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Here, we describe a tadpole optic nerve crush (ONC) procedure and assessments of brain reinnervation based on live imaging of RGC-specific transgenes which, when paired with CRISPR\/Cas9 injections at the one-cell stage, can be used to assess the function of regeneration-associated genes in vivo in F0 animals. Using this assay, we find that map3k12, also known as dual leucine zipper kinase (Dlk), is necessary for RGC axonal regeneration and acts in a dose-dependent manner. Loss of Dlk does not affect RGC innervation of the brain during development or visually driven behavior but does block both axonal regeneration and functional vision restoration after ONC. Dlk loss does not alter the acute changes in mitochondrial movement that occur within RGC axons hours after ONC but does completely block the phosphorylation and nuclear translocation of the transcription factor Jun within RGCs days after ONC; yet, Jun is dispensable for reinnervation. These results demonstrate that in a species fully capable of regenerating its RGC axons, Dlk is essential for the axonal injury signal to reach the nucleus but may affect regeneration through a different pathway than by which it signals in mammalian RGCs.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgad109","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T23:55:07Z","timestamp":1680220507000},"source":"Crossref","is-referenced-by-count":4,"title":["Dual leucine zipper kinase is necessary for retinal ganglion cell axonal regeneration in <i>Xenopus laevis<\/i>"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-9319","authenticated-orcid":false,"given":"Lindsay","family":"Fague","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Science, UC Davis Eye Center, University of California, Davis , 1275 Med Science Drive Rm. 3451, Davis, CA 95616 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-6651","authenticated-orcid":false,"given":"Nicholas","family":"Marsh-Armstrong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Science, UC Davis Eye Center, University of California, Davis , 1275 Med Science Drive Rm. 3451, Davis, CA 95616 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"issue":"4","key":"2023072818393685900_pgad109-B1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/archotol.1996.01890160031006","article-title":"Traumatic optic neuropathy. 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