aims of this study are to assess the preliminary outcomes of the NOPAIN treatment, which is an acceptance and commitment therapy-based treatment performed in the early postoperative period after total knee arthroplasty (TKA), aimed to prevent the onset of chronic postsurgical pain, as well as to evaluate the predictors of the presence of moderate-to-severe pain after 3 months.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Non-controlled preliminary trial.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Division of Rehabilitation Medicine within an Italian tertiary care hospital.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Eighty patients undergoing postoperative rehabilitation after TKA.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Before the treatment, patients underwent a baseline assessment of pain intensity (Numeric Rating Scale), knee pain, stiffness and function (WOMAC), as well as of potential predictors of the effects of the treatment, namely sex, age, pain duration, catastrophizing (Pain Catastrophizing Scale), psychological distress (Hospital Anxiety and Depression Scale), presence of central sensitization (Central Sensitization Inventory), cognitive flexibility (Wisconsin Card Sorting Test), and heart rate variability. Then, all patients underwent the NOPAIN treatment. Pain intensity, knee pain, stiffness and function, catastrophizing, and psychological distress were also assessed after 3 months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Participation rate was 72% and retention was high, with 81.3% of participants completing all 4 sessions of the NOPAIN treatment. Pain intensity (P &lt; .01), knee pain (P &lt; .01), knee stiffness (P &lt; .01), and knee function (P &lt; .01) improved over time. Female sex and age were associated with lower odds of moderate-to-severe pain at 3 months, whereas presence of central sensitization, baseline pain intensity, rumination, helplessness, and changes in helplessness were associated with higher odds.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study shows that the NOPAIN treatment is feasible, that it can be integrated into standard rehabilitative care, and that it might contribute to the prevention of chronic post-surgical pain. The results of this preliminary study will be the basis for the improvement of the intervention.<\/jats:p>\n <\/jats:sec>\n \n Clinical trials registration<\/jats:title>\n This preliminary trial is part of a broader research project registered in ClinicalTrials.gov (registration number: NCT05769998, link: https:\/\/clinicaltrials.gov\/study\/NCT05769998). Patient enrolment started on June 15, 2021.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/pm\/pnaf145","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:35:03Z","timestamp":1761046503000},"page":"385-392","source":"Crossref","is-referenced-by-count":2,"title":["Acceptance and commitment therapy for prevention of chronic pain after total knee arthroplasty"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-8785","authenticated-orcid":false,"given":"Emanuele Maria","family":"Giusti","sequence":"first","affiliation":[{"name":"EPIMED Research Center, Department of Medicine and Surgery, University of Insubria , Varese 21100,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-9822","authenticated-orcid":false,"given":"Gianluca","family":"Castelnuovo","sequence":"additional","affiliation":[{"name":"Clinical Psychology Research Laboratory, IRCCS Istituto Auxologico Italiano , Verbania 28824,","place":["Italy"]},{"name":"Department of Psychology, Catholic University of the Sacred Heart , Milan 20123,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Manna","sequence":"additional","affiliation":[{"name":"Department of Psychology, Catholic University of the Sacred Heart , Milan 20123,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Varallo","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena 41121,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cattivelli","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Bologna , Bologna 40126,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito Vanni","family":"Petrachi","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, IRCCS Istituto Auxologico Italiano , Milan 20100,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Stramba-Badiale","sequence":"additional","affiliation":[{"name":"Department of Medicine, Neurology and Rehabilitation, IRCCS Istituto Auxologico Italiano , Milan 20100,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-9566","authenticated-orcid":false,"given":"Chiara A M","family":"Spatola","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina , Messina,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"issue":"8","key":"2026040815301577400_pnaf145-B1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1302\/2058-5241.3.180004","article-title":"Chronic pain after total knee arthroplasty","volume":"3","author":"Wylde","year":"2018","journal-title":"EFORT Open Rev"},{"issue":"1","key":"2026040815301577400_pnaf145-B2","doi-asserted-by":"crossref","first-page":"e000435","DOI":"10.1136\/bmjopen-2011-000435","article-title":"What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? 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