{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:27:14Z","timestamp":1780554434185,"version":"3.54.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003281","name":"National Insurance Institute of Israel","doi-asserted-by":"publisher","award":["1654191"],"award-info":[{"award-number":["1654191"]}],"id":[{"id":"10.13039\/501100003281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Israel Anti-Drugs Authority","award":["01020036"],"award-info":[{"award-number":["01020036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This comparative cross-sectional study aimed to characterize individuals with substance use disorder (SUD) in self-perception of pain sensitivity, experimental auditory aversiveness, and non-noxious sensory responsiveness, as well as examine the associations with SUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Therapeutic community (TC) individuals with SUD (N\u2009=\u200963, male 88.9%) and healthy controls (N\u2009=\u200960, male 86.7%) completed the Pain Sensitivity Questionnaire (PSQ) and the Sensory Responsiveness Questionnaire\u2013Intensity Scale (SRQ-IS), followed by a psychophysical auditory battery, the Battery of Averseness to Sounds (BAS)\u2013Revised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SUD group scored higher on the PSQ (P\u2009&amp;lt;\u20090.0001), BAS-R aversiveness (P\u2009&amp;lt;\u20090.0001), BAS-R-unpleasantness (P\u2009&amp;lt;\u20090.0001), and on the aftersensation of auditory aversiveness (P\u2009&amp;lt;\u20090.0001) and unpleasantness (P\u2009&amp;lt;\u20090.000). Fifty-four percent of the SUD group vs 11.7% of the control group were identified as having sensory modulation dysfunction (SMD; P\u2009&amp;lt;\u20090.0001). Logistic regression modeling revealed that the SRQ-IS-Aversive score had a stronger relationship, indicating a 12.6-times odds ratio for SUD (P\u2009=\u20090.0002). Finally, a risk score calculated from a linear combination of the logistic regression model parameters is presented based on the PSQ and SRQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to explore sensory and aversive domains using experimental and self-reporting in situ, revealing pain perception alteration that co-occurs with high prevalence of SMD, specifically of the over-responsive type. Findings may be significant in clinical practice for treating pain, and for expanding therapeutic modalities as part of broader rehabilitation in TC and beyond, to better meet personalized therapy.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pm\/pnz292","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T19:31:46Z","timestamp":1570217506000},"page":"1902-1912","source":"Crossref","is-referenced-by-count":11,"title":["Perceived Sensitivity to Pain and Responsiveness to Non-noxious Sensation in Substance Use Disorder"],"prefix":"10.1093","volume":"21","author":[{"given":"Naama","family":"Assayag","sequence":"first","affiliation":[{"name":"Faculty of Medicine, School of Occupational Therapy, Hadassah and Hebrew University, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Bonneh","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, Mina & Everard Goodman Faculty of Life 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