{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:25:25Z","timestamp":1787307925972,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1211","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diabetic kidney disease (DKD), a chronic microvascular complication is leading cause of End Stage Kidney disease (ESKD). Reduction of \u226530% urinary albumin is recommended to slow ESKD progression. Remote Ischemic conditioning (RIC) induces brief episodes of ischemia and reperfusion and has protective effect on various organs. The current study aims to explore the effects of RIC on albuminuria reduction in adults with type-2 Diabetes Mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this double blind, sham controlled, Randomized Clinical Trial, we assigned 40 normotensive Diabetic adults with moderate and severely increased albuminuria to RIC group (n\u2009=\u200920) or Sham group (n\u2009=\u200920) weekly for 8\u00a0weeks. Primary outcome was reduction in albuminuria at the end of 8\u00a0weeks. Secondary outcomes were changes in serum creatinine, e-Glomerular Filtration Rate (eGFR), and HbA1c levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The reduction in albuminuria at the end of 8\u00a0weeks was 37.9% [Median (IQR): \u22127.5, 43.9] in the RIC group while it increased by 1.10% (\u22125.6, 15.2) in the Sham group (P\u2009=\u20090.015). Significant reduction was noted in serum creatinine in RIC group from 1 to 0.83\u00a0mg\/dl as compared to increase in Sham group from 0.97 to 1.1\u00a0mg\/dl (P\u2009=\u20090.0004). The mean eGFR in the RIC group improved from 85 to 99 (ml\/min\/1.73m2) P\u2009=\u20090.0001). No significant change was detected in HbA1C levels. Mild pain was the only adverse effect noted in 10% in the RIC group and none in the Sham group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among adults with DKD, treatment with RIC significantly reduced albuminuria and serum creatinine while improving the eGFR (CTRI\/2024\/09\/074453).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/postmj\/qgag040","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T12:41:22Z","timestamp":1773492082000},"page":"840-846","source":"Crossref","is-referenced-by-count":0,"title":["Effect of remote ischemic conditioning on albuminuria in adults with diabetes mellitus (ricadime): a parallel group, double blind, sham controlled, randomized clinical trial"],"prefix":"10.1093","volume":"102","author":[{"given":"Nishanth","family":"Dev","sequence":"first","affiliation":[{"name":"Department of Medicine, VMMC & Safdarjung Hospital , Ansari Nagar, Delhi 110029 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7743-1760","authenticated-orcid":false,"given":"Garima","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, VMMC & Safdarjung Hospital , Ansari Nagar, Delhi 110029 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, VMMC & Safdarjung Hospital , Ansari Nagar, Delhi 110029 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-6550","authenticated-orcid":false,"given":"Jhuma","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, AlIMS , Ansari Nagar, Delhi 110029 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"2026082105412303200_ref1","volume-title":"International Diabetes Federation Diabetes Atlas","year":"2021","edition":"10th"},{"key":"2026082105412303200_ref2","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1002\/(SICI)1096-9136(199712)14:5+&lt;S7::AID-DIA522&gt;3.0.CO;2-R","article-title":"The rising global burden of diabetes and its complications: Estimates and projections to the year 2010","volume":"14","author":"Amos","year":"1997","journal-title":"Diabet Med"},{"key":"2026082105412303200_ref3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2337\/diacare.19.4.305","article-title":"Excess mortality and its relation to hypertension and proteinuria in diabetic patients. 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