{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:18:41Z","timestamp":1793737121439,"version":"4.6.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China Joint Fund Project","award":["U23A2034"],"award-info":[{"award-number":["U23A2034"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Zhejiang Province Leading Geese Plan","award":["2024C03110"],"award-info":[{"award-number":["2024C03110"]}]},{"name":"Oceanic Interdisciplinary Program of Shanghai Jiao Tong University","award":["SL2022PT205"],"award-info":[{"award-number":["SL2022PT205"]}],"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Shanghai Frontiers Science Center of Polar Science"},{"name":"Icelandic Research Fund","award":["207298-052"],"award-info":[{"award-number":["207298-052"]}]},{"DOI":"10.13039\/100006180","name":"Technology Development Fund","doi-asserted-by":"publisher","award":["163922-0613"],"award-info":[{"award-number":["163922-0613"]}],"id":[{"id":"10.13039\/100006180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Circadian clocks exist in all types of organisms and coordinate key biological processes, e.g. photosynthesis in phytoplankton (microalgae) and land plants. We asked whether a circadian rhythm sustains in phytoplankton when living under constant illumination without environmental cues. Here, we report the first transcriptomic architecture of persistent oscillatory gene expression in the model marine diatom, Phaeodactylum tricornutum living under constant illumination and temperature without environmental cues. We show that cyclic expression of a considerable number of genes involved in light harvesting and carbon fixation sustained after 24\u2005h of constant illumination (free-running), which could pose additional constraints on cell growth under constant light conditions. Over long-term adaptation to constant illumination, the majority of the rhythmic genes identified under diel light conditions lose their oscillatory expression in the absence of external entrainers, and the genes potentially controlled by persistent circadian clocks are primarily involved in transcriptional regulation and cell division. We find constant illumination leads to an increased average expression of transcription factors and cell division genes, while genes involved in the Calvin\u2013Benson cycle and pigment biosynthesis are kept at low expression levels, which plays a role in the down-regulation of photosynthetic efficiency. By manipulation of the dark rest period, we confirm a fine-tuned light\/dark cycle could dramatically improve photosynthetic efficiency in microalgae. Our results unveil a novel persistent circadian rhythm on photosynthetic regulation in marine phytoplankton and provide critical insights into the interaction between environmental signals and inheritable internal circadian clocks in diatoms.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgae497","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:48:50Z","timestamp":1730872130000},"source":"Crossref","is-referenced-by-count":18,"title":["An undiscovered circadian clock to regulate phytoplankton photosynthesis"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-6010","authenticated-orcid":false,"given":"Yixi","family":"Su","sequence":"first","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]},{"name":"Ocean Research Center of Zhoushan, Zhejiang University , Zhoushan 316021 ,","place":["China"]},{"name":"Center for Systems Biology and Faculty of Industrial Engineering, School of Engineering and Natural Sciences, University of Iceland , Reykjav\u00edk 101 ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsheng","family":"Xia","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-4793","authenticated-orcid":false,"given":"Jiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhao","family":"Meng","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qian","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexuan","family":"Shu","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-0267","authenticated-orcid":false,"given":"Xianwei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Oceanography, Shanghai Jiao Tong University , Shanghai 200030 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6521-5243","authenticated-orcid":false,"given":"Kourosh","family":"Salehi-Ashtiani","sequence":"additional","affiliation":[{"name":"Laboratory of Algal, Systems, and Synthetic Biology, Division of Science and Math & Center for Genomics and Systems Biology, New York University Abu Dhabi , Abu Dhabi 129188 ,","place":["UAE"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9435-2258","authenticated-orcid":false,"given":"Sigur\u00f0ur","family":"Brynj\u00f3lfsson","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Faculty of Industrial Engineering, School of Engineering and Natural Sciences, University of Iceland , Reykjav\u00edk 101 ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-3711","authenticated-orcid":false,"given":"Jianping","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University , Hangzhou 310058, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongquan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biotechnology & Research Center for Clinical Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou 310058, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]},{"name":"Ocean Academy, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University , Zhoushan 316021, Zhejiang ,","place":["China"]},{"name":"Key Laboratory of Offshore Geotechnics and Material of Zhejiang Province, College of Civil Engineering and Architecture, Zhejiang University , Hangzhou 310058, Zhejiang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-383X","authenticated-orcid":false,"given":"Weiqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang 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