{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:38:10Z","timestamp":1769744290035,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1182","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Foundation of Zhejiang Provincial Education Department","award":["Y202146832"],"award-info":[{"award-number":["Y202146832"]}]},{"name":"Foundation of Zhejiang Provincial Education Department","award":["Y202249328"],"award-info":[{"award-number":["Y202249328"]}]},{"name":"Science and Technology Program of Jinhua Science and Technology Bureau","award":["2020-4-104"],"award-info":[{"award-number":["2020-4-104"]}]},{"name":"Science and Technology Program of Yiwu Science and Technology Bureau","award":["2020-3-059"],"award-info":[{"award-number":["2020-3-059"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Temporal trends and risk factors of perioperative cardiac events (PCEs) in patients over 80\u00a0years old with coronary artery disease (CAD) undergoing noncardiac surgery are still unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively reviewed 1478 patients over 80\u00a0years old, with known CAD undergoing selective noncardiac surgery in a single center (2014\u20132022). Patients were divided into three equal time groups based on the discharge date (2014\u20132016, 2017\u20132019, and 2020\u20132022), with 367, 473, and 638 patients in Groups 1\u20133, respectively. Perioperative clinical variables were extracted from the electronic medical records database. The primary outcome was the occurrence of PCEs intraoperatively or during hospitalization postoperatively, defined as any of the following events: myocardial infarction, heart failure, nonfatal cardiac arrest, and death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>PCEs occurred in 180 (12.2%) patients. Eight independent risk factors were associated with PCEs, including four clinical factors (body mass index &amp;lt; 22\u00a0kg\/m2, history of myocardial infarction, history of heart failure, and general anesthesia) and four preoperative laboratory results (hemoglobin &amp;lt; 110\u00a0g\/L, albumin &amp;lt; 40\u00a0g\/L, creatinine &amp;gt; 120\u00a0\u03bcmol\/L, and potassium &amp;lt;3.6\u00a0mmol\/L). Significant rising trends were seen over the 9-year study period in the incidence of PCEs and independent risk factors including history of myocardial infarction, history of heart failure, general anesthesia, preoperative hemoglobin &amp;lt; 110\u00a0g\/L, preoperative albumin &amp;lt; 40\u00a0g\/L, and preoperative creatinine &amp;gt; 120\u00a0\u03bcmol\/L (P for trend &amp;lt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The incidence and independent risk factors of PCEs in patients over 80\u00a0years old with CAD undergoing noncardiac surgery showed significant rising trends over the last 9-year period.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgad141","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T09:24:27Z","timestamp":1705310667000},"page":"252-261","source":"Crossref","is-referenced-by-count":3,"title":["Temporal trends and risk factors of perioperative cardiac events in patients over 80\u00a0years old with coronary artery disease undergoing noncardiac surgery: a high-volume single-center experience, 2014\u20132022"],"prefix":"10.1093","volume":"100","author":[{"given":"Xiaolin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition , The Fourth Affiliated Hospital, , N1 Shangcheng Road, Yiwu, 322000 Zhejiang , People\u2019s Republic of China"},{"name":"Zhejiang University School of Medicine , The Fourth Affiliated Hospital, , N1 Shangcheng Road, Yiwu, 322000 Zhejiang , People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The Fourth Affiliated Hospital, , N1 Shangcheng Road, Yiwu, 322000 Zhejiang , People\u2019s Republic of China"},{"name":"Zhejiang University School of Medicine , The Fourth Affiliated Hospital, , N1 Shangcheng Road, Yiwu, 322000 Zhejiang , People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-7072","authenticated-orcid":false,"given":"Yunpeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology , The Fourth Affiliated Hospital, , N1 Shangcheng Road, Yiwu, 322000 Zhejiang , People\u2019s Republic of China"},{"name":"Zhejiang University School of Medicine , The Fourth Affiliated Hospital, , N1 Shangcheng Road, Yiwu, 322000 Zhejiang , People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"2024031821305038000_ref1","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0140-6736(15)60806-6","article-title":"Estimate of the global volume of surgery in 2012: an assessment supporting improved health outcomes","volume":"385","author":"Weiser","year":"2015","journal-title":"Lancet"},{"key":"2024031821305038000_ref2","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The world report on ageing and health: a policy framework for healthy ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet"},{"key":"2024031821305038000_ref3","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s00268-016-3845-y","article-title":"Compliance with guidelines of enhanced recovery after surgery in elderly patients undergoing gastrectomy","volume":"41","author":"Jeong","year":"2017","journal-title":"World J Surg"},{"key":"2024031821305038000_ref4","volume":"120","journal-title":"Anesthesiology"},{"key":"2024031821305038000_ref5","volume":"35","journal-title":"Eur J Intern Med"},{"key":"2024031821305038000_ref6","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2147\/CIA.S252160","article-title":"Perioperative cardiac complications in patients over 80 years of age with coronary artery disease undergoing noncardiac surgery: the incidence and risk factors","volume":"15","author":"Liu","year":"2020","journal-title":"Clin Interv Aging"},{"key":"2024031821305038000_ref7","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1161\/CIR.0000000000000105","article-title":"2014 ACC\/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"130","author":"Fleisher","year":"2014","journal-title":"Circulation"},{"key":"2024031821305038000_ref8","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1161\/CIR.0b013e3182776f83","article-title":"2012 ACCF\/AHA\/ACP\/AATS\/PCNA\/SCAI\/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons","volume":"126","author":"Fihn","year":"2012","journal-title":"Circulation"},{"key":"2024031821305038000_ref9","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction","volume":"60","author":"Thygesen","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2024031821305038000_ref10","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2024031821305038000_ref11","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/jama.2019.1696","article-title":"In-hospital cardiac arrest: a review","volume":"321","author":"Andersen","year":"2019","journal-title":"JAMA"},{"key":"2024031821305038000_ref12","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.jacc.2015.09.026","article-title":"Cardiac risk of noncardiac surgery","volume":"66","author":"Patel","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2024031821305038000_ref13","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1056\/NEJMoa1401106","article-title":"Clonidine in patients undergoing noncardiac surgery","volume":"370","author":"Devereaux","year":"2014","journal-title":"N Engl J Med"},{"key":"2024031821305038000_ref14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41569-020-0410-z","article-title":"Non-cardiac surgery in patients with coronary artery disease: risk evaluation and periprocedural management","volume":"18","author":"Cao","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2024031821305038000_ref15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ihj.2017.08.010","article-title":"Incidence and predictors of perioperative myocardial infarction in patients undergoing non-cardiac surgery in a tertiary care hospital","volume":"70","author":"Sunny","year":"2018","journal-title":"Indian Heart J"},{"key":"2024031821305038000_ref16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/anae.14138","article-title":"Cardiovascular complications after non-cardiac surgery","volume":"73","author":"Sellers","year":"2018","journal-title":"Anaesthesia"},{"key":"2024031821305038000_ref17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCULATIONAHA.110.011130","article-title":"Mortality and readmission of patients with heart failure, atrial fibrillation, or coronary artery disease undergoing noncardiac surgery: an analysis of 38 047 patients","volume":"124","author":"van Diepen","year":"2011","journal-title":"Circulation"},{"key":"2024031821305038000_ref18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4097\/kjae.2017.70.1.3","article-title":"Perioperative management of left ventricular diastolic dysfunction and heart failure: an anesthesiologist's perspective","volume":"70","author":"Ryu","year":"2017","journal-title":"Korean J Anesthesiol"},{"key":"2024031821305038000_ref19","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1093\/eurheartj\/ehac270","article-title":"2022 ESC guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery","volume":"43","author":"Halvorsen","year":"2022","journal-title":"Eur Heart J"},{"key":"2024031821305038000_ref20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.100.10.1043","article-title":"Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery","volume":"100","author":"Lee","year":"1999","journal-title":"Circulation"},{"key":"2024031821305038000_ref21","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1016\/j.jacc.2019.04.023","article-title":"A new index for pre-operative cardiovascular evaluation","volume":"73","author":"Dakik","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2024031821305038000_ref22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018013","article-title":"Development and validation of a prediction model for stroke, cardiac, and mortality risk after non-cardiac surgery","volume":"10","author":"Woo","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2024031821305038000_ref23","article-title":"Development and validation of predictive model-HASBLAD score-for major adverse cardiovascular events during perioperative period of non-cardiac surgery: a single Center experience in China","volume":"9","author":"Zhao","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2024031821305038000_ref24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41746-022-00625-6","article-title":"Multi-center validation of machine learning model for preoperative prediction of postoperative mortality","volume":"5","author":"Lee","year":"2022","journal-title":"NPJ Digit Med"},{"issue":"1018\u201326","key":"2024031821305038000_ref25","first-page":"1029","article-title":"A case-cohort study of postoperative myocardial infarction: impact of anemia and cardioprotective medications","volume":"156","author":"Henke","year":"2014","journal-title":"Surgery"},{"key":"2024031821305038000_ref26","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1089\/end.2012.0665","article-title":"The impact of body mass index on perioperative outcomes in robot-assisted laparoscopic partial nephrectomy","volume":"27","author":"Kiziloz","year":"2013","journal-title":"J Endourol"},{"key":"2024031821305038000_ref27","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut-off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"2024031821305038000_ref28","first-page":"1020","article-title":"Relation between serum creatinine and postoperative results of open-heart surgery","volume":"34","author":"Ezeldin","year":"2013","journal-title":"Saudi Med J"},{"key":"2024031821305038000_ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12603-021-1714-3","article-title":"Nutritional status and renal function in relation to frailty among the community-dwelling elderly Taiwanese population","volume":"26","author":"Chang","year":"2022","journal-title":"J Nutr Health Aging"},{"key":"2024031821305038000_ref30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1515\/cclm-2016-0038","article-title":"Preoperative serum potassium predicts the clinical outcome after non-cardiac surgery","volume":"55","author":"Arora","year":"2017","journal-title":"Clin Chem Lab Med"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/100\/1182\/252\/57006685\/qgad141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/100\/1182\/252\/57006685\/qgad141.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T22:11:06Z","timestamp":1710799866000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/100\/1182\/252\/7517675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,14]]},"references-count":30,"journal-issue":{"issue":"1182","published-online":{"date-parts":[[2024,1,14]]},"published-print":{"date-parts":[[2024,3,18]]}},"URL":"https:\/\/doi.org\/10.1093\/postmj\/qgad141","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,1,14]]}}}