{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:43:42Z","timestamp":1778355822339,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective.\u00a0\u00a0Association between iron deficiency anemia (IDA) and migraine, its subgroups, or tension-type headache (TTH) has not yet been shown. This study aimed to determine whether there was an association between IDA and these disorders.<\/jats:p>\n                  <jats:p>Design.\u00a0\u00a0Case\u2013control study.<\/jats:p>\n                  <jats:p>Setting.\u00a0\u00a0Gebze Fatih General Hospital, Kocaeli, Turkey.<\/jats:p>\n                  <jats:p>Subjects.\u00a0\u00a0Migraine and TTH patients, as well as healthy controls (N\u2009=\u2009170\/group), were investigated.<\/jats:p>\n                  <jats:p>Methods.\u00a0\u00a0Descriptive statistics and multivariate logistic regression analyses were performed. Migraine and TTH groups (that included both sexes) and specific migraine subtypes (females only) were selected as dependent variables with sex, age, family history of migraine, alcohol consumption, cigarette smoking, and IDA selected as independent variables. The migraine subgroups selected were as follows: (1) pure menstrual migraine (PMM) or menstrually related migraine (MRM) and (2) migraine not associated with menses (MNAM).<\/jats:p>\n                  <jats:p>Results.\u00a0\u00a0IDA was more common in patients with migraine than controls (21.7% vs 12.9%, P =\u20090.02). There was no association between IDA and TTH (15.9% vs 12.9%, P\u2009=\u20090.43). Family history of migraine (P &amp;lt;\u20090.001) and IDA (P =\u20090.03) were significant factors in the model of migraine. Age (P\u2009=\u20090.009), family history of migraine (P\u2009&amp;lt;\u20090.001), and IDA (P\u2009=\u20090.018) were significant factors in the model of PMM\/MRM. Only family history of migraine (P &amp;lt;\u20090.001) was significant in the model of MNAM.<\/jats:p>\n                  <jats:p>Conclusions.\u00a0\u00a0Our findings indicate that IDA is significantly associated with PMM\/MRM. Further research may determine whether the complex relationships between estrogen, iron metabolism, and dopamine dysfunction, and their effects on migraine, are underlying reasons for this association.<\/jats:p>","DOI":"10.1093\/pm\/pnv029","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T16:08:28Z","timestamp":1453219708000},"page":"596-605","source":"Crossref","is-referenced-by-count":12,"title":["Iron Deficiency Anemia Is Associated with Menstrual Migraine: A Case\u2013Control Study"],"prefix":"10.1093","volume":"17","author":[{"given":"Selen","family":"G\u00fcr-\u00d6zmen","sequence":"first","affiliation":[{"name":"**Department of Neuroscience, Institute for Experimental and Medical Research (DETAE), Istanbul University, Istanbul, Turkey;"},{"name":"\u2020Department of Neurology, Igdir General Hospital, Igdir, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhan","family":"Karahan-\u00d6zcan","sequence":"additional","affiliation":[{"name":"\u2021Department of Neurology, Gebze Fatih General Hospital, Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,12,12]]},"reference":[{"key":"2025112800265179900_pnv029-B1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The global burden of headache: A documentation of headache prevalence and disability worldwide","volume":"27","author":"Hagen","year":"2007","journal-title":"Cephalalgia"},{"key":"2025112800265179900_pnv029-B2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0895-4356(91)90147-2","article-title":"Epidemiology of headache in a general population\u2013A prevalence study","volume":"44","author":"Rasmussen","year":"1991","journal-title":"J Clin Epidemiol"},{"key":"2025112800265179900_pnv029-B3","first-page":"389","article-title":"Is iron deficiency anemia related to menstrual migraine? 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