{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:01:18Z","timestamp":1784919678900,"version":"3.55.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE36-0008"],"award-info":[{"award-number":["ANR-18-CE36-0008"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stuttering is a neurodevelopmental disorder marked by impaired speech production and substantial interindividual variability in symptom severity. Although neuroimaging studies have identified abnormalities in the basal ganglia-thalamocortical circuitry, the specific white matter pathways that underpin dysfluent speech production remain poorly understood. Here, we focus on the frontal aslant tract (FAT), a dorsoventral intralobar tract connecting the superior and inferior frontal cortices and proposed to support both cognitive and motor functions. Using diffusion MRI, we first compared the quantitative anisotropy of the FAT and relevant control tracts in individuals who stutter (n = 30, mean age = 35.67, SD = 13.03) and fluent speakers (n = 22, mean age = 35.64, SD = 10.87) and observed no significant group-level differences in either hemisphere. To delineate the role of FAT subbundles in speech dysfluency, we then segmented the tract at its dorsal and ventral cortical terminations and assessed their relationships with stuttering severity (Stuttering Severity Instrument-Fourth Edition). We identified left FAT subbundles connecting the posteroventral frontal structures, particularly the rostroventral precentral gyrus and, to a lesser extent, the pars opercularis to a dorsal prefrontal region whose integrity predicts stuttering severity. The left-lateralized nature of these associations suggests that stuttering results, in part, from abnormal connectivity between prefrontal systems governing volitional control and the motor circuits engaged in speech production. Together, these findings refine current neurobiological models of stuttering by implicating frontofrontal white matter pathways underlying speech dysfluency and highlight a potential anatomical target for individualized therapeutic interventions.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgag245","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:19:51Z","timestamp":1784276391000},"source":"Crossref","is-referenced-by-count":0,"title":["Reduced integrity in the frontal aslant tract's premotor connections is associated with dysfluency severity in stuttering"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-3067","authenticated-orcid":false,"given":"Ma\u00ebva","family":"Michon","sequence":"first","affiliation":[{"name":"Laboratoire Praxiling, UMR 5267\u2014CNRS, Universit\u00e9 Paul Val\u00e9ry , Montpellier 34000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-4651","authenticated-orcid":false,"given":"Fabrice","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Laboratoire Praxiling, UMR 5267\u2014CNRS, Universit\u00e9 Paul Val\u00e9ry , Montpellier 34000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-2361","authenticated-orcid":false,"given":"Ivana","family":"Didirkov\u00e1","sequence":"additional","affiliation":[{"name":"Laboratoire Praxiling, UMR 5267\u2014CNRS, Universit\u00e9 Paul Val\u00e9ry , Montpellier 34000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-4168","authenticated-orcid":false,"given":"Davide","family":"Giampiccolo","sequence":"additional","affiliation":[{"name":"Department of Epilepsy, UCL Queen Square Institute of Neurology, University College London , London WC1N 3BG ,","place":["United Kingdom"]},{"name":"Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery , London WC1N 3BG ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Monfrais-Pfauwadel","sequence":"additional","affiliation":[{"name":"Laboratoire Praxiling, UMR 5267\u2014CNRS, Universit\u00e9 Paul Val\u00e9ry , Montpellier 34000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Laboratoire Praxiling, UMR 5267\u2014CNRS, Universit\u00e9 Paul Val\u00e9ry , Montpellier 34000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Deverdun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center , Montpellier 34295 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Lebars","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center , Montpellier 34295 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-254X","authenticated-orcid":false,"given":"Guillaume","family":"Herbet","sequence":"additional","affiliation":[{"name":"Laboratoire Praxiling, UMR 5267\u2014CNRS, Universit\u00e9 Paul Val\u00e9ry , Montpellier 34000 ,","place":["France"]},{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center , Montpellier 34295 ,","place":["France"]},{"name":"Institut Universitaire de France , Paris 75005 ,","place":["France"]},{"name":"Department of Medicine, University of Montpellier, Campus ADV , Montpellier 34090 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"2026072414220999200_pgag245-B1","article-title":"Adult stuttering prevalence II: recalculation, subgrouping and estimate of stuttering community engagement","volume":"83","author":"Gattie","year":"2025","journal-title":"J Fluen Disord"},{"key":"2026072414220999200_pgag245-B2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jfludis.2012.11.002","article-title":"Epidemiology of stuttering: 21st century advances","volume":"38","author":"Yairi","year":"2013","journal-title":"J Fluen Di-sord"},{"key":"2026072414220999200_pgag245-B3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jfludis.2017.03.007","article-title":"A systematic literature review of neuroimaging research on developmental stuttering between 1995 and 2016","volume":"55","author":"Etchell","year":"2018","journal-title":"J Fluen 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mutations in people who stutter","volume":"3","author":"Chow","year":"2021","journal-title":"Brain Commun"},{"key":"2026072414220999200_pgag245-B8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1162\/nol_a_00017","article-title":"Linking lysosomal enzyme targeting genes and energy metabolism with altered gray matter volume in children with persistent stuttering","volume":"1","author":"Chow","year":"2020","journal-title":"Neurobiol Lang"},{"key":"2026072414220999200_pgag245-B9","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1093\/brain\/awad314","article-title":"Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40","volume":"146","author":"Morgan","year":"2023","journal-title":"Brain"},{"key":"2026072414220999200_pgag245-B10","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2019.03088","article-title":"Involvement of the cortico-basal ganglia-thalamocortical loop in developmental 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