{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:35:41Z","timestamp":1775705741967,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1183","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["20KJB320012"],"award-info":[{"award-number":["20KJB320012"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The evaluation of patients with fatty liver as defined by metabolic dysfunction-associated fatty liver disease (MAFLD) in the real world remains poorly researched. This study aimed to analyse the clinical and histological features of patients with MAFLD and nonalcoholic fatty liver disease (NAFLD) and to characterize each metabolic subgroup of MAFLD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 2563 patients with fatty liver confirmed by ultrasonography and\/or magnetic resonance tomography and\/or liver biopsy-proven from three hospitals in China were included in the study. Patients were divided into different groups according to diagnostic criteria for MAFLD and NAFLD, and MAFLD into different subgroups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 2337 (91.2%) patients fitting the MAFLD criteria, and 2095 (81.7%) fitting the NAFLD criteria. Compared to patients with NAFLD, those with MAFLD were more likely to be male, had more metabolic traits, higher liver enzyme levels, and noninvasive fibrosis scores. Among the patients with liver biopsy, the extent of advanced fibrosis in cases with MAFLD was significantly higher than those with NAFLD, 31.8% versus 5.2% (P\u2009&amp;lt;\u2009.001); there was no significant difference in advanced fibrosis between obese cases and lean individuals in MAFLD (P\u2009&amp;gt;\u2009.05); MAFLD complicated with diabetes had significantly higher advanced fibrosis than those without diabetes (43.3% and 17.2%, respectively; P\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with MAFLD have a higher degree of liver fibrosis than NAFLD patients. In addition, diabetic patients should be screened for fatty liver and liver fibrosis degree.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae007","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:44:56Z","timestamp":1706229896000},"page":"319-326","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic dysfunction-associated fatty liver disease and nonalcoholic fatty liver disease from clinical to pathological characteristics: a multi-center cross-sectional study in real world"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9840-7138","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Graduate School of Xuzhou Medical University , Xuzhou, Jiangsu, 221004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyong","family":"Dai","sequence":"additional","affiliation":[{"name":"Graduate School of Xuzhou Medical University , Xuzhou, Jiangsu, 221004 , China"},{"name":"Department of Infectious Diseases, Huaian Hospital of Huaian City , Huaian, Jiangsu, 223200 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Ruan","sequence":"additional","affiliation":[{"name":"Graduate School of Xuzhou Medical University , Xuzhou, Jiangsu, 221004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate School of Xuzhou Medical University , Xuzhou, Jiangsu, 221004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Graduate School of Xuzhou Medical University , Xuzhou, Jiangsu, 221004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School , Nanjing, Jiangsu, 210008 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School of Xuzhou Medical University , Xuzhou, Jiangsu, 221004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjia","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Infection and Hepatology, Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu, 221002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungui","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Infection and Hepatology, Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu, 221002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infection and Hepatology, Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu, 221002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School , Nanjing, Jiangsu, 210008 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Infection and Hepatology, Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu, 221002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Liver Disease, Affiliated Wuxi Fifth Hospital of Jiangnan University , Wuxi, Jiangsu, 214011 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9802-8890","authenticated-orcid":false,"given":"Fang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Infection and Hepatology, Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu, 221002 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"2024042216432863200_ref1","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1210\/clinem\/dgac321","article-title":"Global prevalence and clinical characteristics of metabolic-associated fatty liver disease: a meta-analysis and systematic review of 10 739 607 individuals","volume":"107","author":"Chan","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"2024042216432863200_ref2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41575-022-00635-5","article-title":"Metabolic 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