{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:07:37Z","timestamp":1784300857684,"version":"3.55.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["F31EY035931"],"award-info":[{"award-number":["F31EY035931"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY033037"],"award-info":[{"award-number":["R01EY033037"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY035324"],"award-info":[{"award-number":["R01EY035324"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T32EY007026"],"award-info":[{"award-number":["T32EY007026"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY002520"],"award-info":[{"award-number":["P30EY002520"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY00331"],"award-info":[{"award-number":["P30EY00331"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["T32GM008042l"],"award-info":[{"award-number":["T32GM008042l"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM008042l"],"award-info":[{"award-number":["T32GM008042l"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McPherson Eye Research Institute's Rebecca Meyer Brown\/Retina Research Foundation Professorship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Retinal circuit assembly relies on the precise timing and positioning of key molecules between neuronal partners to mediate proper synapse formation. In the outer retina, horizontal cells (HCs) are important interneurons that make the first contacts with photoreceptors and begin to segregate visual information into two distinct pathways by selectively forming synapses to the different types of photoreceptors. Dendrites of HCs synapse exclusively to cone photoreceptors, whereas the axon terminal synapses to rod photoreceptors. Failure to properly form these early connections disrupts the downstream connectivity of other postsynaptic neurons and leads to abnormal visual function. Although these early events are critical for proper synapse development, little is known about how this process is coordinated in the outer retina. In the present study, we performed single-cell RNA sequencing and uncovered members of the cytoskeletal scaffolding family of ankyrins to be differentially expressed in HCs during development. Specifically, we found ankyrin-B to be highly expressed in HCs at early time points and ankyrin-G to be expressed at later stages. Genetic deletion of both ankyrin-B and ankyrin-G disrupts outer retinal synaptic integrity and leads to impaired in vivo retinal responses. In summary, our findings uncovered a new requirement for ankyrin-B and ankyrin-G in maintaining synaptic connectivity in the outer retina essential for normal visual function.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgag239","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:15:57Z","timestamp":1783581357000},"source":"Crossref","is-referenced-by-count":0,"title":["Ankyrin-B and ankyrin-G are required for synaptic integrity in the mouse outer retina"],"prefix":"10.1093","volume":"5","author":[{"given":"Ross M","family":"Perez","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-2055","authenticated-orcid":false,"given":"Jay","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison , Madison, WI 53705 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-1012","authenticated-orcid":false,"given":"Martina","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Stein Eye Institute, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Todora","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Becerril","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-6875","authenticated-orcid":false,"given":"Debalina","family":"Goswami-Sewell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajashree","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesiah C","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7307-6598","authenticated-orcid":false,"given":"Caitlin","family":"Bagnetto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon F","family":"Mattos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-2779","authenticated-orcid":false,"given":"Yi-Rong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Stein Eye Institute, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-8743","authenticated-orcid":false,"given":"Mrinalini","family":"Hoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison , Madison, WI 53705 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-1062","authenticated-orcid":false,"given":"Elizabeth","family":"Zuniga-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]},{"name":"Department of Neuroscience, Baylor College of Medicine , Houston, TX 77030 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"2026071710470224400_pgag239-B1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ydbio.2021.04.001","article-title":"Development and maintenance of vision's first synapse","volume":"476","author":"Burger","year":"2021","journal-title":"Dev Biol"},{"key":"2026071710470224400_pgag239-B2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nn.2236","article-title":"Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions","volume":"12","author":"Huckfeldt","year":"2009","journal-title":"Nat Neurosci"},{"key":"2026071710470224400_pgag239-B3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuron.2018.03.004","article-title":"Role for Wnt signaling in retinal neuropil development: analysis via RNA-Seq and in vivo somatic CRISPR mutagenesis","volume":"98","author":"Sarin","year":"2018","journal-title":"Neuron"},{"key":"2026071710470224400_pgag239-B4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuron.2020.07.019","article-title":"Brainwide genetic sparse cell labeling to illuminate the morphology of neurons and glia with cre-dependent MORF mice","volume":"108","author":"Veldman","year":"2020","journal-title":"Neuron"},{"key":"2026071710470224400_pgag239-B5","first-page":"250","article-title":"An electron microscopic study of synapse formation, receptor outer segment development, and other aspects of developing mouse retina","volume":"7","author":"Olney","year":"1968","journal-title":"Invest Ophthalmol"},{"key":"2026071710470224400_pgag239-B6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cne.901560107","article-title":"Synaptogenesis in the photoreceptor terminal of the mouse retina","volume":"156","author":"Blanks","year":"1974","journal-title":"J Comp Neurol"},{"key":"2026071710470224400_pgag239-B7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/(SICI)1096-9861(19971110)388:1<47::AID-CNE4>3.0.CO;2-O","article-title":"Migration and synaptogenesis of cone photoreceptors in the developing mouse retina","volume":"388","author":"Rich","year":"1997","journal-title":"J Comp Neurol"},{"key":"2026071710470224400_pgag239-B8","doi-asserted-by":"crossref","first-page":"14099","DOI":"10.1523\/JNEUROSCI.4046-07.2007","article-title":"Lim1 is essential for the correct laminar positioning of retinal horizontal cells","volume":"27","author":"Poche","year":"2007","journal-title":"J Neurosci"},{"key":"2026071710470224400_pgag239-B9","doi-asserted-by":"crossref","first-page":"17847","DOI":"10.1523\/JNEUROSCI.1373-13.2013","article-title":"Development and plasticity of outer retinal circuitry following genetic removal of horizontal cells","volume":"33","author":"Keeley","year":"2013","journal-title":"J Neurosci"},{"key":"2026071710470224400_pgag239-B10","doi-asserted-by":"crossref","first-page":"657594","DOI":"10.3389\/fncel.2021.657594","article-title":"Synaptic remodeling in the cone pathway after early postnatal horizontal cell ablation","volume":"15","author":"Nemitz","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"2026071710470224400_pgag239-B11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cell.2020.04.008","article-title":"Synaptic specificity, recognition molecules, and assembly of neural circuits","volume":"181","author":"Sanes","year":"2020","journal-title":"Cell"},{"key":"2026071710470224400_pgag239-B12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-neuro-072116-031607","article-title":"Establishing wiring specificity in visual system circuits: from the retina to the brain","volume":"40","author":"Zhang","year":"2017","journal-title":"Annu Rev Neurosci"},{"key":"2026071710470224400_pgag239-B13","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.neuron.2015.09.002","article-title":"Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision","volume":"87","author":"Cao","year":"2015","journal-title":"Neuron"},{"key":"2026071710470224400_pgag239-B14","doi-asserted-by":"crossref","first-page":"23914","DOI":"10.1073\/pnas.2009940117","article-title":"Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors","volume":"117","author":"Cao","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026071710470224400_pgag239-B15","doi-asserted-by":"crossref","first-page":"11949","DOI":"10.1523\/JNEUROSCI.1521-13.2013","article-title":"NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina","volume":"33","author":"Soto","year":"2013","journal-title":"J Neurosci"},{"key":"2026071710470224400_pgag239-B16","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1523\/JNEUROSCI.0063-23.2023","article-title":"betaII-spectrin is required for synaptic positioning during retinal development","volume":"43","author":"Goswami-Sewell","year":"2023","journal-title":"J Neurosci"},{"key":"2026071710470224400_pgag239-B17","doi-asserted-by":"crossref","first-page":"635849","DOI":"10.3389\/fncir.2021.635849","article-title":"Neurofascin is a novel component of rod photoreceptor synapses in the outer retina","volume":"15","author":"Pourhoseini","year":"2021","journal-title":"Front Neural Circuits"},{"key":"2026071710470224400_pgag239-B18","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.cub.2016.06.016","article-title":"Glutamatergic monopolar interneurons provide a novel pathway of excitation in the mouse retina","volume":"26","author":"Della Santina","year":"2016","journal-title":"Curr Biol"},{"key":"2026071710470224400_pgag239-B19","doi-asserted-by":"crossref","first-page":"e94908","DOI":"10.7554\/eLife.94908","article-title":"A non-conducting role of the Ca(v)1.4 Ca(2+) channel drives homeostatic plasticity at the cone photoreceptor synapse","volume":"13","author":"Maddox","year":"2024","journal-title":"Elife"},{"key":"2026071710470224400_pgag239-B20","doi-asserted-by":"crossref","first-page":"e62184","DOI":"10.7554\/eLife.62184","article-title":"A dual role for Ca(v)1.4 Ca(2+) channels in the molecular and structural organization of the rod photoreceptor synapse","volume":"9","author":"Maddox","year":"2020","journal-title":"Elife"},{"key":"2026071710470224400_pgag239-B21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.visres.2014.06.005","article-title":"Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses","volume":"103","author":"Tse","year":"2014","journal-title":"Vision Res"},{"key":"2026071710470224400_pgag239-B22","doi-asserted-by":"crossref","first-page":"ENEURO.0148-15.2016","DOI":"10.1523\/ENEURO.0148-15.2016","article-title":"Targeted deletion of vesicular GABA transporter from retinal horizontal cells eliminates feedback modulation of photoreceptor calcium channels","volume":"3","author":"Hirano","year":"2016","journal-title":"eNeuro"},{"key":"2026071710470224400_pgag239-B23","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat Commun"},{"key":"2026071710470224400_pgag239-B24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cm.21602","article-title":"Cargo hold and delivery: Ankyrins, spectrins, and their functional patterning of neurons","volume":"77","author":"Lorenzo","year":"2020","journal-title":"Cytoskeleton (Hoboken)"},{"key":"2026071710470224400_pgag239-B25","first-page":"1854","article-title":"Localization of the paranodal protein Caspr in the mammalian retina","volume":"16","author":"O'Brien","year":"2010","journal-title":"Mol Vis"},{"key":"2026071710470224400_pgag239-B26","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/nn.3858","article-title":"Glial ankyrins facilitate paranodal axoglial junction assembly","volume":"17","author":"Chang","year":"2014","journal-title":"Nat Neurosci"},{"key":"2026071710470224400_pgag239-B27","doi-asserted-by":"crossref","first-page":"14018","DOI":"10.1074\/jbc.M113.454439","article-title":"E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin","volume":"288","author":"Jenkins","year":"2013","journal-title":"J Biol Chem"},{"key":"2026071710470224400_pgag239-B28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ydbio.2004.03.039","article-title":"Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter","volume":"271","author":"Rowan","year":"2004","journal-title":"Dev Biol"},{"key":"2026071710470224400_pgag239-B29","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1083\/jcb.147.5.995","article-title":"Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins","volume":"147","author":"Tuvia","year":"1999","journal-title":"J Cell Biol"},{"key":"2026071710470224400_pgag239-B30","doi-asserted-by":"crossref","first-page":"583391","DOI":"10.3389\/fncir.2020.583391","article-title":"C1q regulates horizontal cell neurite confinement in the outer retina","volume":"14","author":"Burger","year":"2020","journal-title":"Front Neural Circuits"},{"key":"2026071710470224400_pgag239-B31","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/cne.23452","article-title":"Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1","volume":"522","author":"Ribic","year":"2014","journal-title":"J Comp Neurol"},{"key":"2026071710470224400_pgag239-B32","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1016\/j.cub.2021.06.052","article-title":"Ankyrin-dependent Na(+) channel clustering prevents neuromuscular synapse fatigue","volume":"31","author":"Zhang","year":"2021","journal-title":"Curr Biol"},{"key":"2026071710470224400_pgag239-B33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S0952523813000473","article-title":"Effects of mGluR6-deficiency on photoreceptor ribbon synapse formation: comparison of electron microscopic analysis of serial sections with random sections","volume":"31","author":"Tsukamoto","year":"2014","journal-title":"Vis Neurosci"},{"key":"2026071710470224400_pgag239-B34","doi-asserted-by":"crossref","first-page":"101418","DOI":"10.1016\/j.jbc.2021.101418","article-title":"The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells","volume":"297","author":"Agosto","year":"2021","journal-title":"J Biol Chem"},{"key":"2026071710470224400_pgag239-B35","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(03)00086-2","article-title":"The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina","volume":"37","author":"Dick","year":"2003","journal-title":"Neuron"},{"key":"2026071710470224400_pgag239-B36","first-page":"2690","article-title":"Stability of active zone components at the photoreceptor ribbon complex","volume":"16","author":"Regus-Leidig","year":"2010","journal-title":"Mol Vis"},{"key":"2026071710470224400_pgag239-B37","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1152\/jn.00142.2009","article-title":"Genetic dissection of rod and cone pathways in the dark-adapted mouse retina","volume":"102","author":"Abd-El-Barr","year":"2009","journal-title":"J Neurophysiol"},{"key":"2026071710470224400_pgag239-B38","doi-asserted-by":"crossref","first-page":"17143","DOI":"10.1038\/srep17143","article-title":"Electrophysiological and histological characterization of rod-cone retinal degeneration and microglia activation in a mouse model of mucopolysaccharidosis type IIIB","volume":"5","author":"Tse","year":"2015","journal-title":"Sci Rep"},{"key":"2026071710470224400_pgag239-B39","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1152\/physrev.2001.81.3.1353","article-title":"Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues","volume":"81","author":"Bennett","year":"2001","journal-title":"Physiol Rev"},{"key":"2026071710470224400_pgag239-B40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/19336950.2022.2120467","article-title":"Pleiotropic Ankyrins: scaffolds for ion channels and transporters","volume":"16","author":"Stevens","year":"2022","journal-title":"Channels (Austin)"},{"key":"2026071710470224400_pgag239-B41","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1083\/jcb.142.6.1571","article-title":"Restriction of 480\/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains","volume":"142","author":"Zhang","year":"1998","journal-title":"J Cell Biol"},{"key":"2026071710470224400_pgag239-B42","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.200612012","article-title":"Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms","volume":"177","author":"Dzhashiashvili","year":"2007","journal-title":"J Cell Biol"},{"key":"2026071710470224400_pgag239-B43","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1523\/JNEUROSCI.2661-16.2017","article-title":"Early and late loss of the cytoskeletal scaffolding protein, ankyrin G reveals its role in maturation and maintenance of nodes of ranvier in myelinated axons","volume":"37","author":"Saifetiarova","year":"2017","journal-title":"J Neurosci"},{"key":"2026071710470224400_pgag239-B44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1007005528505","article-title":"Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels","volume":"28","author":"Bennett","year":"1999","journal-title":"J Neurocytol"},{"key":"2026071710470224400_pgag239-B45","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1074\/jbc.M706942200","article-title":"Ankyrin B modulates the function of Na,K-ATPase\/inositol 1,4,5-trisphosphate receptor signaling microdomain","volume":"283","author":"Liu","year":"2008","journal-title":"J Biol Chem"},{"key":"2026071710470224400_pgag239-B46","doi-asserted-by":"crossref","first-page":"e69815","DOI":"10.7554\/eLife.69815","article-title":"Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A","volume":"10","author":"Creighton","year":"2021","journal-title":"Elife"},{"key":"2026071710470224400_pgag239-B47","doi-asserted-by":"crossref","first-page":"102272","DOI":"10.1016\/j.jbc.2022.102272","article-title":"Crystal structure of ankyrin-G in complex with a fragment of neurofascin reveals binding mechanisms required for integrity of the axon initial segment","volume":"298","author":"He","year":"2022","journal-title":"J Biol Chem"},{"key":"2026071710470224400_pgag239-B48","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1083\/jcb.200811086","article-title":"Na+ channels get anchored\u2026with a little help","volume":"183","author":"Rasband","year":"2008","journal-title":"J Cell Biol"},{"key":"2026071710470224400_pgag239-B49","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1126\/science.1169789","article-title":"Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia","volume":"323","author":"Kizhatil","year":"2009","journal-title":"Science"},{"key":"2026071710470224400_pgag239-B50","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1002\/cne.25210","article-title":"Morphological properties of the axon initial segment-like process of AII amacrine cells in the rat retina","volume":"529","author":"Liu","year":"2021","journal-title":"J Comp Neurol"},{"key":"2026071710470224400_pgag239-B51","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.mcn.2004.11.012","article-title":"Novel clustering of sodium channel Na(v)1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina","volume":"28","author":"Van Wart","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"2026071710470224400_pgag239-B52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.exer.2008.09.022","article-title":"Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na\/K-ATPase and the Na\/Ca exchanger in the inner segment of rod photoreceptors","volume":"88","author":"Kizhatil","year":"2009","journal-title":"Exp Eye Res"},{"key":"2026071710470224400_pgag239-B53","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.neuron.2017.02.021","article-title":"The auxiliary calcium channel subunit alpha2delta4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors","volume":"93","author":"Wang","year":"2017","journal-title":"Neuron"},{"key":"2026071710470224400_pgag239-B54","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.cell.2016.07.054","article-title":"Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics","volume":"166","author":"Shekhar","year":"2016","journal-title":"Cell"},{"key":"2026071710470224400_pgag239-B55","doi-asserted-by":"crossref","first-page":"109916","DOI":"10.1016\/j.isci.2024.109916","article-title":"Comprehensive single-cell atlas of the mouse retina","volume":"27","author":"Li","year":"2024","journal-title":"iScience"},{"key":"2026071710470224400_pgag239-B56","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.neuron.2019.04.010","article-title":"Single-cell RNA-seq analysis of retinal development identifies NFI factors as regulating mitotic exit and late-born cell specification","volume":"102","author":"Clark","year":"2019","journal-title":"Neuron"},{"key":"2026071710470224400_pgag239-B57","doi-asserted-by":"crossref","first-page":"ENEURO.0120-23.2024","DOI":"10.1523\/ENEURO.0120-23.2024","article-title":"Cone synaptic function is modulated by the leucine rich repeat (LRR) adhesion molecule LRFN2","volume":"11","author":"Hasan","year":"2024","journal-title":"eNeuro"}],"container-title":["PNAS Nexus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pnasnexus\/advance-article-pdf\/doi\/10.1093\/pnasnexus\/pgag239\/68737084\/pgag239.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pnasnexus\/article-pdf\/5\/7\/pgag239\/68737084\/pgag239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pnasnexus\/article-pdf\/5\/7\/pgag239\/68737084\/pgag239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:47:20Z","timestamp":1784299640000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pnasnexus\/article\/doi\/10.1093\/pnasnexus\/pgag239\/8728954"}},"subtitle":[],"editor":[{"given":"Christof","family":"Niehrs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6,29]]}},"URL":"https:\/\/doi.org\/10.1093\/pnasnexus\/pgag239","relation":{},"ISSN":["2752-6542"],"issn-type":[{"value":"2752-6542","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,6,29]]},"article-number":"pgag239"}}