{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T18:47:24Z","timestamp":1785696444707,"version":"3.56.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postlaminectomy syndrome (PLS) is a chronic pain condition characterized by persistent or recurrent symptoms after lumbar spine surgery. Although chronic pain states have been linked to autonomic dysregulation, inflammation, and increased cardiometabolic burden, the long-term cardiovascular implications of PLS remain unclear. Posterior lumbar fusion (PLF) is one of the most common lumbar procedures, providing a clinically relevant population in which to evaluate whether PLS signals broader cardiovascular vulnerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the TriNetX Global Collaborative Network. Adults aged \u226518\u2009years who underwent PLF between 2015 and 2020 were identified by CPT codes. The exposed cohort included individuals with a new diagnosis of PLS (ICD-10 M96.1) occurring \u22656\u2009months after fusion; matched controls were assigned an index encounter at the corresponding postoperative interval. Outcomes included major cardiac events (MCE), stroke, and MACE (MCE + stroke) within 5\u2009years. Propensity score matching was performed based on demographics, comorbidities, and medication use. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 6384 patients were included in each cohort. PLS was associated with increased 5-year risk of MACE (12.3% vs 10.8%; OR 1.16, 95% CI 1.04-1.29) and MCE (9.9% vs 8.1%; OR 1.26, 95% CI 1.11-1.42). Stroke risk was not significantly different (OR 1.11, 95% CI 0.92-1.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PLS after PLF is associated with elevated long-term cardiac risk. These findings suggest PLS may represent a marker of broader systemic vulnerability, warranting enhanced cardiovascular surveillance and multidisciplinary postoperative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnag028","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:48:51Z","timestamp":1770900531000},"page":"879-882","source":"Crossref","is-referenced-by-count":0,"title":["Association of postlaminectomy syndrome with cardiovascular events in patients undergoing posterior lumbar fusion"],"prefix":"10.1093","volume":"27","author":[{"given":"Yih-Cherng","family":"Wang","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Thing","family":"Khor","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pang-Shuo","family":"Perng","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5335-2291","authenticated-orcid":false,"given":"Hong-Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Chi-Mei Medical Center , Tainan,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0763-8157","authenticated-orcid":false,"given":"Kuan-Yu","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine , Bronx, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-3267","authenticated-orcid":false,"given":"Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"2026080203521668900_pnag028-B1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S1130-1473(07)70253-1","article-title":"Lumbar post-laminectomy syndrome I. 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