{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:42:08Z","timestamp":1769830928265,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1192","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Strengthening and Promoting Traditional Chinese Medicine","award":["HKGYQYXM-2022-06"],"award-info":[{"award-number":["HKGYQYXM-2022-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the speed of achieving painless uterine contractions in parturients undergoing epidural analgesia at different lumbar puncture levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study is a randomized controlled trial at a tertiary A hospital with a history of over 80\u00a0years in Sichuan Province, China. Parturients aged 22\u201340\u00a0years old scheduled for vaginal delivery under epidural analgesia were recruited. Eligible patients were randomly allocated into lumbar 2-3 (L2-3) or lumbar 3-4 (L3-4) groups. Epidural analgesia was performed through the interspaces according to grouping. The primary outcome was the percentage of painless uterine contractions 15\u00a0min after the initiation of analgesia. The secondary outcomes included the percentage of painless status at 5 and 10\u00a0min, sensory block plane, motor block evaluation, adverse events of parturients, epidural analgesic consumption, Apgar score, and the parturients' evaluation of analgesia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between April 2023 and August 2023, a total of 150 women were finally recruited, and 136 of them were analyzed (68 in each group). In comparison with the L3-4 groups, there was a significantly larger proportion of painless uterine contractions at 5, 10, and 15\u00a0min after analgesia initiation in the L2-3 group (20.6% vs. 7.4%, 52.9% vs. 26.5%, and 80.9% vs. 64.7%, P\u2009=\u2009.026, .002, and .034, respectively). Similarly, the pain scores were lower in the L2-3 group at 5, 10, and 15\u00a0min than that in the L3-4 group (5(4,7) vs. 6(5,7), 3(2,5) vs. 4(3,6), and 2(1,3) vs. 3(2,5), P\u2009=\u2009.006, .004, and .020, respectively). Furthermore, puncturing through the L2-3 interspace contributed to a higher evaluation of parturients to the analgesia procedure (9(8,9) vs. 8(8,9), P\u2009&amp;lt;\u2009.001). However, there was no significant difference in sensory block, motor block, or adverse events between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Puncturing through the L2-3 interspace is associated with faster pain relief and a better experience for parturients. These findings present a superior option for anesthesiologists when conducting epidural labor analgesia.<\/jats:p>\n                  <jats:p>Key messages What is already known on this topic?\u00a0 Epidural analgesia is an effective way to relieve labor pain. What this study adds?\u00a0 Puncturing via lumbar 2-3 interspace induces more rapid onset of epidural analgesia. How this study might affect research, practice or policy?\u00a0 Lumbar 2-3 interspace is a superior option in terms of the speed of pain relief and satisfaction of parturients when conducting epidural labor analgesia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae116","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:17:48Z","timestamp":1725149868000},"page":"116-122","source":"Crossref","is-referenced-by-count":3,"title":["Role of lumbar puncture level on the onset of epidural labor analgesia: a randomized controlled trial"],"prefix":"10.1093","volume":"101","author":[{"given":"Rui","family":"Zhou","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation , Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, , No. 1279, Sanmen Road, Hongkou District, Shanghai 200434,","place":["China"]},{"name":"Shanghai Fourth People's Hospital, School of Medicine, Tongji University , Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, , No. 1279, Sanmen Road, Hongkou District, Shanghai 200434,","place":["China"]},{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuansheng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhu","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Deyang People's Hospital , No. 173, Section 1 of North Taishan North Road, Deyang 618000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lize","family":"Xiong","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation , Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, , No. 1279, Sanmen Road, Hongkou District, Shanghai 200434,","place":["China"]},{"name":"Shanghai Fourth People's Hospital, School of Medicine, Tongji University , Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, , No. 1279, Sanmen Road, Hongkou District, Shanghai 200434,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"2025061406170474800_ref1","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1097\/AOG.0000000000003132","article-title":"ACOG practice bulletin No. 209: obstetric analgesia and Anesthesia","volume":"133","year":"2019","journal-title":"Obstet 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