{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:00:35Z","timestamp":1776427235914,"version":"3.51.2"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1197","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Thyroid cancer primarily affects young women and raises concerns about future fertility due to treatments of thyroidectomy and radioactive iodine (RAI) therapy. This study investigated the effects of these treatments on pregnancy probability in young female patients post-diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A nationwide, population-based study using data from Taiwan\u2019s National Health Insurance Research Database (2000\u20132017) examined pregnancy likelihood in women \u226445\u00a0years with thyroid cancer. The effects of thyroidectomy and RAI therapy on pregnancy were analyzed using logistic regression and Cox proportional-hazards models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a cohort of 10\u2009937 patients with thyroid cancer, 7022 (64.2%) underwent total thyroidectomy, with 718 receiving RAI treatment. The type of thyroidectomy and RAI treatment, even at doses exceeding 120 millicuries, did not reduce the likelihood of pregnancy. Age was identified as the most critical factor influencing pregnancy; women aged &amp;gt;30\u00a0years had a significantly lower likelihood of becoming pregnant than younger women did. Other factors associated with a reduced likelihood of pregnancy included comorbidity with diabetes (HR\u2009=\u20090.65, P\u2009=\u2009.002) and higher socioeconomic status (HR\u2009=\u20090.69, P\u2009=\u2009.085).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Thyroidectomy and RAI therapy do not diminish pregnancy probability in young women with thyroid cancer. Age remains a crucial factor, with younger women more likely to conceive. These findings are critical for fertility counseling and treatment planning.<\/jats:p>\n                  <jats:p>Key message What is already known on this subjec?\u00a0 Thyroid cancer primarily affects young women, and its standard treatments, including thyroidectomy and radioactive iodine (RAI) therapy, have raised concerns about their potential impact on fertility. Previous studies have shown that RAI treatment may temporarily affect ovarian function but typically does not have a significant long-term effect on fertility. What this study adds?\u00a0 This nationwide population-based study found that neither total nor partial thyroidectomy, nor RAI treatment, adversely affects the likelihood of pregnancy in young women with thyroid cancer. Age was identified as the most significant factor influencing pregnancy, with younger women having a higher probability of becoming pregnant after treatment. How this study might affect research, practice, or policy?\u00a0 Clinicians should recognize that age, rather than the type of thyroidectomy or RAI treatment, is the most critical factor influencing fertility in young women with thyroid cancer. This insight can guide personalized fertility counseling and treatment planning to optimize outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/postmj\/qgae197","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T08:41:16Z","timestamp":1736498476000},"page":"636-643","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy among thyroid cancer survivors: do thyroidectomy and radioactive iodine matter?"],"prefix":"10.1093","volume":"101","author":[{"given":"Chung-Jen","family":"Teng","sequence":"first","affiliation":[{"name":"Division of Oncology and Hematology, Department of Medicine, Far Eastern Memorial Hospital , No. 21, Sec. 2, Nanya S. Road, Banqiao District, New Taipei City 22060 ,","place":["Taiwan"]},{"name":"Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Yang Ming Campus , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu-Mei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Yang Ming Campus , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]},{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 11217, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Yang Ming Campus , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]},{"name":"Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University, Yang Ming Campus , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzeng-Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Taipei Veterans General Hospital Hsinchu Branch , No. 81, Sec. 1, Zhongfeng Road, Zhudong Township, Hsinchu County 31064 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Yang Ming Campus , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 11217 ,","place":["Taiwan"]},{"name":"Institute of Hospital and Health Care Administration, College of Medicine, National Yang Ming Chiao Tung University, Yang Ming Campus , No. 155, Sec. 2, Linong Street, Beitou District, Taipei 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