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Although mental health conditions have been associated with pain interference and child abuse, research has been mixed regarding it acting as a mediator, with even less known among people who inject drugs. Therefore, we sought to explore childhood emotional abuse and pain interference among this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were derived from two prospective cohort studies of community-recruited people who inject drugs in Vancouver, Canada, between June 2014 and November 2016. We employed multivariable generalized estimating equations to examine the relationship between childhood emotional abuse and pain interference in the past six months. We also conducted a mediation analysis to examine whether mental health disorder diagnoses mediated this association.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 822 eligible participants, 341 (41.5%) reported childhood emotional abuse. In a multivariable analysis, experiencing childhood emotional abuse remained independently associated with pain interference (adjusted odds ratio = 1.33, 95% confidence interval [CI] = 1.05\u20131.70) after adjusting for a range of confounders. Results from the mediation analysis yielded a statistically significant positive average causal mediation effect (\u03b2\u2009=\u20090.01, 95% CI = 0.001\u20130.02). Approximately 12% of the effect was due to mediation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results demonstrate among people who inject drugs with chronic pain, those who experienced childhood emotional abuse were more likely to report pain interference, which was partially mediated by mental health disorder diagnosis history. These findings highlight the importance of incorporating screening and appropriate treatment for mental illness into chronic pain treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnz233","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T19:12:57Z","timestamp":1565896377000},"page":"704-713","source":"Crossref","is-referenced-by-count":8,"title":["The Impact of Childhood Emotional Abuse on Pain Interference Among People with Chronic Pain who Inject Drugs in Vancouver, Canada"],"prefix":"10.1093","volume":"21","author":[{"given":"Amy","family":"Prangnell","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"},{"name":"School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Shoveller","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"},{"name":"School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Voon","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"},{"name":"School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hennady","family":"Shulha","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Grant","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M -J","family":"Milloy","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"},{"name":"Department of Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kerr","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"},{"name":"Department of Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanna","family":"Hayashi","sequence":"first","affiliation":[{"name":"British Columbia Centre on Substance Use, Vancouver, BC, Canada"},{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"issue":"1","key":"2020040803562030400_pnz233-B1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/adc.2008.143156","article-title":"Understanding emotional abuse","volume":"95","author":"Rees","year":"2010","journal-title":"Arch Dis Child"},{"issue":"11","key":"2020040803562030400_pnz233-B2","doi-asserted-by":"crossref","first-page":"e1001349.","DOI":"10.1371\/journal.pmed.1001349","article-title":"The long-term health consequences of child physical abuse, emotional abuse, and neglect: A systematic review and meta-analysis","volume":"9","author":"Norman","year":"2012","journal-title":"PLoS Med"},{"issue":"4","key":"2020040803562030400_pnz233-B3","doi-asserted-by":"crossref","first-page":"e68.","DOI":"10.1542\/peds.109.4.e68","article-title":"The psychological maltreatment of children\u2014technical report","volume":"109","author":"Kairys","year":"2002","journal-title":"Pediatrics"},{"issue":"3","key":"2020040803562030400_pnz233-B4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/157340010791792581","article-title":"A review of childhood maltreatment and adolescent substance use relationship","volume":"6","author":"Tonmyr","year":"2010","journal-title":"Curr Psychiatry Rev"},{"issue":"6\u20137","key":"2020040803562030400_pnz233-B5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0145-2134(02)00342-3","article-title":"Emotional abuse and neglect (psychological maltreatment): A conceptual framework","volume":"26","author":"Glaser","year":"2002","journal-title":"Child Abuse Negl"},{"issue":"10","key":"2020040803562030400_pnz233-B6","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/00004583-199910000-00009","article-title":"Child and adolescent abuse and neglect research: A review of the past 10 years. 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