{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:46:13Z","timestamp":1790109973229,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the combination effect of platelet-rich plasma (PRP) and extracorporeal shock wave therapy (ESWT) for moderate carpal tunnel syndrome (CTS), compared with PRP alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A randomized, double-blinded, placebo-controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A single medical center in Taiwan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Patients diagnosed with moderate CTS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>All subjects were administered one dose of ultrasound-guided PRP injection at baseline. After two weeks, one session of rESWT was completed in the intervention group, whereas the control group received one session of sham rESWT. Evaluations were performed at baseline and one, three, and six months post\u2013PRP injection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome Measures<\/jats:title>\n                  <jats:p>The Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) was measured as the primary outcome. Electrophysiological study and cross-sectional area (CSA) of the median nerve were used as secondary outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All 40 enrolled subjects (male\/female: 4\/36) completed the study, resulting in an analysis of 32 wrists per group (total: N\u2009=\u200964 wrists). Compared with the control group, the intervention group did not show statistically significantly superior outcomes, except in BCTQs at one month (mean change \u00b1 SE = \u201311.47\u2009\u00b1\u20091.18 vs \u20137.06\u2009\u00b1\u20091.26, P\u2009=\u20090.013) and distal motor latency at three months (mean change \u00b1 SE = \u20130.59\u2009\u00b1\u20090.09 vs \u20130.30\u2009\u00b1\u20090.09, P\u2009=\u20090.031).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Combined PRP and one-session rESWT was not superior to PRP alone in treating moderate CTS. Further studies with multiple sessions of ESWT and longer follow-up periods are needed to verify the clinical efficacy of ESWT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pm\/pnz309","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T19:13:36Z","timestamp":1571858016000},"page":"1668-1675","source":"Crossref","is-referenced-by-count":13,"title":["The Effectiveness of Platelet-Rich Plasma and Radial Extracorporeal Shock Wave Compared with Platelet-Rich Plasma in the Treatment of Moderate Carpal Tunnel Syndrome"],"prefix":"10.1093","volume":"21","author":[{"given":"Chih-Ya","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"},{"name":"Integrated Pain Management Center, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Yen","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Tsan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"},{"name":"Integrated Pain Management Center, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"issue":"9","key":"2020081623465868600_pnz309-B1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S1388-2457(02)00169-4","article-title":"Carpal tunnel syndrome: Pathophysiology and clinical neurophysiology","volume":"113","author":"Werner","year":"2002","journal-title":"Clin Neurophysiol"},{"key":"2020081623465868600_pnz309-B2","first-page":"CD003219","article-title":"Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome","volume":"1","author":"O'Connor","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"2020081623465868600_pnz309-B3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.apmr.2010.03.022","article-title":"Carpal tunnel syndrome. 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