{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:07:59Z","timestamp":1787501279593,"version":"build-2736575974"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Doctoral Training Partnership","award":["MR\/K50127X\/1"],"award-info":[{"award-number":["MR\/K50127X\/1"]}]},{"name":"Sir Henry Wellcome Postdoctoral Fellowship","award":["224190\/Z\/21\/Z"],"award-info":[{"award-number":["224190\/Z\/21\/Z"]}]},{"name":"Centre for Global Infectious Disease Analysis","award":["MR\/X020258\/1"],"award-info":[{"award-number":["MR\/X020258\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The relative contributions of exposure vs. acquired immunity to the epidemiology of human schistosomiasis has been long debated. While there is considerable evidence that humans acquire partial immunity to infection, age- and sex-related contact patterns with water bodies contaminated with infectious cercarial schistosome larvae also contribute to typical epidemiological profiles of infection. Here, we develop a novel schistosome transmission model that incorporates both partially protective \u201cdelayed concomitant\u201d acquired immunity\u2014stimulated by dying worms\u2014and host age- and sex-dependent patterns of exposure. We use a contemporary Bayesian approach to fit the model to historical individual data on exposure to infectious cercaria, eggs per gram of feces, and immunoglobulin E antibodies specific to Schistosoma mansoni Tegumental-Allergen-Like protein 1 collected from a highly endemic community in Uganda, estimating the relative contributions of exposure and acquired immunity. We find that model variants incorporating or omitting delayed concomitant immunity describe equally well the age- and sex-specific immunoepidemiological patterns observed before intervention and 18 months after treatment. Over longer time horizons, we find that acquired immunity creates subtle differences in immunoepidemiological profiles during routine mass drug administration that may confer resilience against elimination. We discuss our findings in the broader context of the immunoepidemiology of schistosomiasis.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgae471","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:52:05Z","timestamp":1729155125000},"source":"Crossref","is-referenced-by-count":6,"title":["Revisiting immunity vs. exposure in schistosomiasis: A mathematical modeling study of delayed concomitant immunity"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-3321","authenticated-orcid":false,"given":"Gregory C","family":"Milne","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Population Sciences, Royal Veterinary College , Hatfield, AL9 7TA ,","place":["United Kingdom"]},{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C","family":"Oettle","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge , Cambridge, CB2 1QP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5003-2575","authenticated-orcid":false,"given":"Charles","family":"Whittaker","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United Kingdom"]},{"name":"MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcis B","family":"Kabatereine","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ugandan Ministry of Health , PO Box 1661, Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-3361","authenticated-orcid":false,"given":"Maria-Gloria","family":"Bas\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United Kingdom"]},{"name":"MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8616-4919","authenticated-orcid":false,"given":"Joanne P","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences, Royal Veterinary College , Hatfield, AL9 7TA ,","place":["United Kingdom"]},{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-5365","authenticated-orcid":false,"given":"Martin","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences, Royal Veterinary College , Hatfield, AL9 7TA ,","place":["United Kingdom"]},{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London , London, W12 0BZ ,","place":["United 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