{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:52:37Z","timestamp":1788976357607,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1185","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic inflammation has been connected by epidemiological evidence to coronary artery disease (CAD) along with myocardial infarction (MI). Nevertheless, it is still unclear whether reverse causality or confounders account for these connections. Our objectives are to examine the causality between inflammatory cytokines and CAD\/MI as well as the potential mediating influence of lipid characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We acquired instrumental variables through genome-wide association studies meta-analyses of 41 inflammatory cytokines (8293 individuals). Genetic associations with CAD (122\u2009733 cases and 424\u2009528 controls), MI (~61\u2009505 cases and 577\u2009716 controls) and five candidate lipid mediators were obtained from the corresponding genome-wide association studies. A two-step, two-sample Mendelian randomization analysis was applied, followed with comprehensive sensitivity analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Genetically determined growth regulated oncogene-\u03b1 was causally linked to a decreased incidence of CAD [odds ratio (OR), 0.97; 95% confidence interval (CI), 0.95-0.99; P\u2009=\u2009.007] and MI (OR, 0.95; 95% CI, 0.92-0.98; P\u2009=\u2009.002). There is suggestive evidence indicating a causal impact of macrophage inflammatory protein-1\u03b2 upon CAD (OR, 1.04; 95% CI, 1.01\u20131.07; P\u2009=\u2009.010) and MI (OR, 1.07; 95% CI, 1.02\u20131.11; P\u2009=\u2009.002). Furthermore, we discovered suggestive causal connections between tumor necrosis factor-related apoptosis-inducing ligand and CAD (OR, 0.97; 95% CI, 0.95\u20131.00; P\u2009=\u2009.020). Two-step Mendelian randomization analysis revealed that triglycerides partially mediate the effect of growth regulated oncogene-\u03b1 on CAD (proportion-mediated: 13.28%) and MI (8.05%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We provided novel genetic evidence supporting the causality of inflammatory cytokines on CAD\/MI and elucidate the mediating effect of triglycerides in the causal pathways linking inflammatory cytokines and CAD\/MI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae017","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T05:59:52Z","timestamp":1709013592000},"page":"461-468","source":"Crossref","is-referenced-by-count":7,"title":["Genetic effects of inflammatory cytokines on coronary artery disease and myocardial infarction and the mediating roles of lipid traits"],"prefix":"10.1093","volume":"100","author":[{"given":"Junsong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Ningbo University, School of Medicine, Ningbo University , Ningbo, Zhejiang 315010 , China"},{"name":"Cardiovascular Disease Clinical Medical Research Center of Ningbo , Ningbo, Zhejiang 315010 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Ningbo University, School of Medicine, Ningbo University , Ningbo, Zhejiang 315010 , China"},{"name":"Cardiovascular Disease Clinical Medical Research Center of Ningbo , Ningbo, Zhejiang 315010 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0733-5707","authenticated-orcid":false,"given":"Teng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Ningbo University, School of Medicine, Ningbo University , Ningbo, Zhejiang 315010 , China"},{"name":"Cardiovascular Disease Clinical Medical Research Center of Ningbo , Ningbo, Zhejiang 315010 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"2024062822391036000_ref1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jacc.2019.08.012","article-title":"From subclinical atherosclerosis to plaque progression and acute coronary events: JACC state-of-the-art review","volume":"74","author":"Ahmadi","year":"2019","journal-title":"J Am Coll 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