{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:54:10Z","timestamp":1789134850939,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1209","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prediabetes affects nearly one-third of adults in the United States and is increasingly recognized as a contributor to early chronic kidney disease (CKD). This review summarizes current evidence linking prediabetes with early kidney changes, including albuminuria, glomerular hyperfiltration, and mild renal impairment, as well as its association with increased cardiovascular risk. Large observational cohorts, such as the Chronic Renal Insufficiency Cohort, suggest an association between prediabetes and progression of proteinuria, although its independent contribution to advanced CKD remains variable. We review proposed mechanisms, including insulin resistance, low-grade hyperglycemia, altered tubulo-glomerular feedback mediated by sodium\u2013glucose cotransporter 2 activity, inflammation, and endothelial dysfunction. Variability in diagnostic thresholds across major guidelines complicates risk stratification. Emerging biomarkers may facilitate earlier detection but require further validation. Early identification and guideline-directed lifestyle and pharmacological interventions may help mitigate CKD progression and related cardiovascular outcomes. These insights inform population-level screening, prevention, and decision-making.<\/jats:p>","DOI":"10.1093\/postmj\/qgag009","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:28:32Z","timestamp":1768307312000},"page":"588-597","source":"Crossref","is-referenced-by-count":1,"title":["Prediabetes and chronic kidney disease: a comprehensive review of association and clinical implications"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-6751","authenticated-orcid":false,"given":"Boney","family":"Lapsiwala","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical City Arlington , 3301 Matlock Rd, Arlington, TX, 76015 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratiksha Shankarlal","family":"Nathani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Barnabas Hospital , 4422 Third Ave, Bronx, NY, 10457 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Bhalodia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamilton Medical Center , 1200 Memorial Dr, Dalton, GA, 30720 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anvitha","family":"Rangan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Landmark Medical Center\/New York Medical College , 115 Cass Ave, Woonsocket, RI-02895 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Rajpopat","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Lehigh Valley Health Network , 1250 S Cedar Crest Blvd, Allentown, PA, 18103 ,","place":["United 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University of Alabama at Birmingham , 1802 6th Ave S, Birmingham, AL, 35233 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopa","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geisinger Wyoming Valley Medical Center , 1000E Mountain Blvd, Wilkes-Barre, PA, 18711 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Bali","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Geisinger Wyoming Valley Medical Center , 1000E Mountain Blvd, Wilkes-Barre, PA, 18711 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeranna","family":"Vibhuti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical City Arlington , 3301 Matlock Rd, Arlington, TX, 76015 ,","place":["United 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