{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:32:08Z","timestamp":1792481528963,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG066626"],"award-info":[{"award-number":["R01AG066626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is defined by cognitive decline in conjunction with accumulation of aggregated amyloid \u03b2 (A\u03b2) and tau, yet existing models of AD fail to provide a simple connection between A\u03b2 and tau. However, microtubules provide an intriguing nexus for pathological interactions between the two. Tau binds to microtubules and is critical to maintaining their proper function. We demonstrate that A\u03b2 also binds to microtubules with affinity comparable to that of tau itself. We hypothesize that displacement of tau by A\u03b2 leads to microtubule dysfunction and facilitates tau phosphorylation and aggregation. Importantly, in this model, aggregation of A\u03b2 is not the primary cause of toxicity, which allows many of the apparent contradictions between A\u03b2 pathology and cognition to be rationalized. This model highlights the importance of both tau and A\u03b2 and enables additional therapeutic and intervention strategies to be considered.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgag034","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:01:51Z","timestamp":1773748911000},"source":"Crossref","is-referenced-by-count":2,"title":["The microtubule nexus linking amyloid beta and tau: A simple and unifying theory for the underlying cause of Alzheimer's disease"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0839-6272","authenticated-orcid":false,"given":"Thomas A","family":"Shoff","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of California , Riverside, CA 92521 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