{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:52:05Z","timestamp":1778799125250,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1176","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ankylosing spondylitis (AS) is a chronic inflammatory arthritis primarily affecting the sacroiliac joint and axial skeleton with associated extra-articular involvement including cardiovascular system disease including aortic valve disease with variable reported prevalence. The aim of this study is to determine the prevalence of heart valve disorders in AS patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective, population-based, cross-sectional study that retrieved data from the Clalit Health Services registry. Cases were defined as having AS, whereas controls were frequency matched by age and sex in a ratio of 5:1. The prevalence of valvular heart diseases was compared between the two groups; a multivariate logistic regression model was applied to estimate the association after controlling for potential confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 4082 AS patients and 20\u2009397 controls frequency matched by age and sex. AS patients had a significantly higher prevalence of cardiovascular risk factors (P\u2009&amp;lt;\u2009.001) and a higher prevalence of valvular heart disease. In the multivariate logistic regression model, adjusting for multiple confounding factors, AS was independently associated with aortic stenosis [odds ratio (OR): 2.25, 95% confidence interval (CI): 1.57\u20133.23, P\u2009&amp;lt;\u20090.001], aortic insufficiency (OR: 2.44, 95% CI: 1.50\u20133.94, P\u2009&amp;lt;\u20090.001), and mitral insufficiency (OR: 1.75, 95% CI: 1.17\u20132.61, P\u2009&amp;lt;\u20090.001) but not mitral stenosis (OR: 1.31, 95% CI: 0.60\u20132.70, P\u2009=\u20090.47).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study reports the increased risk of valvular heart diseases in patients with AS, possibly due to the inflammatory milieu associated with the disease process and the result of biomechanical stress affecting the enthesis-like valvular structures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgad045","type":"journal-article","created":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T15:05:43Z","timestamp":1686495943000},"page":"1088-1093","source":"Crossref","is-referenced-by-count":11,"title":["Ankylosing spondylitis is associated with increased prevalence of valvular heart diseases: a cross-sectional population-based study"],"prefix":"10.1093","volume":"99","author":[{"given":"Siwar","family":"Eid","sequence":"first","affiliation":[{"name":"Tel Aviv University Sackler Faculty of Medicine, , Tel Aviv 69978 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kassem","family":"Sharif","sequence":"additional","affiliation":[{"name":"Tel Aviv University Sackler Faculty of Medicine, , Tel Aviv 69978 , Israel"},{"name":"Sheba Medical Center Department of Medicine \u2018B\u2019, Zabludowicz Center for Autoimmune Diseases, , Tel Hashomer 5262100 , Israel"},{"name":"Sheba Medical Center Department of Gastroenterology, , Tel Hashomer 5262100 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[{"name":"Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital Section of Musculoskeletal Disease, NIHR Leeds Musculoskeletal Biomedical Research Centre, , Leeds LS7 4SA , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonatan Shneor","family":"Patt","sequence":"additional","affiliation":[{"name":"Tel Aviv University Sackler Faculty of Medicine, , Tel Aviv 69978 , Israel"},{"name":"Sheba Medical Center Department of Medicine \u2018B\u2019, Zabludowicz Center for Autoimmune Diseases, , Tel Hashomer 5262100 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avishai M","family":"Tsur","sequence":"additional","affiliation":[{"name":"Sheba Medical Center Department of Medicine \u2018B\u2019, Zabludowicz Center for Autoimmune Diseases, , Tel Hashomer 5262100 , Israel"},{"name":"Sheba Medical Center Department of Gastroenterology, , Tel Hashomer 5262100 , Israel"},{"name":"Israel Defense Forces, Tel Hashomer Medical Corps, , Ramat Gan , Israel"},{"name":"Hebrew University of Jerusalem Department of Military Medicine, Faculty of Medicine, , Jerusalem 9190401 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Adawi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Bar Ilan University , Ramat Gan 5290002 , Israel"},{"name":"Puria Medical Center Rheumatology Unit, , Tiberias 1712 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon D","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clalit Health Services Chief Physicians Office, , Tel Aviv 6209804 , Israel"},{"name":"Ben-Gurion University of the Negev Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, , Beer Sheva 84105 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Amital","sequence":"additional","affiliation":[{"name":"Sheba Medical Center Department of Medicine \u2018B\u2019, Zabludowicz Center for Autoimmune Diseases, , Tel Hashomer 5262100 , Israel"},{"name":"Sheba Medical Center Department of Gastroenterology, , Tel Hashomer 5262100 , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulla","family":"Watad","sequence":"additional","affiliation":[{"name":"Sheba Medical Center Department of Medicine \u2018B\u2019, Zabludowicz Center for Autoimmune Diseases, , Tel Hashomer 5262100 , Israel"},{"name":"Sheba Medical Center Department of Gastroenterology, , Tel Hashomer 5262100 , Israel"},{"name":"Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital Section of Musculoskeletal Disease, NIHR Leeds Musculoskeletal Biomedical Research Centre, , Leeds LS7 4SA , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,10]]},"reference":[{"key":"2023092221061495600_ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/bmj.38954.689583.DE","article-title":"Diagnosis and management of ankylosing spondylitis","volume":"333","author":"McVeigh","year":"2006","journal-title":"BMJ"},{"key":"2023092221061495600_ref2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/2040622317743486","article-title":"New advances in the understanding and treatment of axial spondyloarthritis: from chance to choice","volume":"9","author":"Dubash","year":"2018","journal-title":"Ther Adv Chronic Dis"},{"key":"2023092221061495600_ref3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s003930050215","article-title":"Inception cohorts for spondyloarthropathies","volume":"59","author":"Braun","year":"2000","journal-title":"Z 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German Collaborative Arthritis Centers","volume":"27","author":"Zink","year":"2000","journal-title":"J Rheumatol"},{"key":"2023092221061495600_ref5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejim.2018.04.002","article-title":"The link between COPD and ankylosing spondylitis: a population based study","volume":"53","author":"Sharif","year":"2018","journal-title":"Eur J Intern Med"},{"key":"2023092221061495600_ref6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrrheum.2010.79","article-title":"Pathogenesis of ankylosing spondylitis","volume":"6","author":"Tam","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"2023092221061495600_ref7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrrheum.2015.147","article-title":"\u2018MHC-I-opathy\u2019\u2014unified concept for spondyloarthritis and Beh\u00e7et disease","volume":"11","author":"McGonagle","year":"2015","journal-title":"Nat Rev 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