{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:33:01Z","timestamp":1787009581643,"version":"build-2736575974"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the effect of escalating doses of lidocaine infusion with or without added magnesium on pain levels and the duration of pain relief in patients with fibromyalgia (FM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of 74 patients diagnosed with FM who underwent at least three escalating doses of intravenous (IV) lidocaine infusions (5\u2009mg\/kg of body weight, 7.5\u2009mg\/kg, and 7.5\u2009mg\/kg of lidocaine + 2.5\u2009g of magnesium sulfate) was conducted. Each patient\u2019s subjective impression of change in pain intensity and duration of pain relief after each treatment was recorded, along with an 11-point numeric rating scale (NRS) for pain intensity, immediately before and after each infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Short-term lidocaine analgesia was evaluated by the reduction in NRS pain score according to the patients reported pre- (immediately before treatment) and post-treatment (immediately after treatment) values. There was a statistical difference in the NRS score reduction between doses 5\u2009mg\/kg and 7.5\u2009mg\/kg of lidocaine (P = 0.009). Long-term analgesia was evaluated at follow-up visits by the patient\u2019s subjective impression of change in pain intensity and duration of pain relief. There was a statistical difference in the percentage of pain relief and the mean duration of pain relief between the treatments with 5\u2009mg\/kg and 7.5\u2009mg\/kg of lidocaine (P = 0.007 and P = 0.003). Although there was a trend of greater response to magnesium sulfate as a beneficial adjunct to the lidocaine infusion, we were unable to find a statistically significant difference for any of the variables studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that escalating doses of IV lidocaine to 7.5\u2009mg\/kg safely and effectively reduced the pain with prolonged effect in a significant number of patients diagnosed with fibromyalgia. Larger, prospective clinical studies are required to confirm this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pm\/pnz251","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T15:27:04Z","timestamp":1568129224000},"page":"1230-1239","source":"Crossref","is-referenced-by-count":20,"title":["Repeated Intravenous Lidocaine Infusions for Patients with Fibromyalgia: Higher Doses of Lidocaine Have a Stronger and Longer-Lasting Effect on Pain Reduction"],"prefix":"10.1093","volume":"21","author":[{"given":"Igor","family":"Wilderman","sequence":"first","affiliation":[{"name":"Wilderman Medical Clinic, Thornhill, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pugacheva","sequence":"first","affiliation":[{"name":"Wilderman Medical Clinic, Thornhill, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod 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