{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:54:24Z","timestamp":1791219264238,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1187","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shandong Medical Association 2021","award":["YXH2021ZX011"],"award-info":[{"award-number":["YXH2021ZX011"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH365"],"award-info":[{"award-number":["ZR2021MH365"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To investigate the impacts of remimazolam tosilate on gastrointestinal hormones and motility in patients undergoing gastrointestinal endoscopy with sedation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 262 American Society of Anesthesiologists Physical Status I or II patients, aged 18\u201365\u00a0years, scheduled for gastrointestinal endoscopy with sedation, were randomly allocated into two groups (n\u2009=\u2009131 each): the remimazolam tosilate group (Group R) and the propofol group (Group P). Patients in Group R received 0.2\u20130.25\u00a0mg\/Kg remimazolam tosilate intravenously, while those in Group P received 1.5\u20132.0\u00a0mg\/kg propofol intravenously. The gastrointestinal endoscopy was performed when the Modified Observer\u2019s Assessment of Alertness\/Sedation scores were\u2009\u22643. The primary endpoints included the endoscopic intestinal peristalsis rating by the endoscopist; serum motilin and gastrin levels at fasting without gastrointestinal preparation (T0), before gastrointestinal endoscopy (T1), and before leaving the Post Anesthesia Care Unit (T2); and the incidences of abdominal distension during Post Anesthesia Care Unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with Group P, intestinal peristalsis rating was higher in Group R (P\u2009&amp;lt;\u2009.001); Group R showed increased motilin and gastrin levels at T2 compared with Group P (P\u2009&amp;lt;\u2009.01). There was a rise in motilin and gastrin levels at T1 and T2 compared with T0 and at T2 compared with T1 in both groups (P\u2009&amp;lt;\u2009.01). The incidence of abdominal distension was lower in Group R (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with propofol used during gastrointestinal endoscopy with sedation, remimazolam tosilate mildly inhibits the serum motilin and gastrin levels, potentially facilitating the recovery of gastrointestinal motility.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae040","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T03:59:22Z","timestamp":1711598362000},"page":"635-641","source":"Crossref","is-referenced-by-count":5,"title":["Effects of remimazolam tosilate on gastrointestinal hormones and gastrointestinal motility in patients undergoing gastrointestinal endoscopy with sedation: a randomized control 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