{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:56:54Z","timestamp":1792090614587,"version":"4.4.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1206","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to examine the relationship between markers indicating systemic inflammatory response and epicardial fat volume (EFV) detected by computed tomography (CT) in type 2 diabetes mellitus (T2DM) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 165 patients (92 patients with diabetes and 73 control group) who underwent thoracic CT examination were included in the study. Hemogram parameters, lipid profiles, HbA1c, glucose, C-reactive protein, and uric acid levels were recorded. The systemic inflammatory response was calculated using the formula P\u2009\u00d7\u2009N\/L. CT images were analysed by an experienced radiologist using 3D Slicer software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EFV and surface area were significantly higher in T2DM patients compared to the control group (P\u2009&amp;lt;\u2009.001). Additionally, the uric acid to HDL ratio (UHR) and systemic inflammatory index (SII) values of T2DM patients were significantly higher than those of control subjects (P\u2009=\u2009.04 for UHR and P\u2009=\u2009.035 for SII). Receiver operating characteristic analysis showed that EFV was &amp;gt;15.5 in T2DM patients with a sensitivity of 92% and a specificity of 37%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reveals that EFV is higher in T2DM patients and shows a positive correlation SII. Evaluating EFV, SII, and UHR together may be significant in assessing the inflammatory burden and cardiac risk of T2DM. The ease and cost-effectiveness of these markers increase their usability in clinical practice.<\/jats:p>\n                    <jats:p>Key messages What is already known on this topic: Epicardial fat volume (EFV) and systemic inflammatory index (SII) have been reported to be associated with type 2 diabetes mellitus (T2DM). What this study adds: Besides correlated with SII, EFV was further associated with T2DM and high sensitivity in detecting diabetic subjects. How this study might affect research, practice, or policy: The results of the present study may guide clinicians in personalizing preventive strategies, such as, identifying patients at higher cardiometabolic risk who could benefit from intensive lifestyle or pharmacological interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgaf181","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:52:12Z","timestamp":1759492332000},"page":"342-348","source":"Crossref","is-referenced-by-count":10,"title":["Systemic inflammatory markers and epicardial fat volume as predictors of cardiometabolic risk in type 2 diabetes"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-7444","authenticated-orcid":false,"given":"Mehmet","family":"Cosgun","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bolu Abant Izzet Baysal University , Golkoy, 14030, Bolu 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