{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:29:21Z","timestamp":1779301761041,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1202","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000030","name":"US Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["T42 OH00841"],"award-info":[{"award-number":["T42 OH00841"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"US National Institute on Aging","award":["5R37AG027343"],"award-info":[{"award-number":["5R37AG027343"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A growing number of studies have reported that occupational psychosocial factors increase the risk of cardiovascular disease. Allostatic load (AL) is a main biological mechanism that explains the pathway from stress to disease. This study examined whether work-to-family conflict (WFC) and family-to-work conflict (FWC) at baseline would be associated with changes in the AL index (ALI) across four years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the Midlife in Japan survey, Wave I, and the biomarker projects, Waves I and II. This study included 152 participants with paid jobs and variables of interest at baseline and target biomarkers at baseline and follow-up. We examined the four-year longitudinal changes in the ALI using two methods: comparing ALI scores at baseline and follow-up, named \u201cTwo ALI approach,\u201d and creating one ALI score considering changes at baseline and follow-up, named \u201cOne ALI approach.\u201d Negative binomial regression analysis and generalized estimating equations were used for analyses. The results were reported by count ratios (CRs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the final model, our results demonstrated that WFC at baseline was significantly associated with increased ALI using the \u201cTwo ALI approach\u201d (CR 1.15, 95% CIs: 1.03, 1.28) and \u201cOne ALI approach\u201d (CR 1.15, 95% CIs: 1.01, 1.32), whereas FWC did not show statistical significance in both methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WFC was longitudinally associated with increased ALI. It is crucial to mitigate the effects of work-to-family conflict.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgaf101","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:50:10Z","timestamp":1749628210000},"page":"1303-1310","source":"Crossref","is-referenced-by-count":1,"title":["Does work\u2013family conflict predict allostatic load? A 4-year longitudinal study"],"prefix":"10.1093","volume":"101","author":[{"given":"Mayumi","family":"Saiki","sequence":"first","affiliation":[{"name":"School of Nursing, University of California Los Angeles , 700 Tiverton Avenue, Los Angeles 90095 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Loerbroks","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of D\u00fcsseldorf , Universit\u00e4tsstra\u00dfe 1, D\u00fcsseldorf 40225 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2614-4291","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing, University of California Los Angeles , 700 Tiverton Avenue, Los Angeles 90095 ,","place":["United States"]},{"name":"Departments 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