{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:27:57Z","timestamp":1792762077438,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>It has been shown that patients with migraine have endothelial dysfunction. Migraine patients with aura, especially, have more clinical manifestations of autonomic nervous system dysfunction. We aimed to evaluate the endothelial and autonomic functions in migraine patients during both migraine headache attack and headache-free periods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This was a cross-sectional, randomized study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects and Methods<\/jats:title>\n                  <jats:p>A total of 130 participants (67 male and 63 female patients, minimum age = 19 years, maximum age = 71 years, mean age = 38.8\u2009\u00b1\u200912.2\u2009years) were enrolled into the study. For the statistical evaluation of data, we classified the participants of the study as follows: group 1: headache (+) aura (+); group 2: headache (+) aura (\u2212); group 3: headache (\u2212) aura (+); group 4: headache (\u2212) aura (\u2212). Noninvasive evaluation of endothelial function was performed by flow-mediated dilation (FMD) and pulse wave analysis methods. Heart rate variability measurements were used for noninvasive evaluation of autonomic functions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Group 1 had a higher FMD ratio than the control group, group 3, or group 4 (P\u2009&amp;lt;\u20090.001, P\u2009&amp;lt;\u20090.001, and P\u2009=\u20090.003, respectively). Group 4 had lower FMD ratio levels than the other migraine groups and or the control group (P\u2009&amp;lt;\u20090.001). Group 3 had the highest high-frequency (HF) power levels among all migraine groups (P\u2009&amp;lt;\u20090.001). Group 2 had higher low-frequency\/HF ratio values than other migraineurs (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We concluded that endothelial dysfunction and headache are closely related. Additionally, higher parasympathetic tonus might be associated with the presence of aura.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnz223","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T07:16:15Z","timestamp":1565162175000},"page":"e222-e231","source":"Crossref","is-referenced-by-count":13,"title":["Endothelial and Autonomic Functions in Patients with Migraine"],"prefix":"10.1093","volume":"21","author":[{"given":"Mehmet Tolga","family":"Dogru","sequence":"first","affiliation":[{"name":"Cardiology Department, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ergin","family":"Dilekoz","sequence":"first","affiliation":[{"name":"Pharmacology Department, Faculty of Medicine, Gazi University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Alpua","sequence":"first","affiliation":[{"name":"Neurology Department, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Eroglu","sequence":"first","affiliation":[{"name":"Neurology Department, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale, Turkey"},{"name":"Emergency Medicine Department, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Kandemir","sequence":"first","affiliation":[{"name":"Cardiology Department, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caglar","family":"Alp","sequence":"first","affiliation":[{"name":"Cardiology Department, Faculty of Medicine, K\u0131r\u0131kkale University, K\u0131r\u0131kkale, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrunnisa","family":"Bolay","sequence":"first","affiliation":[{"name":"Neurology & Algology Department, Faculty of Medicine, Neuropsychiatry Centre, Gazi University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"issue":"9406","key":"2020022910294331400_pnz223-B1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0140-6736(04)15440-8","article-title":"Migraine","volume":"363","author":"Silberstein","year":"2004","journal-title":"Lancet"},{"issue":"5","key":"2020022910294331400_pnz223-B2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nrn1102","article-title":"Neurobiology of migraine","volume":"4","author":"Pietrobon","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2020022910294331400_pnz223-B3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1620\/tjem.211.23","article-title":"Increased nitrosative and oxidative stress in platelets of migraine patients","volume":"211","author":"Yilmaz","year":"2007","journal-title":"Tohoku J Exp Med"},{"issue":"1","key":"2020022910294331400_pnz223-B4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00019501-200602000-00005","article-title":"Decreased endothelium-dependent vasodilation in patients with migraine: A new aspect to vascular pathophysiology of migraine","volume":"17","author":"Yetkin","year":"2006","journal-title":"Coron Artery Dis"},{"key":"2020022910294331400_pnz223-B5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1536\/ihj.14-385","article-title":"Assessment of endothelial function. History, methodological aspects, and clinical perspectives","volume":"56","author":"Higashi","year":"2015","journal-title":"Int Heart J"},{"issue":"1","key":"2020022910294331400_pnz223-B6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijcard.2012.09.047","article-title":"Flow-mediated dilation and cardiovascular risk prediction: A systematic review with meta-analysis","volume":"168","author":"Ras","year":"2013","journal-title":"Int J Cardiol"},{"key":"2020022910294331400_pnz223-B7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2377-10-18","article-title":"Patients with migraine with aura have increased flow mediated dilation","volume":"10","author":"Vernieri","year":"2010","journal-title":"BMC Neurol"},{"issue":"1","key":"2020022910294331400_pnz223-B8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1526-4610.2007.00657.x","article-title":"Increased dilator response to nitrate and decreased flow-mediated dilation in migraineurs","volume":"47","author":"Yetkin","year":"2007","journal-title":"Headache"},{"issue":"6","key":"2020022910294331400_pnz223-B9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1177\/0333102410390396","article-title":"Endothelium-dependent vasodilation in migraine patients","volume":"31","author":"Perko","year":"2011","journal-title":"Cephalalgia"},{"issue":"1","key":"2020022910294331400_pnz223-B10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1526-4610.2006.00532.x","article-title":"Endothelial function in patients with migraine during interictal period","volume":"47","author":"Silva","year":"2007","journal-title":"Headache"},{"issue":"7482","key":"2020022910294331400_pnz223-B11","doi-asserted-by":"crossref","first-page":"63.","DOI":"10.1136\/bmj.38302.504063.8F","article-title":"Risk of ischaemic stroke in people with migraine: Systematic review and meta-analysis of observational studies","volume":"330","author":"Etminan","year":"2005","journal-title":"BMJ"},{"key":"2020022910294331400_pnz223-B12","doi-asserted-by":"crossref","first-page":"b3914.","DOI":"10.1136\/bmj.b3914","article-title":"Migraine and cardiovascular disease: Systematic review and meta-analysis","volume":"339","author":"Schurks","year":"2009","journal-title":"BMJ"},{"issue":"7","key":"2020022910294331400_pnz223-B13","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.amjmed.2009.12.021","article-title":"Migraine headache and ischemic stroke risk: An updated meta-analysis","volume":"123","author":"Spector","year":"2010","journal-title":"Am J Med"},{"key":"2020022910294331400_pnz223-B14","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","volume":"93","year":"1996","journal-title":"Circulation"},{"issue":"23","key":"2020022910294331400_pnz223-B15","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1161\/01.CIR.101.23.e215","article-title":"PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals","volume":"101","author":"Goldberger","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"2020022910294331400_pnz223-B16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0002-9149(88)90917-4","article-title":"Components of heart rate variability measured during healing of acute myocardial infarction","volume":"61","author":"Bigger","year":"1988","journal-title":"Am J Cardiol"},{"issue":"3","key":"2020022910294331400_pnz223-B17","doi-asserted-by":"crossref","first-page":"19.","DOI":"10.1007\/s11916-018-0671-y","article-title":"Migraine and autonomic dysfunction: Which is the horse and which is the jockey?","volume":"22","author":"Miglis","year":"2018","journal-title":"Curr Pain Headache Rep"},{"key":"2020022910294331400_pnz223-B18","first-page":"629","volume-title":"Cephalalgia","year":"2013","edition":"3rd"},{"issue":"6","key":"2020022910294331400_pnz223-B19","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/01.HYP.36.6.952","article-title":"Noninvasive assessment of the digital volume pulse. Comparison with the peripheral pressure pulse","volume":"36","author":"Millasseau","year":"2000","journal-title":"Hypertension"},{"issue":"3","key":"2020022910294331400_pnz223-B20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0735-1097(02)01991-5","article-title":"Assessment of endothelial function using peripheral waveform analysis: A clinical application","volume":"40","author":"Hayward","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2020022910294331400_pnz223-B21","doi-asserted-by":"crossref","first-page":"309\u201317","DOI":"10.1016\/S1474-4422(09)70358-8","article-title":"Migraine aura pathophysiology: The role of blood vessels and microembolisation","volume":"9","author":"Dalkara","year":"2010","journal-title":"Lancet Neurol"},{"issue":"14","key":"2020022910294331400_pnz223-B22","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1177\/0333102416631961","article-title":"Migraine and endothelial function: The HUNT3 Study","volume":"36","author":"Larsen","year":"2016","journal-title":"Cephalalgia"},{"issue":"2","key":"2020022910294331400_pnz223-B23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/14737175.2018.1414601","article-title":"Dysautonomia in the pathogenesis of migraine","volume":"18","author":"Gazerani","year":"2018","journal-title":"Expert Rev Neurother"},{"key":"2020022910294331400_pnz223-B24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuroscience.2016.06.012","article-title":"Neurovascular contributions to migraine: Moving beyond vasodilation","volume":"338","author":"Jacobs","year":"2016","journal-title":"Neuroscience"},{"key":"2020022910294331400_pnz223-B25","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2014\/601515","article-title":"Cerebral endothelial function determined by cerebrovascular reactivity to L-arginine","volume":"2014","author":"Pretnar-Oblak","year":"2014","journal-title":"Biomed Res Int"},{"key":"2020022910294331400_pnz223-B26","first-page":"3","article-title":"Assessment of vascular disease using arterial flow mediated dilation","volume":"58(Suppl)","author":"Patel","year":"2006","journal-title":"Pharmacol Rep"},{"issue":"6","key":"2020022910294331400_pnz223-B27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1526-4610.2011.01929.x","article-title":"Chemical mediators of migraine: Preclinical and clinical observations","volume":"51","author":"Gupta","year":"2011","journal-title":"Headache"},{"issue":"8","key":"2020022910294331400_pnz223-B28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4103\/1735-1995.168384","article-title":"Endothelial dysfunction state in migraine headache and neutrally mediated syncope in children and young adults","volume":"20","author":"Sabri","year":"2015","journal-title":"J Res Med Sci"},{"issue":"17","key":"2020022910294331400_pnz223-B29","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","article-title":"Migraine: Multiple processes, complex pathophysiology","volume":"35","author":"Burstein","year":"2015","journal-title":"J Neurosci"},{"issue":"17","key":"2020022910294331400_pnz223-B30","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.0000000000002059","article-title":"Age-specific association of migraine with cryptogenic TIA and stroke: Population-based study","volume":"85","author":"Li","year":"2015","journal-title":"Neurology"},{"issue":"5","key":"2020022910294331400_pnz223-B31","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s12264-014-1471-y","article-title":"Role of cortical spreading depression in the pathophysiology of migraine","volume":"30","author":"Cui","year":"2014","journal-title":"Neurosci Bull"},{"issue":"5","key":"2020022910294331400_pnz223-B32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00127893-200109000-00002","article-title":"The pathophysiology of migraine","volume":"7","author":"Tepper","year":"2001","journal-title":"Neurologist"}],"container-title":["Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/painmedicine\/article-pdf\/21\/2\/e222\/32739474\/pnz223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/painmedicine\/article-pdf\/21\/2\/e222\/32739474\/pnz223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:30:06Z","timestamp":1582972206000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/painmedicine\/article\/21\/2\/e222\/5585873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,10,11]]},"published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/pm\/pnz223","relation":{},"ISSN":["1526-2375","1526-4637"],"issn-type":[{"value":"1526-2375","type":"print"},{"value":"1526-4637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2019,10,11]]}}}