{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:31:29Z","timestamp":1791502289250,"version":"4.3.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of acupuncture for discogenic sciatica.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Single-center, parallel, randomized controlled sham acupuncture trial.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twelve sessions of acupuncture or sham acupuncture at the same traditional acupoints over four weeks. The primary outcome was change from baseline in weekly mean leg pain, measured by the visual analog scale (VAS) over the four-week treatment period. The secondary outcomes were determined by the change from baseline in mean VAS scores for leg pain, VAS scores for low back pain, Oswestry Disability Index (ODI) scores, and 36-Item Short Form Health Survey (SF-36) scores. Patients were followed for 28\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Forty-six patients were enrolled in this study between June 2017 and January 2018, of which 23 were in the acupuncture group and 23 were in the sham acupuncture group. The between-group difference in weekly mean leg pain measured by the VAS over the four-week treatment period was \u20137.28\u2009mm (95% confidence interval = \u201313.76 to \u20130.80, P\u2009=\u20090.029), which is larger than the minimum clinically important difference of 5\u2009mm. The between-group differences in mean VAS scores for low back pain, ODI scores, and SF-36 scores were not significant in the study period (P\u2009>\u20090.05 for all). The proportion of acupuncture-related adverse events was 4.3%, and all adverse events were mild and transient.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Twelve sessions of acupuncture showed short-term clinical benefits in relieving the symptoms of leg pain for patients with chronic discogenic sciatica compared with sham acupuncture. Acupuncture is safe in treating chronic discogenic sciatica. Further studies with larger sample sizes, a longer treatment period, and long-term follow-up should be conducted to verify these results.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/pm\/pnz167","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T15:13:58Z","timestamp":1560438838000},"page":"2303-2310","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy and Safety of Acupuncture for Chronic Discogenic Sciatica, a Randomized Controlled Sham Acupuncture Trial"],"prefix":"10.1093","volume":"20","author":[{"given":"Ziling","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Acupuncture, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"},{"name":"Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixing","family":"Liu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yao","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"issue":"13","key":"2019110507563529700_pnz167-B1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMra1410151","article-title":"Sciatica","volume":"372","author":"Ropper","year":"2015","journal-title":"New Engl J Med"},{"issue":"6","key":"2019110507563529700_pnz167-B2","article-title":"Relationship between severity of lumbar disc disease and disability scores in sciatica patients","volume":"50","author":"Porchet","year":"2002","journal-title":"Neurosurgery"},{"issue":"2","key":"2019110507563529700_pnz167-B3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0030-5898(20)31644-8","article-title":"The tissue origin of low back pain and sciatica: A report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia","volume":"22","author":"Kuslich","year":"1991","journal-title":"Orthop Clin North Am"},{"issue":"9178","key":"2019110507563529700_pnz167-B4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(99)01312-4","article-title":"Epidemiological features of chronic low-back pain","volume":"354","author":"Andersson","year":"1999","journal-title":"Lancet"},{"issue":"22","key":"2019110507563529700_pnz167-B5","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1056\/NEJMoa064039","article-title":"Surgery versus prolonged conservative treatment for sciatica","volume":"356","author":"Peul","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"2019110507563529700_pnz167-B6","doi-asserted-by":"crossref","first-page":"e002534.","DOI":"10.1136\/bmjopen-2012-002534","article-title":"Surgery versus prolonged conservative treatment for sciatica: 5-year results of a randomised controlled trial","volume":"3","author":"Lequin","year":"2013","journal-title":"BMJ Open"},{"issue":"2","key":"2019110507563529700_pnz167-B7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphys.2017.02.012","article-title":"Low back pain and sciatica in over 16s: Assessment and management NICE Guideline [NG59]","volume":"63","author":"de Campos","year":"2017","journal-title":"J Physiother"},{"issue":"7","key":"2019110507563529700_pnz167-B8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.7326\/M16-2367","article-title":"Noninvasive treatments for acute, subacute, and chronic low back pain: A clinical practice guideline from the American College of Physicians","volume":"166","author":"Qaseem","year":"2017","journal-title":"Ann Intern Med"},{"issue":"10","key":"2019110507563529700_pnz167-B9","doi-asserted-by":"crossref","first-page":"e0204054","DOI":"10.1371\/journal.pone.0204054","article-title":"A comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: An analysis of pain related outcomes and patient help seeking behaviour","volume":"13","author":"Wong","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"2019110507563529700_pnz167-B10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jbspin.2005.03.003","article-title":"Pathophysiology of disk-related sciatica. 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