{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:25:24Z","timestamp":1784381124531,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of different dosages of pain neuroscience education (PNE) programs on central nociceptive processing in patients with fibromyalgia. Second, to compare the effects of different dosages of PNE programs on numerical pain rating scale (NPRS), disability, and psychological variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single-blind randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Three fibromyalgia centers in Spain (Valencia, Alcorc\u00f3n, Alcal\u00e1 de Henares).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Seventy-seven patients with fibromyalgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were randomized to four groups of PNE: 1) high-dose PNE (N\u2009=\u200920), 2) low\u2013concentrated dose PNE (N\u2009=\u200920), 3) diluted low-dose PNE (N\u2009=\u200920), and (4) control treatment (N\u2009=\u200917), conducted in two 30\u201350-minute sessions in groups of four to six participants. Conditioned pain modulation (CPM), temporal summation (TS), and pressure pain thresholds (PPTs) were assessed at baseline and at three-month follow-up. Secondary outcome measures were the Fibromyalgia Impact Questionnaire, Pain Catastrophizing Scale, and Pain Anxiety Symptoms Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant between-group differences for NPRS in favor of the groups receiving high-dose PNE, with a large effect size at three-month follow-up (P\u2009&amp;lt;\u20090.01, \u03b72p = 0.170), but there were no significant differences between groups for the remaining variables (P\u2009&amp;gt;\u20090.05). All groups improved for central nociceptive processing, psychological variables, disability, and pain intensity (NPRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with fibromyalgia, higher dosages of PNE produced a larger improvement in pain severity at three-month follow-up than other dosages of PNE and biomedical education. However, PNE was not superior to biomedical education in the central nociceptive processing, disability, or psychological variables in patients with fibromyalgia.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnz069","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T12:09:50Z","timestamp":1551528590000},"page":"782-793","source":"Crossref","is-referenced-by-count":51,"title":["How Much Is Needed? Comparison of the Effectiveness of Different Pain Education Dosages in Patients with Fibromyalgia"],"prefix":"10.1093","volume":"21","author":[{"given":"Juan J","family":"Amer-Cuenca","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pecos-Mart\u00edn","sequence":"first","affiliation":[{"name":"Department of Nursing and Physiotheraphy, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mart\u00ednez-Merinero","sequence":"first","affiliation":[{"name":"Department of Nursing and Physiotheraphy, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Lluch Girb\u00e9s","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Universitat de Val\u00e8ncia, Valencia, Spain"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Nijs","sequence":"first","affiliation":[{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Department of Physiotherapy, Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium"},{"name":"Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Meeus","sequence":"first","affiliation":[{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Department Movant, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium"},{"name":"Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Ferrer Pe\u00f1a","sequence":"first","affiliation":[{"name":"Physical Therapy Department and Motion in Brains Research Group, Instituto de Neurociencias y Ciencias del Movimiento (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Aut\uda76\udfada de Madrid, Spain"},{"name":"Centro de Salud Entrev\u00edas. Gerencia de Atenci\u00f1n Primaria. Servicio Madrile\ud875\udfe4e Salud, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"Fern\u00e1ndez-Carnero","sequence":"first","affiliation":[{"name":"Physical Therapy Department and Motion in Brains Research Group, Instituto de Neurociencias y Ciencias del Movimiento (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Aut\uda76\udfada de Madrid, Spain"},{"name":"Department of Physiotherapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, Madrid, Spain"},{"name":"Foundation for Biomedical Research, La Paz University Hospital, IDIPAZ, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"issue":"8","key":"2020040803555739800_pnz069-B1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11916-013-0356-5","article-title":"Worldwide epidemiology of fibromyalgia","volume":"17","author":"Queiroz","year":"2013","journal-title":"Curr Pain Headache Rep"},{"issue":"9","key":"2020040803555739800_pnz069-B2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.4065\/mcp.2011.0206","article-title":"The science of fibromyalgia","volume":"86","author":"Clauw","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"2020040803555739800_pnz069-B3","article-title":"Quality of life related to foot health status in women with fibromyalgia: A case-control study","author":"Palomo-L\u00f3pez","journal-title":"Arch Med Sci"},{"key":"2020040803555739800_pnz069-B4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2147\/JPR.S122255","article-title":"Relationship of depression in participants with nonspecific acute or subacute low back pain and no-pain by age distribution","volume":"10","author":"Calvo-Lobo","year":"2017","journal-title":"J Pain Res"},{"issue":"1","key":"2020040803555739800_pnz069-B5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/s0304-3959(02)00344-5","article-title":"Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome","volume":"102","author":"Staud","year":"2003","journal-title":"Pain"},{"issue":"11","key":"2020040803555739800_pnz069-B6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jpain.2007.06.006","article-title":"Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients","volume":"8","author":"Staud","year":"2007","journal-title":"J Pain"},{"issue":"1\u20132","key":"2020040803555739800_pnz069-B7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/10582450801960339","article-title":"The role of peripheral input for chronic pain syndromes like fibromyalgia syndrome","volume":"16","author":"Staud","year":"2008","journal-title":"J Musculoskeletal Pain"},{"issue":"12","key":"2020040803555739800_pnz069-B8","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1517\/14656566.2014.925446","article-title":"Treatment of central sensitization in patients with \u2018unexplained\u2019 chronic pain: An update","volume":"15","author":"Nijs","year":"2014","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"2020040803555739800_pnz069-B9","doi-asserted-by":"crossref","first-page":"211.","DOI":"10.1186\/ar3306","article-title":"The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"2020040803555739800_pnz069-B10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00002508-199709000-00003","article-title":"Possible deficiencies of pain modulation in fibromyalgia","volume":"13","author":"Lautenbacher","year":"1997","journal-title":"Clin J Pain"},{"issue":"1\u20132","key":"2020040803555739800_pnz069-B11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pain.2004.12.032","article-title":"Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition","volume":"114","author":"Julien","year":"2005","journal-title":"Pain"},{"issue":"1","key":"2020040803555739800_pnz069-B12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3959(96)03295-2","article-title":"Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects","volume":"70","author":"Kosek","year":"1997","journal-title":"Pain"},{"issue":"5","key":"2020040803555739800_pnz069-B13","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/art.10225","article-title":"Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia","volume":"46","author":"Gracely","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"5661","key":"2020040803555739800_pnz069-B14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1093535","article-title":"Empathy for pain involves the affective but not sensory components of pain","volume":"303","author":"Singer","year":"2004","journal-title":"Science"},{"issue":"4","key":"2020040803555739800_pnz069-B15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1526-5900(03)00488-7","article-title":"Unraveling the barriers to reconceptualization of the problem in chronic pain: The actual and perceived ability of patients and health professionals to understand the neurophysiology","volume":"4","author":"Moseley","year":"2003","journal-title":"J Pain"},{"issue":"12","key":"2020040803555739800_pnz069-B16","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.apmr.2011.07.198","article-title":"The effect of neuroscience education on pain, disability, anxiety, and stress in chronic musculoskeletal pain","volume":"92","author":"Louw","year":"2011","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"2020040803555739800_pnz069-B17","first-page":"49","article-title":"Education for patients with fibromyalgia. A systematic review of randomised clinical trials","volume":"62","author":"Elizagaray-Garcia","year":"2016","journal-title":"Rev Neurol"},{"issue":"2","key":"2020040803555739800_pnz069-B18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","article-title":"EULAR revised recommendations for the management of fibromyalgia","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"2020040803555739800_pnz069-B19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/AJP.0b013e31827c7a7d","article-title":"Pain physiology education improves health status and endogenous pain inhibition in fibromyalgia: A double-blind randomized controlled trial","volume":"29","author":"Van Oosterwijck","year":"2013","journal-title":"Clin J Pain"},{"issue":"8","key":"2020040803555739800_pnz069-B20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/papr.12137","article-title":"Written pain neuroscience education in fibromyalgia: A multicenter randomized controlled trial","volume":"14","author":"Van Ittersum","year":"2014","journal-title":"Pain Pract"},{"issue":"3","key":"2020040803555739800_pnz069-B21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/BPO.0000000000000260","article-title":"Does preoperative orientation and education alleviate anxiety in posterior spinal fusion patients? A prospective, randomized study","volume":"35","author":"Rhodes","year":"2015","journal-title":"J Pediatr Orthop"},{"issue":"1","key":"2020040803555739800_pnz069-B22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijsu.2011.10.001","article-title":"CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials","volume":"10","author":"Moher","year":"2012","journal-title":"Int J Surg"},{"issue":"2","key":"2020040803555739800_pnz069-B23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee","volume":"33","author":"Wolfe","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"6","key":"2020040803555739800_pnz069-B24","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3899\/jrheum.100594","article-title":"Fibromyalgia criteria and severity scales for clinical and epidemiological studies: A modification of the ACR preliminary diagnostic criteria for fibromyalgia","volume":"38","author":"Wolfe","year":"2011","journal-title":"J Rheumatol"},{"issue":"9","key":"2020040803555739800_pnz069-B25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/AJP.0b013e31827a784e","article-title":"Combining cognitive-behavioral therapy and milnacipran for fibromyalgia: A feasibility randomized-controlled trial","volume":"29","author":"Ang","year":"2013","journal-title":"Clin J Pain"},{"issue":"5","key":"2020040803555739800_pnz069-B26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.math.2011.04.005","article-title":"How to explain central sensitization to patients with \u2018unexplained\u2019 chronic musculoskeletal pain: Practice guidelines","volume":"16","author":"Nijs","year":"2011","journal-title":"Man Ther"},{"key":"2020040803555739800_pnz069-B27","volume-title":"Explicando el Dolor","author":"Butler","year":"2010"},{"key":"2020040803555739800_pnz069-B28","volume-title":"Explain Pain","author":"Butler","year":"2003"},{"issue":"3","key":"2020040803555739800_pnz069-B29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values","volume":"123","author":"Rolke","year":"2006","journal-title":"Pain"},{"issue":"2","key":"2020040803555739800_pnz069-B30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ptj\/78.2.160","article-title":"Reliability of clinical pressure-pain algometric measurements obtained on consecutive days","volume":"78","author":"Nussbaum","year":"1998","journal-title":"Phys Ther"},{"issue":"9","key":"2020040803555739800_pnz069-B31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2519\/jospt.2011.0106","article-title":"Pressure algometry: What does it really tell us?","volume":"41","author":"Sterling","year":"2011","journal-title":"J Orthop Sports Phys Ther"},{"issue":"6","key":"2020040803555739800_pnz069-B32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1155\/2009\/523098","article-title":"Reliability of temporal summation and diffuse noxious inhibitory control","volume":"14","author":"Cathcart","year":"2009","journal-title":"Pain Res Manag"},{"issue":"1","key":"2020040803555739800_pnz069-B33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/AJP.0000000000000511","article-title":"Preoperative pain neuroscience education combined with knee joint mobilization for knee osteoarthritis: A randomized controlled trial","volume":"34","author":"Lluch","year":"2018","journal-title":"Clin J Pain"},{"issue":"2","key":"2020040803555739800_pnz069-B34","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.36076\/ppj.2013\/16\/E61","article-title":"Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome\/fibromyalgia and rheumatoid arthritis? A double-blind randomized controlled cross-over trial","volume":"16","author":"Meeus","year":"2013","journal-title":"Pain Physician"},{"issue":"5","key":"2020040803555739800_pnz069-B35","first-page":"728","article-title":"The Fibromyalgia Impact Questionnaire: Development and validation","volume":"18","author":"Burckhardt","year":"1991","journal-title":"J Rheumatol"},{"issue":"3","key":"2020040803555739800_pnz069-B36","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/art.33360","article-title":"Development of responder definitions for fibromyalgia clinical trials","volume":"64","author":"Arnold","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"13","key":"2020040803555739800_pnz069-B37","first-page":"487","article-title":"Validation of the Spanish version of the Pain Catastrophizing Scale in fibromyalgia","volume":"131","author":"Garcia","year":"2008","journal-title":"Med Clin (Barc)"},{"issue":"4","key":"2020040803555739800_pnz069-B38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","article-title":"The Pain Catastrophizing Scale: Development and validation","volume":"7","author":"Sullivan","year":"1995","journal-title":"Psychol Assess"},{"issue":"11","key":"2020040803555739800_pnz069-B39","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jpain.2007.06.004","article-title":"An exploration of the psychometric properties of the PASS-20 with a nonclinical sample","volume":"8","author":"Abrams","year":"2007","journal-title":"J Pain"},{"issue":"2","key":"2020040803555739800_pnz069-B40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/B:JOBM.0000019850.51400.a6","article-title":"Psychometric evaluation of the Pain Anxiety Symptoms Scale (PASS) in chronic pain patients","volume":"27","author":"Roelofs","year":"2004","journal-title":"J Behav Med"},{"issue":"1","key":"2020040803555739800_pnz069-B41","article-title":"The Spanish version of the Pain Anxiety Symptoms Scale (PASS-20): Preliminary data on its reliability, validity and factorial structure","volume":"5","author":"L\u00c3\u00b3pez-Mart\u00c3nez","year":"2011","journal-title":"Eur J Pain Suppl"},{"issue":"2","key":"2020040803555739800_pnz069-B42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1179\/108331905X55776","article-title":"Visual analogue scale, numeric pain rating scale and the McGill Pain Questionnaire: An overview of psychometric properties","volume":"10","author":"Kahl","year":"2005","journal-title":"Phys Ther Rev"},{"issue":"5","key":"2020040803555739800_pnz069-B43","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-015587","article-title":"Application of minimal important differences in degenerative knee disease outcomes: A systematic review and case study to inform BMJ rapid recommendations","volume":"7","author":"Devji","year":"2017","journal-title":"BMJ Open"},{"issue":"1","key":"2020040803555739800_pnz069-B44","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-014-0144-x","article-title":"Determining the clinical importance of treatment benefits for interventions for painful orthopedic conditions","volume":"10","author":"Katz","year":"2015","journal-title":"J Orthop Surg Res"},{"key":"2020040803555739800_pnz069-B45","doi-asserted-by":"crossref","DOI":"10.4324\/9780203723524","volume-title":"IBM SPSS Statistics 19 Made Simple","author":"Gray","year":"2012","edition":"1st ed"},{"issue":"2","key":"2020040803555739800_pnz069-B46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpain.2007.09.005","article-title":"Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations","volume":"9","author":"Dworkin","year":"2008","journal-title":"J Pain"},{"issue":"6","key":"2020040803555739800_pnz069-B47","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3899\/jrheum.081090","article-title":"Minimal clinically important difference in the Fibromyalgia Impact Questionnaire","volume":"36","author":"Bennett","year":"2009","journal-title":"J\u00a0Rheumatol"},{"issue":"8","key":"2020040803555739800_pnz069-B48","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.apmr.2010.04.020","article-title":"Pain physiology education improves pain beliefs in patients with chronic fatigue syndrome compared with pacing and self-management education: A double-blind randomized controlled trial","volume":"91","author":"Meeus","year":"2010","journal-title":"Arch Phys Med Rehabil"},{"issue":"5","key":"2020040803555739800_pnz069-B49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00002508-200409000-00007","article-title":"A randomized controlled trial of intensive neurophysiology education in chronic low back pain","volume":"20","author":"Moseley","year":"2004","journal-title":"Clin J Pain"}],"container-title":["Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/painmedicine\/article-pdf\/21\/4\/782\/33015137\/pnz069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/painmedicine\/article-pdf\/21\/4\/782\/33015137\/pnz069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T23:03:25Z","timestamp":1663023805000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/painmedicine\/article\/21\/4\/782\/5479587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,24]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/pm\/pnz069","relation":{},"ISSN":["1526-2375","1526-4637"],"issn-type":[{"value":"1526-2375","type":"print"},{"value":"1526-4637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2019,4,24]]}}}