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Intersectional genetic lineage tracing and EdU labeling, combined with transcriptomic analyses, revealed that YAP-activated MGs predominantly regenerate MGs, whereas only a subset gives rise to bipolar cell-like neurons. These results indicate that proliferative MGs acquire a state resembling that of late-stage retinal progenitors, with limited neurogenic lineage potential. We conclude that YAP-activated cell-cycle reentry inefficiently reprograms adult MGs toward photoreceptor or ganglion cell fates. These findings define the limited competence of proliferative adult MGs to contribute to neurogenic fates and provide a rigorous framework for assessing in vivo glial reprogramming strategies.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgag188","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:24:58Z","timestamp":1780025098000},"source":"Crossref","is-referenced-by-count":0,"title":["Transient YAP activation uncovers the neurogenic potential of proliferative mammalian M\u00fcller glia"],"prefix":"10.1093","volume":"5","author":[{"given":"English J","family":"Laserna","sequence":"first","affiliation":[{"name":"Genetics and Genomics Graduate Program, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina V","family":"Saltykova","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin S","family":"Dhindsa","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Graduate Program, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Human and Molecular Genetics, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-8835","authenticated-orcid":false,"given":"Borna","family":"Sarker","sequence":"additional","affiliation":[{"name":"Department of Human and Molecular Genetics, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrea E","family":"Hurley","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G","family":"Swinton","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"The Texas Heart Institute, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Lagor","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Graduate Program, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-3499","authenticated-orcid":false,"given":"Nicholas M","family":"Tran","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Graduate Program, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Human and Molecular Genetics, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-9857","authenticated-orcid":false,"given":"James F","family":"Martin","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Graduate Program, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"The Texas Heart Institute, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Center for Organ Repair and Renewal, Baylor College of Medicine , Houston, TX 77003 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-2383","authenticated-orcid":false,"given":"Ross A","family":"Poch\u00e9","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Graduate Program, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Integrative Physiology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Center for Organ Repair and Renewal, Baylor 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Population-level integration of single-cell datasets enables multi-scale analysis across samples. 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