{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:08:22Z","timestamp":1792786102671,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1191","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Henan Province Traditional Chinese Medicine Scientific Research Special Project"},{"name":"Henan Province Science and Technology Research Program"},{"name":"\u201cZhang Zhongjing Inheritance and Innovation Special Project\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune inflammation is intricately associated with coronary artery disease (CAD) progression, necessitating the pursuit of more efficacious therapeutic strategies. This study aimed to uncover potential therapeutic targets for CAD and myocardial infarction (MI) by elucidating the causal connection between regulatory immune-related genes (RIRGs) and these disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>We performed summary data-based Mendelian randomization analysis to assess the therapeutic targets linked to expression quantitative trait loci and methylation quantitative trait loci of RIRGs in relation to CAD and MI. Independent validation cohorts and datasets from coronary artery and left ventricular heart tissue were analyzed. To strengthen causal inference, colocalization analysis and PhenoScanner phenotype scans were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Utilizing multiomics integration, we pinpointed EIF2B2, FCHO1, and DDT as CAD risk genes. Notably, EIF2B2 and FCHO1 displayed significant associations with MI. High EIF2B2 expression, regulated by cg16144293, heightened CAD and MI risk at rs175438. In contrast, enhanced FCHO1 expression, modulated by cg18329931, reduced CAD and MI risk at rs13382133. DDT upregulation influenced by cg11060661 and cg09664220 was associated with decreased CAD risk at rs5760120. Colocalization analysis firmly established these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EIF2B2, FCHO1, and DDT represent risk loci for CAD progression within RIRGs. Our identification of these genes enhances understanding of CAD pathogenesis and directs future drug development efforts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgae105","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:39:54Z","timestamp":1723102794000},"page":"50-59","source":"Crossref","is-referenced-by-count":3,"title":["The impact of immunity on the risk of coronary artery disease: insights from a multiomics study"],"prefix":"10.1093","volume":"101","author":[{"given":"Rutao","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhengzhou Hospital of Traditional Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]},{"name":"The Affiliated Zhengzhou Hospital of Traditional Chinese Medicine, Henan University of Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhengzhou Hospital of Traditional Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]},{"name":"The Affiliated Zhengzhou Hospital of Traditional Chinese Medicine, Henan University of Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhengzhou Hospital of Traditional Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]},{"name":"The Affiliated Zhengzhou Hospital of Traditional Chinese Medicine, Henan University of Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhengzhou Hospital of Traditional Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]},{"name":"The Affiliated Zhengzhou Hospital of Traditional Chinese Medicine, Henan University of Chinese Medicine , Zhengzhou, Henan 450000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"2024122317355598900_ref1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(22)02079-7","article-title":"Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal 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