{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:41:06Z","timestamp":1769881266080,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1189","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073229"],"award-info":[{"award-number":["82073229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>The aim of the present study is to explore the possible association between periodontitis and upper gastrointestinal (UGI) cancers, including esophageal and gastric cancers, utilizing the Mendelian randomization method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this research, we utilized the Mendelian randomization method to examine the causal association between periodontitis and UGI cancers. Genome-wide association studies data for periodontitis were obtained from the Gene-Lifestyle Interactions in Dental Endpoints consortium, while UGI cancers\u2019 data were accessed from FinnGen\u2019s Biobank. After rigorously screening instrumental variables for periodontitis, we analyzed them with UGI cancers primarily using the inverse variance weighted. Finally, to identify outliers, the results were subjected to a leave-one-out sensitivity analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Inverse variance weighted (fixed effect) results revealed that periodontitis is a risk factor for gastric cancer (OR\u2009=\u20091.7735, 95% CI: 1.1576 to 2.7170, P\u2009=\u20090.0085). As for esophageal cancer, no statistically significant correlation was observed. Furthermore, no outliers were detected in any of the results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our two-sample Mendelian randomization study obviously demonstrates a significant positive association between periodontitis and gastric cancer, while no statistically significant correlation was found for esophageal cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae069","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T09:33:52Z","timestamp":1717666432000},"page":"820-826","source":"Crossref","is-referenced-by-count":2,"title":["Two-sample Mendelian randomization analysis of the relationship between periodontitis and risk of upper gastrointestinal cancers"],"prefix":"10.1093","volume":"100","author":[{"given":"Shuyi","family":"Mi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine , No.88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang, 310009,","place":["China"]},{"name":"Institute of Gastroenterology, Zhejiang University , Hangzhou, Zhejiang, 310009,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine , No.88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang, 310009,","place":["China"]},{"name":"Institute of Gastroenterology, Zhejiang University , Hangzhou, Zhejiang, 310009,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine , No.88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang, 310009,","place":["China"]},{"name":"Institute of Gastroenterology, Zhejiang University , Hangzhou, Zhejiang, 310009,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine , No.88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang, 310009,","place":["China"]},{"name":"Institute of Gastroenterology, Zhejiang University , Hangzhou, Zhejiang, 310009,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"2024110711581039800_ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2024110711581039800_ref2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0757.2010.00359.x","article-title":"Comparative biology of chronic and aggressive periodontitis: introduction","volume":"53","author":"Armitage","year":"2010","journal-title":"Periodontol"},{"key":"2024110711581039800_ref3","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J Periodontol"},{"key":"2024110711581039800_ref4","first-page":"15","article-title":"Periodontitis and risk of cancer: mechanistic evidence","volume":"2000","author":"Baima","year":"2023","journal-title":"Periodontol"},{"key":"2024110711581039800_ref5","doi-asserted-by":"crossref","first-page":"901098","DOI":"10.3389\/fonc.2022.901098","article-title":"Periodontal disease and cancer risk: a nationwide population-based cohort study","volume":"12","author":"Kim","year":"2022","journal-title":"Front Oncol"},{"key":"2024110711581039800_ref6","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.3390\/cancers15153974","article-title":"Chronic periodontitis and the potential likelihood of gastric cancer: a nested case-control study in the Korean population utilizing a national health sample cohort","volume":"15","author":"Kwon","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2024110711581039800_ref7","doi-asserted-by":"crossref","first-page":"e0195683","DOI":"10.1371\/journal.pone.0195683","article-title":"Is periodontitis a risk indicator for cancer? 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