{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T14:08:15Z","timestamp":1747058895584,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1189","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019832","name":"Gal\u00e1pagos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019832","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005565","name":"Janssen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and aims<\/jats:title>\n                  <jats:p>Familial inflammatory bowel disease (IBD) history is a controversial prognostic factor in IBD. We aimed to evaluate the impact of a familial history of IBD on the use of medical and surgical treatments in the biological era.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients included in the prospectively maintained ENEIDA database and diagnosed with IBD after 2005 were included. Familial forms were defined as those cases with at least one first-degree relative diagnosed with IBD. Disease phenotype, the use of biological agents, or surgical treatments were the main outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 5263 patients [2627 Crohn\u2019s disease (CD); 2636 ulcerative colitis (UC)] were included, with a median follow-up of 31\u00a0months. Of these, 507 (10%) corresponded to familial forms. No clinical differences were observed between familial and sporadic IBD forms except a lower age at IBD diagnosis and a higher rate of males in familial forms of UC. In CD, the proportions of patients treated with thiopurines (54.4% vs 46.7%; P\u2009=\u2009.015) and survival time free of thiopurines (P\u2009=\u2009.009) were lower in familial forms. No differences were found regarding the use of biological agents. Concerning surgery, a higher rate of intestinal resections was observed in sporadic CD (14.8% vs 9.9%, P\u2009=\u2009.027). No differences were observed in UC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In the era of biological therapies, familial and sporadic forms of IBD show similar phenotypes and are managed medically in a similar way; whether these is due to lack of phenotypical differences or an effect of biological therapies is uncertain.<\/jats:p>\n                  <jats:p>What is already known on this topic: IBD\u2019s etiopathogenesis points to an interaction between environmental and genetic factors, being familial history a controversial prognostic factor. Biological agents use and need for surgery regarding familial or sporadic forms of IBDs present conflicting results. What this study adds: Familial and sporadic forms of IBD have similar phenotypes and are managed medically and surgically in a similar way. How this study might affect research, practice or policy: Familial aggregation should not be considered a factor associated with more aggressive disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae076","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T15:41:22Z","timestamp":1719243682000},"page":"836-844","source":"Crossref","is-referenced-by-count":1,"title":["Influence of familial forms of inflammatory bowel disease on the use of immunosuppressants, biological agents, and surgery in the era of biological therapies. Results from the ENEIDA project"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-3449","authenticated-orcid":false,"given":"Carlos","family":"Gonz\u00e1lez-Mu\u00f1oza","sequence":"first","affiliation":[{"name":"H. Santa Creu i Sant Pau (Gastroenterology Department, Barcelona, Spain)"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona (Barcelona, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margalida","family":"Calafat","sequence":"additional","affiliation":[{"name":"H. Universitari Germans Trias i Pujol (Gastroenterology Department, Badalona, Spain) and CIBEREHD (Madrid, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier P","family":"Gisbert","sequence":"additional","affiliation":[{"name":"H. de La Princesa (Gastroenterology Department, Madrid) and Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP, Madrid, Spain), Universidad Aut\u00f3noma de Madrid (UAM, Madrid, Spain) and CIBEREHD (Madrid, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Iglesias","sequence":"additional","affiliation":[{"name":"H. Universitario Reina Sof\u00eda (Gastroenterology Department, C\u00f3rdoba, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"M\u00ednguez","sequence":"additional","affiliation":[{"name":"H.Cl\u00ednico Valencia (Gastroenterology Department, Valencia, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Sicilia","sequence":"additional","affiliation":[{"name":"H. Universitario de Burgos (Gastroenterology Department, Burgos, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Aceituno","sequence":"additional","affiliation":[{"name":"H. Universitari M\u00fatua Terrassa (Gastroenterology Department, Terrassa, Spain) and CIBEREHD (Madrid, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Gomoll\u00f3n","sequence":"additional","affiliation":[{"name":"H.Cl\u00ednico Universitario Lozano Blesa (Gastroenterology Department, Zaragoza, Spain) and CIBEREHD (Madrid, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Calvet","sequence":"additional","affiliation":[{"name":"H. Parc Taul\u00ed (Gastroenterology Department, Sabadell, Spain) and CIBEREHD (Madrid, Spain)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ricart","sequence":"additional","affiliation":[{"name":"H. 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