{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:29:36Z","timestamp":1740133776960,"version":"3.37.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1187","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH112-122"],"award-info":[{"award-number":["KSVGH112-122"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2023-C-004"],"award-info":[{"award-number":["CSH-2023-C-004"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The pathogenesis of atopic dermatitis (AD) remains unclear. Nontyphoidal Salmonella (NTS) infection might trigger immune-mediated reactions. We aimed to examine NTS and the risk of subsequent AD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From 2002 to 2015, eligible patients (aged 0\u2013100 years) with NTS were identified. NTS and non-NTS groups were matched at a 1:10 ratio on age and sex. We utilized conditional multivariable Cox proportional hazard models to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) for AD development. Subgroup analyses were conducted based on age, sex, and severity of NTS infection. We utilized landmark analysis to explore the time-dependent hazard of AD following NTS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the NTS group (N = 6624), 403 developed AD. After full adjustment of demographics and comorbidities, the NTS group had a higher risk of AD than the reference group (aHR = 1.217, 95% CI = 1.096\u20131.352). Age-stratified analysis revealed that NTS group exhibited an elevated risk compared to the reference group, particularly among those aged 13\u201330 years (aHR = 1.25, 95% CI = 1.017\u20131.559), individuals aged 31\u201350 years (aHR = 1.388, 95% CI = 1.112\u20131.733), those aged 51\u201370 years (aHR = 1.301, 95% CI = 1.008\u20131.679), and individuals aged 71 years and over (aHR = 1.791, 95% CI = 1.260\u20132.545). Severe NTS was associated with a higher risk of AD than the reference group (aHR = 2.411, 95% CI = 1.577\u20133.685). Landmark analysis showed generally consistent findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Minimizing exposure to NTS infection may represent a prospective strategy for averting the onset and progression of atopic dermatitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae041","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T23:04:26Z","timestamp":1712099066000},"page":"649-656","source":"Crossref","is-referenced-by-count":1,"title":["Time-dependent risk of atopic dermatitis following nontyphoidal <i>Salmonella<\/i> infection"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-2233","authenticated-orcid":false,"given":"Renin","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research , Kaohsiung Veterans General Hospital, Kaohsiung 81362 , Taiwan"},{"name":"Department of Emergency Medicine , Kaohsiung Veterans General Hospital, Kaohsiung 40201 , Taiwan"},{"name":"School of Medicine , Chung Shan Medical University, Taichung 95050 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University , Taichung 40201 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Min","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Nephrology , Department of Internal Medicine, Taipei Veterans General Hospital Taitung Branch, 40201 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University , Taichung 40201 , Taiwan"},{"name":"Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Cheng-Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University , Taichung 40201 , Taiwan"},{"name":"Division of Allergy , Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung 40432 , Taiwan"},{"name":"Department of Nursing, Chung Shan Medical University , Taichung 40721 , Taiwan"},{"name":"Graduate Institute of Integrated Medicine , China Medical University, Taichung , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"2024081911463535000_ref1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/all.13320","article-title":"The prevalence of atopic dermatitis beyond childhood: a systematic review and meta-analysis of longitudinal 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