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Here, we describe a unique class, the commissural GCs, which atypically project to the contralateral hippocampus in mice. Although commissural GCs are rare in the healthy brain, their number and contralateral axon density rapidly increase in a rodent model of temporal lobe epilepsies. In this model, commissural GC axon growth appears together with the well-studied hippocampal mossy fiber sprouting and may be important for the pathomechanisms of epilepsy. Our results augment the current view on hippocampal GC diversity and demonstrate powerful activation of a commissural wiring program in the adult brain.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgad088","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T09:36:52Z","timestamp":1679305012000},"source":"Crossref","is-referenced-by-count":9,"title":["Commissural dentate granule cell projections and their rapid formation in the adult brain"],"prefix":"10.1093","volume":"2","author":[{"given":"Matteo","family":"Egger","sequence":"first","affiliation":[{"name":"Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Z\u00fcrich , Z\u00fcrich 8057 ,","place":["Switzerland"]},{"name":"Adaptive Brain Circuits in Development and Learning (AdaBD), University Research Priority Program (URPP), University of Z\u00fcrich , Z\u00fcrich 8057 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