{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:32:06Z","timestamp":1781649126358,"version":"3.54.5"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Direction de la Recherche Clinique et de l\u2019innovation of CHU Grenoble Alpes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Although anti-inflammatory drugs are commonly used in acute discogenic sciatica, data regarding their efficacy are scarce and controversial. We compared the efficacy and safety of intravenous ketoprofen and methylprednisolone with placebo in sciatica.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Multicenter, double-blinded randomized controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>Patients with confirmed discogenic acute sciatica, without neurologic deficit, were randomized into three arms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Besides standard-of-care analgesic therapy, they received intravenous injections of methylprednisolone (60\u2009mg\/d) or ketoprofen (200\u2009mg\/d) or placebo for five days. The primary outcome was leg pain over five days. Secondary outcomes were clinical responses at days 3 and 5, lumbar pain, Straight Leg Raise Test and lumbar flexion index, analgesic consumption, realization of lumbar spine injections, and surgery during the study period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-four patients were randomized, and 50 completed the study. In patients admitted to the hospital for pain control with acute lumbar radicular pain due to intervertebral disc herniation and receiving an oral analgesic protocol including paracetamol, nefopam, tramadol, and morphine, there was no additional analgesic effect seen between groups. There was no significant difference in leg pain between the three groups over the study period. In the methylprednisolone group, however, we observed a higher rate of clinically relevant responses at day 3. No difference was observed on other secondary efficacy outcomes and safety.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>No significant difference in leg pain was observed between groups. However, there was a higher proportion of patients relieved with intravenous methylprednisolone at day 3, compared with ketoprofen or placebo.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pny252","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T23:13:11Z","timestamp":1539904391000},"page":"1294-1299","source":"Crossref","is-referenced-by-count":8,"title":["Short-term Efficiency and Tolerance of Ketoprofen and Methylprednisolone in Acute Sciatica: A Randomized Trial"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-1826","authenticated-orcid":false,"given":"Romain","family":"Gastaldi","sequence":"first","affiliation":[{"name":"Rheumatology Department, CHU Grenoble Alpes H\u00f4pital Sud, Echirolles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Durand","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Grenoble Alpes University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Roustit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Inserm UMR 1042, Grenoble, France"},{"name":"Clinical Research Center, CHU Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Zulian","sequence":"additional","affiliation":[{"name":"Regional Hospital of Rheumatology Uriage les Bains, St Martin d'Uriage France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e8ne","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Regional Hospital Annecy, Metz-Tessy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Juvin","sequence":"additional","affiliation":[{"name":"Rheumatology Department, CHU Grenoble Alpes H\u00f4pital Sud, Echirolles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Rheumatology Department, CHU Grenoble Alpes H\u00f4pital Sud, Echirolles, France"},{"name":"GREPI \u2013 Universit\u00e9 Grenoble Alpes, EA7408, St Martin d'H\u00e8res France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athan","family":"Baillet","sequence":"additional","affiliation":[{"name":"Rheumatology Department, CHU Grenoble Alpes H\u00f4pital Sud, Echirolles, France"},{"name":"GREPI \u2013 Universit\u00e9 Grenoble Alpes, EA7408, St Martin d'H\u00e8res France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"issue":"1","key":"2019070801554710400_pny252-B1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.spinee.2013.08.003","article-title":"An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy","volume":"14","author":"Kreiner","year":"2014","journal-title":"Spine J"},{"issue":"22","key":"2019070801554710400_pny252-B2","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/BRS.0b013e318183a4a2","article-title":"Sciatica: Review of epidemiological studies and prevalence estimates","volume":"33","author":"Konstantinou","year":"2008","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"2019070801554710400_pny252-B3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s00586-013-3139-0","article-title":"The prevalence and severity of low back pain and associated symptoms in 3,009 old men","volume":"23","author":"Ghanei","year":"2014","journal-title":"Eur Spine J"},{"key":"2019070801554710400_pny252-B4","first-page":"539","article-title":"Causes and mechanisms of sciatic pains","volume":"42","author":"Cortet","year":"1992","journal-title":"Rev Prat"},{"issue":"16","key":"2019070801554710400_pny252-B5","doi-asserted-by":"crossref","first-page":"1810\u201320.","DOI":"10.1097\/00007632-199508150-00012","article-title":"Spinal nerve root compression","volume":"20","author":"Garfin","year":"1995","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"2019070801554710400_pny252-B6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jbspin.2005.03.003","article-title":"Pathophysiology of disk-related sciatica. 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