{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:17:57Z","timestamp":1748405877289,"version":"3.41.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1196","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30880"],"award-info":[{"award-number":["2022JJ30880"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["B202304127273"],"award-info":[{"award-number":["B202304127273"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ20091"],"award-info":[{"award-number":["2023JJ20091"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High Level Health Talents in Hunan Province","award":["20240304082"],"award-info":[{"award-number":["20240304082"]}]},{"name":"Third Xiangya Hospital of Central South University","award":["YX202007"],"award-info":[{"award-number":["YX202007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship between different types of emotions and inflammatory dermatoses is lacking. This study is aimed to investigate the causal relationship between negative emotions and inflammatory dermatoses through Mendelian randomization (MR) analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Summary data of seven negative emotions were obtained from a genome-wide association study (GWAS) conducted by the MRC-IEU consortium. Seven inflammatory dermatoses including vitiligo, psoriasis, systemic lupus erythematosus, eczema, atopic dermatitis, acne, and rosacea were obtained from published GWAS. The MR analysis primarily employed the Inverse variance weighted (IVW) method, and supplemented by MR-Egger and other three MR methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The IVW method revealed that guilty feelings have potential to increase the risk of psoriasis (OR\u2009=\u20091.02, 95% CI: 1.00\u20131.05, P\u2009=\u20090.019), while worrier\/anxious feelings have a potential risk effect on eczema (OR\u2009=\u20091.07, 95% CI: 1.00\u20131.13, P\u2009=\u20090.042). Psoriasis could increase the occurrence of miserableness (OR\u2009=\u20091.41, 95% CI: 1.18\u20131.68, P\u2009=\u20090.0001), worrier\/anxious feelings (OR\u2009=\u20091.26, 95% CI: 1.02\u20131.57, P\u2009=\u20090.033), nervous feelings (OR\u2009=\u20091.25, 95% CI: 1.05\u20131.49, P\u2009=\u20090.012), and loneliness\/isolation (OR\u2009=\u20091.19, 95% CI: 1.04\u20131.36, P\u2009=\u20090.009). Eczema might cause an increased incidence of worrier\/anxious feelings (OR\u2009=\u20091.038, 95% CI: 1.007\u20131.070, P\u2009=\u20090.014).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This MR study revealed bidirectional causality between worrier\/anxious feelings and eczema. It also found that guilty feelings may elevate the risk of psoriasis, and individuals with psoriasis may experience increased rates of miserableness, worrier\/anxious feelings, nervous feelings, and loneliness\/isolation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae173","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:34:42Z","timestamp":1733873682000},"page":"511-516","source":"Crossref","is-referenced-by-count":1,"title":["The causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9253-7646","authenticated-orcid":false,"given":"Keyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuhan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University , Changsha 410013, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"2025052713442817500_ref1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jdv.14373","article-title":"Molecular and cellular discoveries in inflammatory dermatoses","volume":"31","author":"Soumelis","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025052713442817500_ref2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12916-023-02948-x","article-title":"Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK","volume":"21","author":"Henderson","year":"2023","journal-title":"BMC Med"},{"key":"2025052713442817500_ref3","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/jdv.19813","article-title":"The mind-skin connection: a narrative review exploring the link between inflammatory skin diseases and psychological stress","volume":"38","author":"Biazus Soares","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025052713442817500_ref4","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.3390\/healthcare10101913","article-title":"Prospective analysis of the temporal relationship between psychological distress and atopic dermatitis in female adults: a preliminary study","volume":"10","author":"Birdi","year":"2022","journal-title":"Healthcare (Basel, Switzerland)"},{"key":"2025052713442817500_ref5","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.jad.2020.11.110","article-title":"Protective effects of anti-depressants against the subsequent development of psoriasis in patients with major depressive disorder: a cohort study","volume":"281","author":"Tzeng","year":"2021","journal-title":"J Affect Disord"},{"key":"2025052713442817500_ref6","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"2025052713442817500_ref7","first-page":"65","article-title":"Experience with psoriasis in a psychosomatic dermatology clinic","volume":"186","author":"Polenghi","year":"1994","journal-title":"Acta Derm Venereol Suppl"},{"key":"2025052713442817500_ref8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.anai.2020.07.007","article-title":"The impact of psychological stress on mast cells","volume":"125","author":"Theoharides","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025052713442817500_ref9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1210\/endo.139.1.5660","article-title":"Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects","volume":"139","author":"Theoharides","year":"1998","journal-title":"Endocrinology"},{"key":"2025052713442817500_ref10","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jaci.2015.01.033","article-title":"Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis","volume":"136","author":"Mashiko","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2025052713442817500_ref11","first-page":"339","article-title":"Endocrinology of the skin: intradermal neuroimmune network, a new frontier","volume":"30","author":"Caraffa","year":"2016","journal-title":"J Biol Regul Homeost Agents"},{"key":"2025052713442817500_ref12","doi-asserted-by":"publisher","first-page":"e2306772","DOI":"10.1002\/advs.202306772","article-title":"Cutaneous calcium\/calmodulin-dependent protein kinase II-\u03b3-positive sympathetic nerves secreting norepinephrine dictate psoriasis","volume":"11","author":"Yu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2025052713442817500_ref13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cyto.2017.05.018","article-title":"IL-17A causes depression-like symptoms via NF\u03baB and p38MAPK signaling pathways in mice: implications for psoriasis associated depression","volume":"97","author":"Nadeem","year":"2017","journal-title":"Cytokine"},{"key":"2025052713442817500_ref14","doi-asserted-by":"publisher","first-page":"299","DOI":"10.2340\/00015555-1273","article-title":"Living with psoriasis: prevalence of shame, anger, worry, and problems in daily activities and social life","volume":"92","author":"Sampogna","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"2025052713442817500_ref15","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.jaci.2005.09.050","article-title":"Stress and atopic disorders","volume":"116","author":"Wright","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"2025052713442817500_ref16","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jaip.2019.08.030","article-title":"Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study","volume":"8","author":"Schonmann","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025052713442817500_ref17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1093\/bjd\/ljad110","article-title":"Circulating biomarkers are associated with disease severity of chronic hand eczema and atopic dermatitis","volume":"189","author":"Quaade","year":"2023","journal-title":"Br J Dermatol"},{"key":"2025052713442817500_ref18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.18176\/jiaci.0682","article-title":"Dupilumab: a review of present indications and off-label uses","volume":"32","author":"Mu\u00f1oz-Bellido","year":"2022","journal-title":"J Investig Allergol Clin Immunol"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/101\/1196\/511\/60989608\/qgae173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/101\/1196\/511\/60989608\/qgae173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T17:44:32Z","timestamp":1748367872000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/101\/1196\/511\/7919158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":18,"journal-issue":{"issue":"1196","published-online":{"date-parts":[[2024,12,9]]},"published-print":{"date-parts":[[2025,5,18]]}},"URL":"https:\/\/doi.org\/10.1093\/postmj\/qgae173","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"type":"print","value":"0032-5473"},{"type":"electronic","value":"1469-0756"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2024,12,9]]}}}