{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:07:34Z","timestamp":1791209254752,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioids are a cornerstone of cancer pain management; however, their effects on sensory and pain thresholds in routine clinical settings remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between opioid use and neurometric sensory and pain thresholds in patients with cancer-related pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional observational study assessed quantitative sensory function using the Neurometer. Current perception thresholds (CPT) and pain thresholds (PT) for A\u03b2, A\u03b4, and c fibers were evaluated in 208 adult patients with cancer pain in a hospital-based palliative care setting. Patients were classified according to opioid use, and age-adjusted analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pain thresholds did not differ between the opioid and non-opioid groups in either unadjusted or age-adjusted analyses across all fiber types. After adjustment for age, a significant between-group difference was observed for A\u03b2 CPT, whereas CPT for A\u03b4 and c fibers did not differ between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with cancer-related pain, routine opioid use was not associated with clinically meaningful alterations in pain thresholds in this cohort; however, these findings should be interpreted cautiously given the cross-sectional design and potential residual confounding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnag071","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:47:36Z","timestamp":1781329656000},"page":"1139-1148","source":"Crossref","is-referenced-by-count":0,"title":["Association between opioid use and sensory perception in patients with cancer pain: a neurometric study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-3632","authenticated-orcid":false,"given":"Akifumi","family":"Kanai","sequence":"first","affiliation":[{"name":"Division of Dolorology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine , Sagamihara,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatomo","family":"Ara","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kitasato University School of Medicine , Sagamihara,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kitasato University School of Medicine , Sagamihara,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2026100509371952800_pnag071-B1","author":"World Health Organization","year":"2018"},{"key":"2026100509371952800_pnag071-B2","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1016\/S1470-2045(12)70040-2","article-title":"Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC","volume":"13","author":"Caraceni","year":"2012","journal-title":"Lancet Oncol"},{"key":"2026100509371952800_pnag071-B3","doi-asserted-by":"publisher","first-page":"100146","DOI":"10.1016\/j.ynpai.2023.100146","article-title":"Epigenetic regulation in opioid induced hyperalgesia","volume":"14","author":"Reddy","year":"2023","journal-title":"Neurobiol Pain"},{"key":"2026100509371952800_pnag071-B4","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/S0140-6736(19)30430-1","article-title":"Perioperative opioid analgesia-when is enough too much? 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