{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:50:50Z","timestamp":1792651850824,"version":"4.5.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (e.g. preeclampsia [PE]) with long-lasting consequences for the mother and offspring. The molecular dialogue between the maternal niche and the developing placenta is critical for the function of this organ. Galectin-1 (gal-1), a highly expressed glycan-binding protein at the maternal\u2013fetal interface, orchestrates the maternal adaptation to pregnancy and placenta development. Down-regulation or deficiency of gal-1 during pregnancy is associated with the development of PE; however, the maternal- and placental-derived gal-1 contributions to the disease onset are largely unknown. We demonstrate that lack of gal-1 imposes a risk for PE development in a niche-specific manner, and this is accompanied by a placental dysfunction highly influenced by the absence of maternal-derived gal-1. Notably, differential placental glycosylation through the Sda-capped N-glycans dominates the invasive trophoblast capacity triggered by maternal-derived gal-1. Our findings show that gal-1 derived from the maternal niche is essential for healthy placenta development and indicate that impairment of the gal-1 signaling pathway within the maternal niche could be a molecular cause for maternal cardiovascular maladaptation during pregnancy.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgad247","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T10:46:43Z","timestamp":1690886803000},"source":"Crossref","is-referenced-by-count":15,"title":["Maternal-derived galectin-1 shapes the placenta niche through Sda terminal glycosylation: Implication for preeclampsia"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-9637","authenticated-orcid":false,"given":"Yiran","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf , 20251 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-9424","authenticated-orcid":false,"given":"Fangqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf , 20251 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Freitag","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf , 20251 Hamburg , Germany"},{"name":"Experimental and Clinical Research Center (ECRC), a cooperation of the Max-Delbr\u00fcck Center for Molecular Medicine (MDC) and Charit\u00e9-Universit\u00e4tsmedizin , 13125 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-8389","authenticated-orcid":false,"given":"Sophia","family":"Borowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf , 20251 Hamburg , Germany"},{"name":"Experimental and Clinical Research Center (ECRC), a cooperation of the Max-Delbr\u00fcck Center for Molecular Medicine (MDC) and Charit\u00e9-Universit\u00e4tsmedizin , 13125 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-8392","authenticated-orcid":false,"given":"Yiru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf , 20251 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-4020","authenticated-orcid":false,"given":"Charlotte","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf , 20251 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh-Choo","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London , London SW7 2AZ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Desforges","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London , London SW7 2AZ , 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