{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T12:06:57Z","timestamp":1759838817257,"version":"3.37.3"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Mental Health and Drug and Alcohol Office and departmental"},{"name":"Drug and Alcohol Services"},{"name":"National Health and Medical Research Council Research Fellowship","award":["1163961"],"award-info":[{"award-number":["1163961"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study objective was to identify the analgesic efficacy of three different pharmacological strategies in patients receiving methadone or buprenorphine as opioid agonist treatment (OAT). The three pharmacological approaches, a) increasing maintenance methadone\/buprenorphine dose by 30%, b) adding oxycodone, or c) adding a single dose of gabapentin, were compared with a control condition of the participant\u2019s usual OAT dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomized, controlled, double-blinded, double-dummy, within-subject crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Nine participants on stable doses of methadone and eight participants on stable doses of buprenorphine were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An outpatient opioid treatment clinic in inner city Sydney, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cold pressor tolerance test was used to examine experimental pain threshold and tolerance. Ratings of subjective drug effects and safety measures (physiological and cognitive) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in the primary outcome measures of pain thresholds or tolerance between the conditions examined. Interindividual variability was evident. Differences in some subjective measures were identified, including lower pain recall, lower \u201cbad effects,\u201d and higher global satisfaction in the additional methadone condition. In the buprenorphine arm, increased drug liking and \u201cbad effects\u201d were detected with oxycodone administration, while increased subjective intoxication was identified with gabapentin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no evidence of an objective improvement in analgesia with any condition compared with control. Further research is required to optimize pain management strategies in this population.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnz178","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T20:25:39Z","timestamp":1561494339000},"page":"1188-1198","source":"Crossref","is-referenced-by-count":3,"title":["Acute Experimental Pain Responses in Methadone- and Buprenorphine\/Naloxone-Maintained Patients Administered Additional Opioid or Gabapentin: A Double-Blind Crossover Pilot Study"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-3025","authenticated-orcid":false,"given":"Bridin Patricia","family":"Murnion","sequence":"first","affiliation":[{"name":"Drug and Alcohol Services, Central Coast Local Health District, Hamlyn Terrace, Australia"},{"name":"Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Rivas","sequence":"first","affiliation":[{"name":"Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apo","family":"Demirkol","sequence":"first","affiliation":[{"name":"Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Hayes","sequence":"first","affiliation":[{"name":"Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Lintzeris","sequence":"first","affiliation":[{"name":"Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, Australia"},{"name":"National Drug and Alcohol Centre, University of New South Wales, Sydney, Australia"},{"name":"Discipline of Addiction Medicine, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Nielsen","sequence":"first","affiliation":[{"name":"Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, Australia"},{"name":"National Drug and Alcohol Centre, University of New South Wales, Sydney, Australia"},{"name":"Monash Addiction Research Centre, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,24]]},"reference":[{"key":"2020061021344325300_pnz178-B1","volume-title":". 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