{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:25:05Z","timestamp":1792895105381,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To date, there are no efficacious translational solutions for end-stage urinary bladder dysfunction. Current surgical strategies, including urinary diversion and bladder augmentation enterocystoplasty (BAE), utilize autologous intestinal segments (e.g. ileum) to increase bladder capacity to protect renal function. Considered the standard of care, BAE is fraught with numerous short- and long-term clinical complications. Previous clinical trials employing tissue engineering approaches for bladder tissue regeneration have also been unable to translate bench-top findings into clinical practice. Major obstacles still persist that need to be overcome in order to advance tissue-engineered products into the clinical arena. These include scaffold\/bladder incongruencies, the acquisition and utility of appropriate cells for anatomic and physiologic tissue recapitulation, and the choice of an appropriate animal model for testing. In this study, we demonstrate that the elastomeric, bladder biomechanocompatible poly(1,8-octamethylene-citrate-co-octanol) (PRS; synthetic) scaffold coseeded with autologous bone marrow-derived mesenchymal stem cells and CD34+ hematopoietic stem\/progenitor cells support robust long-term, functional bladder tissue regeneration within the context of a clinically relevant baboon bladder augmentation model simulating bladder trauma. Partially cystectomized baboons were independently augmented with either autologous ileum or stem-cell-seeded small-intestinal submucosa (SIS; a commercially available biological scaffold) or PRS grafts. Stem-cell synergism promoted functional trilayer bladder tissue regeneration, including whole-graft neurovascularization, in both cell-seeded grafts. However, PRS-augmented animals demonstrated fewer clinical complications and more advantageous tissue characterization metrics compared to ileum and SIS-augmented animals. Two-year study data demonstrate that PRS\/stem-cell-seeded grafts drive bladder tissue regeneration and are a suitable alternative to BAE.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgae038","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:10:48Z","timestamp":1706656248000},"source":"Crossref","is-referenced-by-count":11,"title":["Multipotent bone marrow cell\u2013seeded polymeric composites drive long-term, definitive urinary bladder tissue regeneration"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-2162","authenticated-orcid":false,"given":"Matthew I","family":"Bury","sequence":"first","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J","family":"Fuller","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-2851","authenticated-orcid":false,"given":"Xinlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University , Evanston, IL 60208 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Y","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery, University of California at Davis , Davis, CA 95817 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-5637","authenticated-orcid":false,"given":"Renea M","family":"Sturm","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine at UCLA , Los Angeles, CA 90095 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9698-0358","authenticated-orcid":false,"given":"Sang Su","family":"Oh","sequence":"additional","affiliation":[{"name":"Biologic Resources Laboratory, University of Illinois at Chicago , Chicago, IL 60612 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel A","family":"Sofer","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Illinois at Chicago , Chicago, IL 60612 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-1148","authenticated-orcid":false,"given":"Hans C","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany T","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie G","family":"Nolan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0366-1529","authenticated-orcid":false,"given":"Wei","family":"Feng","sequence":"additional","affiliation":[{"name":"Flow Cytometry Core, Research Resources Center, University of Illinois at Chicago , Chicago, IL 60612 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R","family":"Rabizadeh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Barac","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5234-7784","authenticated-orcid":false,"given":"Sonia S","family":"Edassery","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann & Robert H. 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Lurie Children's Hospital of Chicago , Chicago, IL 60611 , USA"},{"name":"Department of Urology, Feinberg School of Medicine, Northwestern University , Chicago, IL 60611 , USA"},{"name":"Simpson Querrey Institute, Northwestern University , Chicago, IL 60611 , USA"},{"name":"Stanley Manne Children's Research Institute, Louis A. Simpson and Kimberly K. 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