{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:24:32Z","timestamp":1786994672209,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DE026728"],"award-info":[{"award-number":["R01 DE026728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the incidence and risk factors of chronic opioid use following head and neck adenoid cystic carcinoma (HNACC) surgery and explore the association between postoperative opioid use and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings<\/jats:title>\n                    <jats:p>Perioperative care of cancer patients at the University of Texas\u2014MD Anderson Cancer Center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>Adults (\u226518\u2009years) who underwent HNACC surgery with curative intent were included; while those with recurrent or metastatic disease at the time of surgery or who received palliative treatment were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multivariable logistics and Cox regression analyses were performed to identify predictors of chronic opioid use and explore associations with recurrence-free survival (RFS) and overall survival (OS). Chronic opioid use was defined as an active opioid prescription documented and reconciled by a clinician on postoperative day 90 (POD90).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 102 subjects included in the study, 47.1% were taking opioids chronically after surgery. Preoperative opioid use was associated with more than double the odds of chronic postoperative opioid use, whereas older age and ASA class 1-2 were associated with reduced odds. Positive surgical margins, bone graft procedures, and neck dissection were independently associated with poorer prognosis. No statistically significant association between opioid use an RFS and OS was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that patients with HNACC exhibit several risk factors for chronic opioid use, underscoring the importance of careful opioid prescribing and monitoring in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnag100","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:51:12Z","timestamp":1785498672000},"source":"Crossref","is-referenced-by-count":0,"title":["Postoperative opioid use and survival outcomes in patients with head and neck adenoid cystic carcinoma. A retrospective study"],"prefix":"10.1093","author":[{"given":"Paloma L","family":"Aveni-Strafile","sequence":"first","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]},{"name":"Anesthesiology and Surgical Oncology Research Group , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas A","family":"Cortes-Mejia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]},{"name":"Anesthesiology and Surgical Oncology Research Group , Houston, TX,","place":["United States"]},{"name":"Department of Pain Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay K","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]},{"name":"Anesthesiology and Surgical Oncology Research Group , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia Scalco","family":"Wachter","sequence":"additional","affiliation":[{"name":"Thoracic\/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-215X","authenticated-orcid":false,"given":"Renata","family":"Ferrarotto","sequence":"additional","affiliation":[{"name":"Thoracic\/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sikora","sequence":"additional","affiliation":[{"name":"Head & Neck Surgery, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Williams","sequence":"additional","affiliation":[{"name":"Pathology, Anatomical, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Leo","family":"Lei","sequence":"additional","affiliation":[{"name":"Head & Neck Surgery, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-1682","authenticated-orcid":false,"given":"Juan P","family":"Cata","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]},{"name":"Anesthesiology and Surgical Oncology Research Group , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081714265007900_pnag100-B1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17101721","article-title":"Global Burden of Rare Cancers: Insights from GLOBOCAN 2022 Estimates","volume":"17","author":"Elmadani","year":"2025","journal-title":"Cancers (Basel)"},{"key":"2026081714265007900_pnag100-B2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.oraloncology.2015.04.005","article-title":"Adenoid cystic carcinoma of the head and neck\u2014An update","volume":"51","author":"Coca-Pelaz","year":"2015","journal-title":"Oral Oncol"},{"key":"2026081714265007900_pnag100-B3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12105-013-0426-3","article-title":"Adenoid cystic carcinoma: Clinical and molecular features","volume":"7","author":"Moskaluk","year":"2013","journal-title":"Head Neck Pathol"},{"key":"2026081714265007900_pnag100-B4","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2174\/0929867327666200304122406","article-title":"Opioid growth factor and its derivatives as potential non-toxic multifunctional anticancer and analgesic compounds. 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