{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:32:42Z","timestamp":1787009562006,"version":"build-2736575974"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuropeptide Y (NPY), an endogenous peptide composed of 36 amino acids, has been investigated as a potential therapeutic agent for neurodegenerative diseases due to its neuroprotective attributes. This study investigated the neuroprotective effects of NPY in a mouse model of glaucoma characterized by elevated intraocular pressure (IOP) and progressive retinal ganglion cell degeneration. Elevated IOP in mice was induced through intracameral microbead injections, accompanied by intravitreal administration of NPY peptide. The results demonstrated that NPY treatment preserved both the structural and functional integrity of the inner retina and mitigated axonal damage and degenerative changes in the optic nerve under high IOP conditions. Further, NPY treatment effectively reduced inflammatory glial cell activation, as evidenced by decreased expression of glial fibrillary acidic protein and Iba-1. Notably, endogenous NPY expression and its receptors (NPY-Y1R and NPY-Y4R) levels were negatively affected in the retina under elevated IOP conditions. NPY treatment restored these changes to a significant extent. Molecular analysis revealed that NPY mediates its protective effects through the mitogen-activated protein kinase (MAPK) and PI3K\/Akt signaling pathways. These findings highlight the therapeutic potential of NPY in glaucoma treatment, underscoring its capacity to preserve retinal health, modulate receptor expression under stress, reduce neuroinflammation, and impart protection against axonal impairment.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgae299","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:29:11Z","timestamp":1721971751000},"source":"Crossref","is-referenced-by-count":11,"title":["Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K\/Akt signaling in a glaucoma mouse model"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4649-5913","authenticated-orcid":false,"given":"Viswanthram","family":"Palanivel","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gupta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Chitranshi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-256X","authenticated-orcid":false,"given":"Ole","family":"Tietz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Dementia Research Centre, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-8844","authenticated-orcid":false,"given":"Roshana","family":"Vander Wall","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8584-1550","authenticated-orcid":false,"given":"Reuben","family":"Blades","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Dementia Research Centre, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0158-3079","authenticated-orcid":false,"given":"Kanishka Pushpitha","family":"Maha Thananthirige","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Dementia Research Centre, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Salkar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5093-7657","authenticated-orcid":false,"given":"Chao","family":"Shen","sequence":"additional","affiliation":[{"name":"Microscopy Unit, Faculty of Science and Engineering, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-0764","authenticated-orcid":false,"given":"Veer","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University , Geelong, VIC 3216 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-969X","authenticated-orcid":false,"given":"Stuart L","family":"Graham","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"},{"name":"Save Sight Institute, The University of Sydney , Sydney, NSW 2000 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-0196","authenticated-orcid":false,"given":"Devaraj","family":"Basavarajappa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University , North Ryde, Sydney, NSW 2109 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"2024080715324789000_pgae299-B1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"2024080715324789000_pgae299-B2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jphs.2020.12.009","article-title":"Potential roles of astrocytes and Muller cells in the pathogenesis of glaucoma","volume":"145","author":"Shinozaki","year":"2021","journal-title":"J Pharmacol Sci"},{"key":"2024080715324789000_pgae299-B3","doi-asserted-by":"crossref","first-page":"610788","DOI":"10.3389\/fnins.2021.610788","article-title":"The interaction between microglia and macroglia in glaucoma","volume":"15","author":"Zhao","year":"2021","journal-title":"Front Neurosci"},{"key":"2024080715324789000_pgae299-B4","first-page":"143","article-title":"The role of microglia in the progression of glaucomatous neurodegeneration- a review","volume":"11","author":"Zeng","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"2024080715324789000_pgae299-B5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cne.1104","article-title":"Characterization of neuropeptide Y-expressing cells in the mouse retina using immunohistochemical and transgenic techniques","volume":"432","author":"Sinclair","year":"2001","journal-title":"J Comp Neurol"},{"key":"2024080715324789000_pgae299-B6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0163-7258(95)98598-K","article-title":"Central nervous system pharmacology of neuropeptide Y","volume":"65","author":"Wettstein","year":"1995","journal-title":"Pharmacol Ther"},{"key":"2024080715324789000_pgae299-B7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fendo.2013.00005","article-title":"Neuropeptide Y receptors: how to get subtype selectivity","volume":"4","author":"Pedragosa-Badia","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024080715324789000_pgae299-B8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.expneurol.2012.09.004","article-title":"Neuropeptide Y and its role in CNS disease and repair","volume":"238","author":"Decressac","year":"2012","journal-title":"Exp Neurol"},{"key":"2024080715324789000_pgae299-B9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/5584_2019_427","article-title":"Physiological and therapeutic roles of neuropeptide Y on biological functions","volume":"1237","author":"Shende","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"2024080715324789000_pgae299-B10","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.febslet.2015.05.007","article-title":"Regulation of neuronal communication by G protein-coupled receptors","volume":"589","author":"Huang","year":"2015","journal-title":"FEBS Lett"},{"key":"2024080715324789000_pgae299-B11","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1074\/jbc.M115.678185","article-title":"Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) reduces neurodegeneration and increases neural precursor cell proliferation in a mouse model of Alzheimer disease","volume":"291","author":"Spencer","year":"2016","journal-title":"J Biol Chem"},{"key":"2024080715324789000_pgae299-B12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.expneurol.2010.07.022","article-title":"Neuropeptide Y modifies the disease course in the R6\/2 transgenic model of Huntington's disease","volume":"226","author":"Decressac","year":"2010","journal-title":"Exp Neurol"},{"key":"2024080715324789000_pgae299-B13","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.neurobiolaging.2011.06.018","article-title":"Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease","volume":"33","author":"Decressac","year":"2012","journal-title":"Neurobiol Aging"},{"key":"2024080715324789000_pgae299-B14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.nbd.2016.07.022","article-title":"Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases","volume":"95","author":"Duarte-Neves","year":"2016","journal-title":"Neurobiol Dis"},{"key":"2024080715324789000_pgae299-B15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejcb.2018.04.003","article-title":"Neuropeptide Y mitigates ER stress-induced neuronal cell death by activating the PI3K-XBP1 pathway","volume":"97","author":"Lee","year":"2018","journal-title":"Eur J Cell Biol"},{"key":"2024080715324789000_pgae299-B16","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1111\/j.1471-4159.2008.05334.x","article-title":"Neuropeptide Y stimulates retinal neural cell proliferation\u2013involvement of nitric oxide","volume":"105","author":"Alvaro","year":"2008","journal-title":"J Neurochem"},{"key":"2024080715324789000_pgae299-B17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hipo.20765","article-title":"Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis","volume":"21","author":"Decressac","year":"2011","journal-title":"Hippocampus"},{"key":"2024080715324789000_pgae299-B18","doi-asserted-by":"crossref","first-page":"41921","DOI":"10.1074\/jbc.M110.164020","article-title":"Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia","volume":"285","author":"Ferreira","year":"2010","journal-title":"J Biol Chem"},{"key":"2024080715324789000_pgae299-B19","doi-asserted-by":"crossref","first-page":"e636","DOI":"10.1038\/cddis.2013.160","article-title":"Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate","volume":"4","author":"Santos-Carvalho","year":"2013","journal-title":"Cell Death Dis"},{"key":"2024080715324789000_pgae299-B20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1167\/iovs.12-10776","article-title":"Neuropeptide Y receptors Y1 and Y2 are present in neurons and glial cells in rat retinal cells in culture","volume":"54","author":"Santos-Carvalho","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024080715324789000_pgae299-B21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.preteyeres.2015.03.001","article-title":"Neuropeptide Y system in the retina: from localization to function","volume":"47","author":"Santos-Carvalho","year":"2015","journal-title":"Prog Retin Eye Res"},{"key":"2024080715324789000_pgae299-B22","doi-asserted-by":"crossref","first-page":"1759091415598292","DOI":"10.1177\/1759091415598292","article-title":"Activation of neuropeptide Y receptors modulates retinal ganglion cell physiology and exerts neuroprotective actions in vitro","volume":"7","author":"Martins","year":"2015","journal-title":"ASN Neuro"},{"key":"2024080715324789000_pgae299-B23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pneurobio.2013.10.002","article-title":"Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection","volume":"112","author":"Santos-Carvalho","year":"2014","journal-title":"Prog Neurobiol"},{"key":"2024080715324789000_pgae299-B24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/emmm.201000100","article-title":"Therapeutic potential of neuropeptide Y (NPY) receptor ligands","volume":"2","author":"Brothers","year":"2010","journal-title":"EMBO Mol Med"},{"key":"2024080715324789000_pgae299-B25","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1167\/iovs.12-10581","article-title":"Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma","volume":"54","author":"Frankfort","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024080715324789000_pgae299-B26","doi-asserted-by":"crossref","first-page":"2954721","DOI":"10.1155\/2016\/2954721","article-title":"Retinal macroglial responses in health and disease","volume":"2016","author":"de Hoz","year":"2016","journal-title":"Biomed Res Int"},{"key":"2024080715324789000_pgae299-B27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J Comp Neurol"},{"key":"2024080715324789000_pgae299-B28","doi-asserted-by":"crossref","first-page":"1091697","DOI":"10.3389\/fneur.2023.1091697","article-title":"Alteration of neurofilament heavy chain and its phosphoforms reveals early subcellular damage beyond the optic nerve head in glaucoma","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Neurol"},{"key":"2024080715324789000_pgae299-B29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1167\/iovs.02-0398","article-title":"Increase in dephosphorylation of the heavy neurofilament subunit in the monkey chronic glaucoma model","volume":"44","author":"Kashiwagi","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024080715324789000_pgae299-B30","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/brain\/awaa098","article-title":"Neurofilaments: neurobiological foundations for biomarker applications","volume":"143","author":"Gafson","year":"2020","journal-title":"Brain"},{"key":"2024080715324789000_pgae299-B31","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/35073601","article-title":"Neuropeptide Y functions as a neuroproliferative factor","volume":"410","author":"Hansel","year":"2001","journal-title":"Nature"},{"key":"2024080715324789000_pgae299-B32","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s12640-019-0003-y","article-title":"The role of PI3K\/Akt and ERK in neurodegenerative disorders","volume":"35","author":"Rai","year":"2019","journal-title":"Neurotox Res"},{"key":"2024080715324789000_pgae299-B33","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1111\/bph.15052","article-title":"Low-concentration DMSO accelerates skin wound healing by Akt\/mTOR-mediated cell proliferation and migration in diabetic mice","volume":"177","author":"Guo","year":"2020","journal-title":"Br J Pharmacol"},{"key":"2024080715324789000_pgae299-B34","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2174\/1570159X19666210906120302","article-title":"Neuroprotective effects of neuropeptide y against neurodegenerative disease","volume":"20","author":"Pain","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"2024080715324789000_pgae299-B35","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuint.2007.01.010","article-title":"NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Muller cells","volume":"50","author":"Alvaro","year":"2007","journal-title":"Neurochem Int"},{"key":"2024080715324789000_pgae299-B36","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1074\/jbc.M107224200","article-title":"Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor","volume":"277","author":"Gicquiaux","year":"2002","journal-title":"J Biol Chem"},{"key":"2024080715324789000_pgae299-B37","doi-asserted-by":"crossref","first-page":"025004","DOI":"10.1088\/2050-6120\/3\/2\/025004","article-title":"Internalization mechanism of neuropeptide Y bound to its Y(1) receptor investigated by high resolution microscopy","volume":"3","author":"Kempf","year":"2015","journal-title":"Methods Appl Fluoresc"},{"key":"2024080715324789000_pgae299-B38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0304-3940(95)11973-Z","article-title":"Plasma neuropeptide Y is reduced in patients with Alzheimer's disease","volume":"198","author":"Koide","year":"1995","journal-title":"Neurosci Lett"},{"key":"2024080715324789000_pgae299-B39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0006-8993(90)90082-M","article-title":"Neuropeptide Y receptor binding sites in human brain. Possible alteration in Alzheimer's disease","volume":"519","author":"Martel","year":"1990","journal-title":"Brain Res"},{"key":"2024080715324789000_pgae299-B40","first-page":"327","article-title":"Phenotypic alterations in hippocampal NPY- and PV-expressing interneurons in a presymptomatic transgenic mouse model of Alzheimer's disease","volume":"8","author":"Mahar","year":"2016","journal-title":"Front Aging Neurosci"},{"key":"2024080715324789000_pgae299-B41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.yfrne.2006.07.002","article-title":"Physiology and gene regulation of the brain NPY Y1 receptor","volume":"27","author":"Eva","year":"2006","journal-title":"Front Neuroendocrinol"},{"key":"2024080715324789000_pgae299-B42","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0167-0115(98)00083-4","article-title":"NPY upregulates genes containing cyclic AMP response element in human neuroblastoma cell lines bearing Y1 and Y2 receptors: involvement of CREB","volume":"75\u201376","author":"Sheriff","year":"1998","journal-title":"Regul Pept"},{"key":"2024080715324789000_pgae299-B43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0196-9781(01)00583-6","article-title":"Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]","volume":"23","author":"Sheriff","year":"2002","journal-title":"Peptides"},{"key":"2024080715324789000_pgae299-B44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/geno.1997.4684","article-title":"Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation","volume":"41","author":"Herzog","year":"1997","journal-title":"Genomics"},{"key":"2024080715324789000_pgae299-B45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(08)60823-5","article-title":"Neurofilaments in health and disease","volume":"61","author":"Julien","year":"1998","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"2024080715324789000_pgae299-B46","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00401-011-0807-1","article-title":"The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma","volume":"121","author":"Chidlow","year":"2011","journal-title":"Acta Neuropathol"},{"key":"2024080715324789000_pgae299-B47","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/fcp.12464","article-title":"Inflammatory process in Parkinson disease: neuroprotection by neuropeptide Y","volume":"33","author":"Pain","year":"2019","journal-title":"Fundam Clin Pharmacol"},{"key":"2024080715324789000_pgae299-B48","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1093\/hmg\/ddv271","article-title":"Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease","volume":"24","author":"Duarte-Neves","year":"2015","journal-title":"Hum Mol Genet"},{"key":"2024080715324789000_pgae299-B49","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1742-2094-8-169","article-title":"Neuropeptide Y inhibits interleukin-1beta-induced phagocytosis by microglial cells","volume":"8","author":"Ferreira","year":"2011","journal-title":"J Neuroinflammation"},{"key":"2024080715324789000_pgae299-B50","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.3390\/cells11223665","article-title":"Neuroprotective effects of neuropeptide Y on human neuroblastoma SH-SY5Y cells in glutamate excitotoxicity and ER stress conditions","volume":"11","author":"Palanivel","year":"2022","journal-title":"Cells"},{"key":"2024080715324789000_pgae299-B51","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1073\/pnas.030533197","article-title":"Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors","volume":"97","author":"Pellieux","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024080715324789000_pgae299-B52","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cellsig.2015.03.016","article-title":"Neuropeptide Y receptor mediates activation of ERK1\/2 via transactivation of the IGF receptor","volume":"27","author":"Lecat","year":"2015","journal-title":"Cell Signal"},{"key":"2024080715324789000_pgae299-B53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3892\/ijmm.2016.2833","article-title":"PI3K\/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review)","volume":"39","author":"Nakano","year":"2017","journal-title":"Int J Mol Med"},{"key":"2024080715324789000_pgae299-B54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s43556-021-00036-1","article-title":"G-protein coupled receptor, PI3K and rho signaling pathways regulate the cascades of Tau and amyloid-beta in Alzheimer's disease","volume":"2","author":"Desale","year":"2021","journal-title":"Mol Biomed"},{"key":"2024080715324789000_pgae299-B55","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/aos.13806","article-title":"Neuropeptide Y treatment induces retinal vasoconstriction and causes functional and histological retinal damage in a porcine ischaemia model","volume":"96","author":"Christiansen","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"2024080715324789000_pgae299-B56","doi-asserted-by":"crossref","first-page":"840","DOI":"10.4103\/1673-5374.344952","article-title":"Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma","volume":"18","author":"Basavarajappa","year":"2023","journal-title":"Neural Regen Res"},{"key":"2024080715324789000_pgae299-B57","doi-asserted-by":"crossref","first-page":"e22710","DOI":"10.1096\/fj.202201346R","article-title":"S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun\/Bim cascade and Bad phosphorylation in a mouse model of glaucoma","volume":"37","author":"Basavarajappa","year":"2023","journal-title":"FASEB J"},{"key":"2024080715324789000_pgae299-B58","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.ymthe.2023.03.008","article-title":"Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma","volume":"31","author":"Chitranshi","year":"2023","journal-title":"Mol Ther"},{"key":"2024080715324789000_pgae299-B59","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.7150\/thno.55472","article-title":"Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner","volume":"11","author":"Abbasi","year":"2021","journal-title":"Theranostics"},{"key":"2024080715324789000_pgae299-B60","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.bbadis.2014.05.026","article-title":"BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma","volume":"1842","author":"Gupta","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2024080715324789000_pgae299-B61","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2022.01.020","article-title":"Trkb receptor agonist 7,8 dihydroxyflavone is protective against the inner retinal deficits induced by experimental glaucoma","volume":"490","author":"Gupta","year":"2022","journal-title":"Neuroscience"},{"key":"2024080715324789000_pgae299-B62","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.mito.2013.08.005","article-title":"Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection","volume":"13","author":"Rajala","year":"2013","journal-title":"Mitochondrion"},{"key":"2024080715324789000_pgae299-B63","doi-asserted-by":"crossref","first-page":"25127","DOI":"10.1021\/acsami.8b07560","article-title":"Peptide nanofiber substrates for long-term culturing of primary neurons","volume":"10","author":"Martin","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"2024080715324789000_pgae299-B64","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1128\/MCB.05659-11","article-title":"Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14","volume":"31","author":"Basavarajappa","year":"2011","journal-title":"Mol Cell Biol"},{"key":"2024080715324789000_pgae299-B65","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.biochi.2008.01.004","article-title":"Alpha-1-proteinase inhibitor is a heparin binding serpin: molecular interactions with the Lys rich cluster of helix-F domain","volume":"90","author":"Gupta","year":"2008","journal-title":"Biochimie"},{"key":"2024080715324789000_pgae299-B66","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ymthe.2018.09.019","article-title":"Loss of Shp2 rescues BDNF\/TrkB signaling and contributes to improved retinal ganglion cell neuroprotection","volume":"27","author":"Chitranshi","year":"2019","journal-title":"Mol Ther"}],"container-title":["PNAS Nexus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pnasnexus\/advance-article-pdf\/doi\/10.1093\/pnasnexus\/pgae299\/58655352\/pgae299.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pnasnexus\/article-pdf\/3\/8\/pgae299\/58758601\/pgae299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pnasnexus\/article-pdf\/3\/8\/pgae299\/58758601\/pgae299.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:55:21Z","timestamp":1723060521000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pnasnexus\/article\/doi\/10.1093\/pnasnexus\/pgae299\/7721204"}},"subtitle":[],"editor":[{"given":"Andrey","family":"Abramov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,5]]}},"URL":"https:\/\/doi.org\/10.1093\/pnasnexus\/pgae299","relation":{},"ISSN":["2752-6542"],"issn-type":[{"value":"2752-6542","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,7,26]]},"article-number":"pgae299"}}