{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:46:37Z","timestamp":1782290797241,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1209","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hebei Province national college students innovation and entrepreneurship training project"},{"name":"Hebei North University Campus level Cultivation and Research Project","award":["XJPY2024029"],"award-info":[{"award-number":["XJPY2024029"]}]},{"name":"Graduate Innovation Funding Project in Hebei Province","award":["CXZZSS2025118"],"award-info":[{"award-number":["CXZZSS2025118"]}]},{"name":"Postgraduate Education Project of Hebei North College","award":["CX202409"],"award-info":[{"award-number":["CX202409"]}]},{"name":"Hebei Provincial Natural Science Precision Medicine Joint Fund Project","award":["202410092006"],"award-info":[{"award-number":["202410092006"]}]},{"name":"Hebei Provincial Natural Science Precision Medicine Joint Fund Project","award":["H2022405033"],"award-info":[{"award-number":["H2022405033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) screening is crucial for prevention. This study explored serum complement component 1q (C1QC) and vascular cell adhesion molecule-1 (VCAM-1) expression in CRC\/polyp patients and their clinical significance for CRC diagnosis\/staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples from 135 CRC patients, 135 polyp\/adenoma patients, and 135 healthy controls (collected between 1 January 2023 and October 30 2023) were analyzed retrospectively. Data-independent acquisition proteomics identified differentially expressed proteins. C1QC and VCAM-1 levels were quantified via enzyme-linked immunosorbent assay. Diagnostic performance was evaluated via receiver operating characteristic curves and the area under the curve. Statistical analysis (SPSS 27.0, GraphPad Prism 9.5.1) included analysis of variance, Pearson correlation, and logistic regression (P\u2009&amp;lt;\u2009.05 was considered significant).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>C1QC and VCAM-1 levels were significantly greater in the CRC patient group than in the healthy\/polyp group (P\u2009&amp;lt;\u2009.05), with no difference between the polyp and healthy groups (P\u2009&amp;gt;\u2009.05). Receiver operating characteristic analysis revealed that C1QC (cutoff: 52.34\u00a0\u03bcg\/dl) and VCAM-1 (cutoff: 431.215\u00a0ng\/ml) had 78.2% and 66.8% diagnostic accuracy, respectively. Combined detection achieved 80.2% accuracy, surpassing that of carcinoembryonic antigen\/carbohydrate antigen 199. Both biomarkers increased with disease progression (P\u2009&amp;lt;\u2009.05) and aided staging assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum C1QC and VCAM-1 demonstrate high diagnostic efficacy in CRC, correlate with pathological features, and hold promise as novel serological screening biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgaf237","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:47:38Z","timestamp":1766234858000},"page":"633-644","source":"Crossref","is-referenced-by-count":0,"title":["Levels and clinical significance of serum C1QC and VCAM-1 in patients with colorectal cancer or colorectal polyps\/adenomas"],"prefix":"10.1093","volume":"102","author":[{"given":"Chunbaixue","family":"Yang","sequence":"first","affiliation":[{"name":"Graduate College, Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bizhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The First Affiliated Hospital of Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, The First Affiliated Hospital of Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei Province,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Oncology, The First Affiliated Hospital of Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei Province ,","place":["China"]},{"name":"Department of General Surgery, The First Affiliated Hospital of Hebei North University , 11 Diamond South Road, Zhangjiakou 075000, Hebei 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