{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T21:33:22Z","timestamp":1786397602999,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2307800"],"award-info":[{"award-number":["2023YFC2307800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991491"],"award-info":[{"award-number":["81991491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000649"],"award-info":[{"award-number":["32000649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J02006"],"award-info":[{"award-number":["2021J02006"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Project of Xiamen City","award":["2022CYX0108"],"award-info":[{"award-number":["2022CYX0108"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2019RU022"],"award-info":[{"award-number":["2019RU022"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720220006"],"award-info":[{"award-number":["20720220006"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The XBB.1.5 subvariant has garnered significant attention due to its exceptional immune evasion and transmissibility. Significantly, the evolutionary trajectory of SARS-CoV-2 has shown continual progression, with a recent global shift observed from XBB to BA.2.86, exemplified by the emergence of the predominant JN.1 subvariant. This phenomenon highlights the need for vaccines that can provide broad-spectrum antigenic coverage. In this study, we utilized a NS1-deleted (dNS1) influenza viral vector to engineer an updated live-attenuated vectored vaccine called dNS1-XBB-RBD. This vaccine encodes the receptor-binding domain (RBD) protein of the XBB.1.5 strain. Our findings demonstrate that the dNS1-XBB-RBD vaccine elicits a similar systemic and mucosal immune response compared to its prototypic form, dNS1-RBD. In hamsters, the dNS1-XBB-RBD vaccine provided robust protection against the SARS-CoV-2 immune-evasive strains XBB.1.9.2.1 and Beta. Remarkably, nasal vaccination with dNS1-RBD, which encodes the ancestor RBD gene, also effectively protected hamsters against both the XBB.1.9.2.1 and Beta strains. These results provide valuable insights about nasal influenza-vectored vaccine and present a promising strategy for the development of a broad-spectrum vaccine against COVID-19 in the future.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgae183","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T10:30:43Z","timestamp":1714732243000},"source":"Crossref","is-referenced-by-count":6,"title":["Intranasal influenza-vectored COVID-19 vaccines confer broad protection against SARS-CoV-2 XBB variants in hamsters"],"prefix":"10.1093","volume":"3","author":[{"given":"Junyu","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4100-2217","authenticated-orcid":false,"given":"Congjie","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunzhi","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaode","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningxin","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhong","family":"Ye","sequence":"additional","affiliation":[{"name":"Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. , No.31, Kexueyuan Road, Changping District, Beijing 102206 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-5266","authenticated-orcid":false,"given":"Ningshao","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-634X","authenticated-orcid":false,"given":"Yixin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University , No.4221, Xiang'an South Road, Xiang'an District, Xiamen 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"2024053108512379900_pgae183-B1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/d41586-023-00014-3","article-title":"Coronavirus variant XBB.1.5 rises in the United States\u2014is it a global threat?","volume":"613","author":"Callaway","year":"2023","journal-title":"Nature"},{"key":"2024053108512379900_pgae183-B2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/v16010132","article-title":"Systematic genomic surveillance of SARS-CoV-2 at Xiamen international airport and the port of Xiamen reveals the importance of incoming travelers in lineage 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