{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:24:01Z","timestamp":1768472641028,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100001634","name":"Gateway for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001634","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MSK Translational Research and Integrative Medicine"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007345","name":"Cancer Center","doi-asserted-by":"crossref","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100007345","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate acupuncture as a nonpharmacologic intervention for pain management in patients undergoing hematopoietic stem cell transplantation (HSCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with multiple myeloma undergoing high-dose melphalan chemotherapy and autologous peripheral blood HSCT were randomized to receive either true (TA) or sham acupuncture (SA) once daily for five days starting on the day after chemotherapy. Use of pain medications and pain scores were assessed at baseline and at days 5, 15, and 30 after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 60 evaluable subjects, the SA group (vs TA) had greater than five times odds of increasing pain medication use from baseline. Among patients who were opioid nonusers at baseline, all 15 patients in the TA group remained free from opioid use at the end of the study. In contrast, 20% of those in the SA group (four of the 20 patients) started to use opioids after chemotherapy and stem cell infusion (day 5) and 40% (eight of the 20) had become opioid users by day 30 after HSCT (Fisher exact test P\u2009=\u20090.006). Among patients who were taking opioids at baseline, 14% in the TA group vs 10% in the SA group increased opioid intake at day 5, and 21% (TA) vs 30% (SA) at day 30 (P\u2009=\u20090.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acupuncture appears to significantly reduce the need for pain medications during HSCT and the number of post-HSCT opioid users among baseline opioid nonusers. It warrants further studies as an opioid-sparing intervention for pain in HSCT patients.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnz190","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T11:15:41Z","timestamp":1562757341000},"page":"636-642","source":"Crossref","is-referenced-by-count":17,"title":["Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial"],"prefix":"10.1093","volume":"21","author":[{"given":"Gary","family":"Deng","sequence":"first","affiliation":[{"name":"Integrative Medicine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Giralt","sequence":"first","affiliation":[{"name":"Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Chung","sequence":"first","affiliation":[{"name":"Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Landau","sequence":"first","affiliation":[{"name":"Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Siman","sequence":"first","affiliation":[{"name":"Seattle Cancer Care Alliance, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing S","family":"Li","sequence":"first","affiliation":[{"name":"Integrative Medicine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn","family":"Lapen","sequence":"first","affiliation":[{"name":"Medical School, University of Illinois at Chicago, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun J","family":"Mao","sequence":"first","affiliation":[{"name":"Integrative Medicine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"issue":"5","key":"2020030702332291100_pnz190-B1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1200\/JCO.2011.37.0437","article-title":"Meta-analysis of psychosocial interventions to reduce pain in patients with cancer","volume":"30","author":"Sheinfeld Gorin","year":"2012","journal-title":"J Clin Oncol"},{"issue":"27","key":"2020030702332291100_pnz190-B2","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1200\/JCO.2016.68.5206","article-title":"Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline","volume":"34","author":"Paice","year":"2016","journal-title":"J Clin Oncol"},{"issue":"2","key":"2020030702332291100_pnz190-B3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0304-3959(95)00039-U","article-title":"Relaxation and imagery and cognitive-behavioral training reduce pain during cancer treatment: A controlled clinical trial","volume":"63","author":"Syrjala","year":"1995","journal-title":"Pain"},{"issue":"2","key":"2020030702332291100_pnz190-B4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3959(92)90049-H","article-title":"Hypnosis or cognitive behavioral training for the reduction of pain and nausea during cancer treatment: A controlled clinical trial","volume":"48","author":"Syrjala","year":"1992","journal-title":"Pain"},{"issue":"7","key":"2020030702332291100_pnz190-B5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/AJP.0000000000000021","article-title":"The role of opioid prescription in incident opioid abuse and dependence among individuals with chronic noncancer pain: The role of opioid prescription","volume":"30","author":"Edlund","year":"2014","journal-title":"Clin J Pain"},{"issue":"1","key":"2020030702332291100_pnz190-B6","doi-asserted-by":"crossref","first-page":"15679.","DOI":"10.1038\/s41598-017-16031-y","article-title":"Electroacupuncture attenuates induction of inflammatory pain by regulating opioid and adenosine pathways in mice","volume":"7","author":"Liao","year":"2017","journal-title":"Sci Rep"},{"key":"2020030702332291100_pnz190-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.10.031","article-title":"Adenosine receptor targets for pain","volume":"338","author":"Sawynok","year":"2016","journal-title":"Neuroscience"},{"issue":"4","key":"2020030702332291100_pnz190-B8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000341928","article-title":"Acupuncture-induced pain relief and the human brain's default mode network - 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