{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:29:29Z","timestamp":1769178569363,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1204","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of peripheral nerve injury has increased annually and it has become a common traumatic disease in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Netrin-1 is a crucial extracellular matrix protein that plays a significant role in nerve development and regeneration, and is involved in the construction of a local neurological injury regional regeneration and repair microenvironment to support axon and myelin repair growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recent studies have highlighted its important roles in the repair of peripheral nerve injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review clarifies how Netrin-1 in fluences neuronal survival, promotes axonal regeneration, and modulates neuro-inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgaf080","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:36:02Z","timestamp":1747035362000},"page":"123-129","source":"Crossref","is-referenced-by-count":0,"title":["Netrin-1: pioneering new Frontiers in peripheral nerve injury treatment"],"prefix":"10.1093","volume":"102","author":[{"given":"Chun","family":"Qin","sequence":"first","affiliation":[{"name":"Graduate School of Naval Medical University , No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433 ,","place":["China"]},{"name":"Department of Intensive Care Medicine, Army 72nd Group Army Hospital , No. 9, Station Road, Wuxing District, Huzhou City, Zhejiang Province, 313000 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University , 168 Changhai Road, Yangpu District, Shanghai, 200433 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University , 168 Changhai Road, Yangpu District, Shanghai, 200433 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingtong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University , 168 Changhai Road, Yangpu District, Shanghai, 200433 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Army 72nd Group Army Hospital , No. 9, Station Road, Wuxing District, Huzhou City, Zhejiang Province, 313000 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"Graduate School of Shanghai University of Sport , 399 Changhai Road, Yangpu District, Shanghai, 200438 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University , 168 Changhai Road, Yangpu District, Shanghai, 200433 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"2026012308321535400_ref1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.5578\/tt.20219904","article-title":"Association of plasma netrin-1 level with inflammatory balance and comorbidities in patients with acute exacerbation of COPD. KOAH akut alevlenme hastalar\u0131nda plasma netrin-1 d\u00fczeyinin inflamatuar denge ve komorbiditeler \u00fczerine etkisi","volume":"69","author":"Kerget","year":"2021","journal-title":"Tuberk Toraks"},{"key":"2026012308321535400_ref2","doi-asserted-by":"publisher","first-page":"8248","DOI":"10.3390\/ijms22158248","article-title":"Netrin-1 in glioblastoma neovascularization: The new partner in crime?","volume":"22","author":"V\u00e1squez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026012308321535400_ref3","doi-asserted-by":"publisher","first-page":"e22997","DOI":"10.7759\/cureus.22997","article-title":"Risk for persistent peripheral neuropathy after repair of brachial artery injuries","volume":"14","author":"Loewenstein","year":"2022","journal-title":"Cureus."},{"key":"2026012308321535400_ref4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/rapm-2022-104113","article-title":"The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: A scoping review of the literature","volume":"48","author":"Brenna","year":"2023","journal-title":"Reg Anesth Pain Med"},{"key":"2026012308321535400_ref5","doi-asserted-by":"publisher","first-page":"e259","DOI":"10.1097\/jnr.0000000000000530","article-title":"Factors associated with peripheral nerve injury after pelvic laparoscopy: The importance of surgical positioning","volume":"31","author":"Zarandona Del Campo","year":"2023","journal-title":"J Nurs Res"},{"key":"2026012308321535400_ref6","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s00115-023-01550-z","article-title":"Die Wahl der richtigen Bildgebung zur Diagnostik und Verlaufsbeurteilung peripherer Nervenverletzungen [choosing the right imaging for the diagnostics and assessment of the course of peripheral nerve injuries]","volume":"94","author":"B\u00fcrkle","year":"2023","journal-title":"Nervenarzt."},{"key":"2026012308321535400_ref7","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.3390\/jpm12101548","article-title":"Modern MRI diagnostics of upper-extremity-related nerve injuries-a prospective multi-Center study protocol for diagnostics and follow up of peripheral nerve injuries","volume":"12","author":"Aman","year":"2022","journal-title":"J Pers Med"},{"key":"2026012308321535400_ref8","doi-asserted-by":"publisher","first-page":"1434429","DOI":"10.3389\/fneur.2024.1434429","article-title":"A systematic review of steroid use in peripheral nerve pathologies and treatment","volume":"15","author":"Couch","year":"2024","journal-title":"Front Neurol"},{"key":"2026012308321535400_ref9","doi-asserted-by":"publisher","first-page":"101982","DOI":"10.1016\/j.jormas.2024.101982","article-title":"Netrin 1 as a biomarker in cancer: Scoping diagnostic, prognostic, and therapeutic perspectives with a focus on oral squamous cell carcinoma","volume":"125","author":"K","year":"2024","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"2026012308321535400_ref10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.canlet.2021.05.034","article-title":"UNC5 dependence receptor family in human cancer: A controllable double-edged sword","volume":"516","author":"Zhu","year":"2021","journal-title":"Cancer Lett"},{"key":"2026012308321535400_ref11","doi-asserted-by":"publisher","first-page":"e3382","DOI":"10.1002\/jgm.3382","article-title":"Inhibition of the long non-coding RNA UNC5B-AS1\/miR-4455\/RSPO4 axis reduces cervical cancer growth in vitro and in vivo","volume":"23","author":"Fu","year":"2021","journal-title":"J Gene Med"},{"key":"2026012308321535400_ref12","doi-asserted-by":"publisher","first-page":"10090","DOI":"10.3390\/ijms221810090","article-title":"Netrin-1 as a multitarget barrier stabilizer in the peripheral nerve after injury","volume":"22","author":"Chen","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026012308321535400_ref13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/1440-1681.13430","article-title":"Local uncoordinated gene 5H2 contributes to nerve injury-induced mechanical allodynia associated to its role in autophagy","volume":"48","author":"Chen","year":"2021","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2026012308321535400_ref14","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1007\/s12035-022-02861-z","article-title":"UNC5B overexpression alleviates peripheral neuropathic pain by stimulating Netrin-1-dependent autophagic flux in Schwann cells","volume":"59","author":"Xiao","year":"2022","journal-title":"Mol Neurobiol"},{"key":"2026012308321535400_ref15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1021\/acsami.0c16391","article-title":"Aligned graphene mesh-supported double network natural hydrogel conduit loaded with Netrin-1 for peripheral nerve regeneration","volume":"13","author":"Huang","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026012308321535400_ref16","doi-asserted-by":"publisher","first-page":"eadm8454","DOI":"10.1126\/sciadv.adm8454","article-title":"Netrin-1-engineered endothelial cell exosomes induce the formation of pre-regenerative niche to accelerate peripheral nerve repair","volume":"10","author":"Huang","year":"2024","journal-title":"Sci Adv"},{"key":"2026012308321535400_ref17","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.2174\/1570159X20666220302150723","article-title":"Netrin-1 in post-stroke neuroprotection: Beyond axon guidance cue","volume":"20","author":"Luo","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"2026012308321535400_ref18","doi-asserted-by":"publisher","first-page":"e23623","DOI":"10.1002\/jbt.23623","article-title":"Netrin-1 protects blood-brain barrier (BBB) integrity after cerebral ischemia-reperfusion by activating the Kruppel-like factor 2 (KLF2)\/occludin pathway","volume":"38","author":"Li","year":"2024","journal-title":"J Biochem Mol Toxicol"},{"key":"2026012308321535400_ref19","doi-asserted-by":"publisher","first-page":"150870","DOI":"10.1016\/j.bbrc.2024.150870","article-title":"Pinocembrin alleviates LPS-induced depressive- like behavior in mice via the NLRP3\/DCC signaling pathway","volume":"736","author":"Wu","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"2026012308321535400_ref20","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.bioactmat.2024.04.019","article-title":"Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis","volume":"39","author":"Shu","year":"2024","journal-title":"Bioact Mater"},{"key":"2026012308321535400_ref21","doi-asserted-by":"publisher","first-page":"102219","DOI":"10.1016\/j.tice.2023.102219","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells loaded with RVG-Lamp2b and Netrin-1 promotes Schwann cell invasion and migration","volume":"85","author":"He","year":"2023","journal-title":"Tissue Cell"},{"key":"2026012308321535400_ref22","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cytogfr.2022.01.003","article-title":"Netrin-1: An emerging player in inflammatory diseases","volume":"64","author":"Xia","year":"2022","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026012308321535400_ref23","doi-asserted-by":"publisher","first-page":"9271","DOI":"10.1007\/s11033-020-05996-1","article-title":"Netrin-1 protects the SH-SY5Y cells against amyloid beta neurotoxicity through NF-\u03baB\/Nrf2 dependent mechanism","volume":"47","author":"Zamani","year":"2020","journal-title":"Mol Biol Rep"},{"key":"2026012308321535400_ref24","doi-asserted-by":"publisher","first-page":"751570","DOI":"10.3389\/fnmol.2021.751570","article-title":"Netrin-1 ameliorates postoperative delirium-like behavior in aged mice by suppressing neuroinflammation and restoring impaired blood-brain barrier permeability","volume":"14","author":"Li","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"2026012308321535400_ref25","first-page":"1049","article-title":"Netrin-1: pioneering new Frontiers in peripheral nerve injury treatment","volume":"30","author":"Zhu","year":"2022","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi."},{"key":"2026012308321535400_ref26","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12964-022-00935-y","article-title":"Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis","volume":"20","author":"Huang","year":"2022","journal-title":"Cell Commun Signal"},{"key":"2026012308321535400_ref27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3892\/ijo.2019.4931","article-title":"UNC5C-knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin \u03b16\/\u03b24 signaling pathway","volume":"56","author":"Yuan","year":"2020","journal-title":"Int J Oncol"},{"key":"2026012308321535400_ref28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/4193309","article-title":"High-glucose-induced injury to proximal tubules of the renal system is alleviated by Netrin-1 suppression of Akt\/mTOR","volume":"2023","author":"Liu","year":"2023","journal-title":"J Diabetes Res"},{"key":"2026012308321535400_ref29","doi-asserted-by":"publisher","first-page":"960","DOI":"10.4103\/NRR.NRR-D-23-01573","article-title":"Netrin-1 signaling pathway mechanisms in neurodegenerative diseases","volume":"20","author":"Zhu","year":"2025","journal-title":"Neural Regen Res"},{"key":"2026012308321535400_ref30","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1158\/0008-5472.CAN-18-1590","article-title":"Netrin-1 and its receptor DCC are causally implicated in melanoma progression","volume":"80","author":"Boussouar","year":"2020","journal-title":"Cancer Res"},{"key":"2026012308321535400_ref31","doi-asserted-by":"publisher","first-page":"e2103319118","DOI":"10.1073\/pnas.2103319118","article-title":"\u039440p53 isoform up-regulates netrin- 1\/UNC5B expression and potentiates netrin-1 pro-oncogenic activity","volume":"118","author":"Sun","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012308321535400_ref32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41586-023-06372-2","article-title":"Pharmacological targeting of netrin-1 inhibits EMT in cancer","volume":"620","author":"Lengrand","year":"2023","journal-title":"Nature."},{"key":"2026012308321535400_ref33","doi-asserted-by":"publisher","first-page":"e12878","DOI":"10.15252\/emmm.202012878","article-title":"Targeting netrin-3 in small cell lung cancer and neuroblastoma","volume":"13","author":"Jiang","year":"2021","journal-title":"EMBO Mol Med"},{"key":"2026012308321535400_ref34","doi-asserted-by":"publisher","first-page":"1178638","DOI":"10.3389\/fimmu.2023.1178638","article-title":"Netrin-1 controls inflammation in response to ischemic stroke through altering microglia phenotype","volume":"14","author":"Yang","year":"2023","journal-title":"Front Immunol"},{"key":"2026012308321535400_ref35","doi-asserted-by":"publisher","first-page":"e18241","DOI":"10.1111\/jcmm.18241","article-title":"Research progress of the netrins and their receptors in cancer","volume":"28","author":"Gao","year":"2024","journal-title":"J Cell Mol Med"},{"key":"2026012308321535400_ref36","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ihj.2021.11.186","article-title":"Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-a pilot study","volume":"74","author":"Inderjeet","year":"2022","journal-title":"Indian Heart J"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/102\/1204\/123\/64857936\/qgaf080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/102\/1204\/123\/64857936\/qgaf080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:32:22Z","timestamp":1769175142000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/102\/1204\/123\/8297174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":36,"journal-issue":{"issue":"1204","published-online":{"date-parts":[[2025,10,22]]},"published-print":{"date-parts":[[2026,1,23]]}},"URL":"https:\/\/doi.org\/10.1093\/postmj\/qgaf080","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2025,10,22]]}}}