{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:26:41Z","timestamp":1792063601884,"version":"4.4.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"DYNAMO","award":["ANR-11-LABX-0011-01"],"award-info":[{"award-number":["ANR-11-LABX-0011-01"]}]},{"name":"CACSICE","award":["ANR-11-EQPX-0008"],"award-info":[{"award-number":["ANR-11-EQPX-0008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The driving mechanisms at the base of the clearance of biological wastes in the brain interstitial space (ISS) are still poorly understood and an actively debated subject. A complete comprehension of the processes that lead to the aggregation of amyloid proteins in such environment, hallmark of the onset and progression of Alzheimer\u2019s disease, is of crucial relevance. Here we employ combined computational fluid dynamics and molecular dynamics techniques to uncover the role of fluid flow and proteins transport in the brain ISS. Our work identifies diffusion as the principal mechanism for amyloid-\u03b2 proteins clearance, whereas fluid advection may lead transport for larger molecular bodies, like amyloid-\u03b2 aggregates or extracellular vesicles. We also clearly quantify the impact of large nascent prefibrils on the fluid flowing and shearing. Finally, we show that, even in the irregular brain interstitial space (ISS), hydrodynamic interactions enhance amyloid-\u03b2 aggregation at all stages of the aggregation pathway. Our results are key to understand the role of fluid flow and solvent-solute interplay on therapeutics like antibodies acting in the brain ISS.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgae548","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:13:19Z","timestamp":1733872399000},"source":"Crossref","is-referenced-by-count":6,"title":["Fluid flow and amyloid transport and aggregation in the brain interstitial space"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-3038","authenticated-orcid":false,"given":"Antonio","family":"Iorio","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Laboratoire de Biochimie \u00a0 Th\u00e9orique, 13 rue Pierre et Marie Curie, Paris 75005 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