{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:59:55Z","timestamp":1789675195543,"version":"4.0.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1192","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Guangzhou Science and Technology Plan Project","award":["2023A03J0526"],"award-info":[{"award-number":["2023A03J0526"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To systematically review the effect of vitamin D supplementation on diabetic foot ulcer (DFU) healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed, Web of Science, Science direct, Ebsco host, CNKI, WanFang, VIP, and CBM databases were electronically searched to collect randomized controlled trials (RCTs) on the impact of vitamin D supplementation on DFUs from inception to 19 November 2022. Two researchers independently screened the literature, extracted the data and assessed the risk of bias of the included studies. Meta-analysis was then performed by using RevMan 5.3 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of seven studies involving 580 patients were included. The results of meta-analysis showed that compared with control group, the wound healing efficiency rate (RR\u2009=\u20091.42, 95%CI 1.03 to 1.95, P\u00a0=\u20090.03) and wound reduction rate (MD\u2009=\u200913.11, 95%CI 4.65 to 21.56, P &amp;lt; 0.01) of the experimental group were higher; the change values of the wound area (MD\u2009=\u2009\u22123.29, 95%CI \u22124.89 to 1.70, P &amp;lt; 0.01) and 25 (OH) D (MD\u2009=\u20099.63, 95%CI 6.96 to 12.31, P &amp;lt; 0.01) were larger. Supplementation of vitamin D on DFU patients can improve glucose metabolism and insulin indexes: hemoglobin A1c (MD\u2009=\u2009\u22120.44, 95%CI -0.62 to \u22120.26, P &amp;lt; 0.01), fasting insulin (MD\u2009=\u2009\u22123.75, 95%CI \u22125.83 to \u22121.67, P &amp;lt; 0.01), HOMA - \u03b2 (MD\u2009=\u2009\u22125.14, 95%CI \u22128.74 to \u22121.54, P &amp;lt; 0.01), and quantitative insulin sensitivity check index (MD\u2009=\u20090.02, 95%CI 0.01 to 0.02, P &amp;lt; 0.01). It can also improve inflammation and oxidative stress markers: high sensitivity C-reactive protein (MD\u2009=\u2009\u22120.83, 95%CI \u22121.06 to \u22120.59, P &amp;lt; 0.01), erythrocyte sedimentation rate (MD\u2009=\u2009\u221215.74, 95%CI \u221221.78 to \u22129.71, P&amp;lt;0.01), nitric oxide (MD\u2009=\u20091.81, 95%CI 0.07 to 3.55, P\u00a0=\u20090.04), and malondialdehyde (MD\u2009=\u2009\u22120.43, 95%CI -0.61 to \u22120.24, P&amp;lt;0.01). There was no statistically significant difference in changes of fasting plasma glucose, homeostasis model of assessment-insulin resistance, total antioxidant capacity, glutathione, very low density lipoprotein cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol (P&amp;gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current evidence suggests that vitamin D supplementation can significantly promote DFU healing by lowering blood sugar and alleviating inflammation and oxidative stress.<\/jats:p>\n                    <jats:p>Key messages What is already known on this topic\u00a0 Diabetic foot ulcer (DFU) is a major complication of diabetes mellitus, with high morbidity, mortality and resource utilization. Vitamin D has the effect of lowering blood sugar, improving insulin sensitivity, and increasing anti-inflammatory response. Clinical research on vitamin D supplementation for the treatment of DFU is increasing, but due to the lack of combing and integration, the actual efficacy of vitamin D in patients is unclear. What this study adds\u00a0 This meta-analysis has shown that vitamin D supplementation can significantly promote DFU healing by lowering blood glucose and alleviating inflammation and oxidative stress. How this study might affect research, practice or policy\u00a0 This study preliminarily found the effectiveness of vitamin D supplementation on the healing of DFU, which can provide a reference for the treatment of DFU by medical staff.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgae107","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:43:08Z","timestamp":1724370188000},"page":"100-107","source":"Crossref","is-referenced-by-count":12,"title":["Effects of vitamin D supplementation on diabetic foot ulcer healing: a meta-analysis"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6095-0964","authenticated-orcid":false,"given":"Xiaokun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nursing, Foshan Hospital of Traditional Chinese Medicine , 6 Qinren Road, Chancheng District, Foshan 528099,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Obstetrics Department, Shenzhen Baoan Women's and Children's Hospital , 56 Yulu Road, Bao'an District, Shenzhen 518102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Ye","sequence":"additional","affiliation":[{"name":"Burn and Wound Repair Center, Guangzhou Red Cross Hospital of Jinan University , 396 Tongfu Middle Road, Haizhu District, Guangzhou 510220,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmiao","family":"Peng","sequence":"additional","affiliation":[{"name":"Burn and Wound Repair Center, Guangzhou Red Cross Hospital of Jinan University , 396 Tongfu Middle Road, Haizhu District, Guangzhou 510220,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Lan","sequence":"additional","affiliation":[{"name":"School of Nursing, Guangdong Pharmaceutical University , 283 Jianghai Avenue, Haizhu Distric, Guangzhou 510315,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guangzhou Red Cross Hospital of Jinan University , 396 Tongfu Middle Road, Haizhu District, Guangzhou 510220,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Outpatient, Guangzhou Red Cross Hospital of Jinan University , 396 Tongfu Middle Road, Haizhu District, Guangzhou 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