{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:31:55Z","timestamp":1793367115477,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of the Assistant Secretary of Defense for Health Affairs","award":["W81XWH-18-1-0800"],"award-info":[{"award-number":["W81XWH-18-1-0800"]}]},{"DOI":"10.13039\/100014055","name":"The U.S. Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]},{"name":"WCG Statistics Collaborative"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Management of refractory chronic low back pain (CLBP) includes a range of treatments (eg, physical therapy, injections, ablations, neurostimulation, surgery) with varying utilization and effectiveness. This pragmatic randomized controlled trial (RCT) evaluated the effectiveness of one treatment option, percutaneous 60-day peripheral nerve stimulation (PNS), compared to usual care with standard interventional management for CLBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred thirty patients with CLBP were randomized in a 1:1 ratio to Group 1 (percutaneous 60-day PNS) or Group 2 (physician-directed usual care with standard interventional management). The Primary Clinical Endpoint evaluated the proportion of participants with \u226550% reductions in CLBP at 3\u2009months post-treatment compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the Primary Endpoint, a greater proportion of participants receiving percutaneous 60-day PNS (55%; n\u2009=\u2009112; 95% confidence interval [CI] = 45-65) experienced \u226550% pain relief compared to usual care with standard interventional management (26%; n\u2009=\u2009110; 95% CI = 17-34; P\u2009&amp;lt;\u2009.001). Concordant with the Primary Endpoint, percutaneous 60-day PNS also produced greater improvements in patient-centric secondary endpoints, including disability, pain interference, health-related quality of life, and analgesic consumption. Reductions in pain and resulting improvements in function were sustained through 6\u2009months with percutaneous 60-day PNS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This prospective multicenter pragmatic RCT met its Primary Clinical Endpoint and found that more participants with CLBP reported pain relief at 3\u2009months after receiving percutaneous 60-day PNS as compared to usual care with standard interventional management. Participants treated with 60-day PNS showed greater reductions in pain and more substantial improvements in functional outcomes through 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov<\/jats:title>\n                    <jats:p>NCT04246281; Primary funding: Department of Defense (DoD), with additional funding needed to complete the study provided by the study\u2019s sponsor, SPR.<\/jats:p>\n                    <jats:p>The protocol is available on ClinicalTrials.gov. The statistical analysis plan and results will be made available within 12 months of the study\u2019s completion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnaf147","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:28:18Z","timestamp":1761222498000},"page":"462-473","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain\u2014a multicenter pragmatic randomized controlled trial (RESET)"],"prefix":"10.1093","volume":"27","author":[{"given":"Zachary L","family":"McCormick","sequence":"first","affiliation":[{"name":"University of Utah School of Medicine Department of Physical Medicine and Rehabilitation, , Salt Lake City, UT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise 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